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    HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

    Gene ID: 10075, updated on 7-Apr-2024

    Summary

    Official Symbol
    HUWE1provided by HGNC
    Official Full Name
    HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1provided by HGNC
    Primary source
    HGNC:HGNC:30892
    See related
    Ensembl:ENSG00000086758 MIM:300697; AllianceGenome:HGNC:30892
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MULE; Ib772; LASU1; MRXST; UREB1; HECTH9; URE-B1; ARF-BP1; HSPC272
    Summary
    This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]
    Expression
    Ubiquitous expression in ovary (RPKM 14.5), testis (RPKM 13.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    Xp11.22
    Exon count:
    87
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (53532096..53686719, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (52818443..52973077, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (53559057..53713664, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene vault RNA 3-1, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13191 Neighboring gene TIPIN pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:53588722-53589921 Neighboring gene microRNA let-7f-2 Neighboring gene microRNA 98 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:53619238-53620437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20859 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:53713671-53713845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29664 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:53739227-53739726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29666 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:53742749-53743948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29667 Neighboring gene MRPL32 pseudogene 2 Neighboring gene MRPS18C pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Intellectual disability, X-linked syndromic, Turner type
    MedGen: C2678046 OMIM: 309590 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2018-09-26)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2018-09-26)

    ClinGen Genome Curation Page

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Gag-Pol gag-pol Co-immunoprecipitation shows interaction of HIV-1 Gag-Pol with Huwe1 through IN domain (residues 1148-1435) PubMed
    Rev rev HIV-1 Rev interacting protein, HECT, UBA and WWE domain containing 1 (HUWE1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    Vif vif HIV-1 Vif is identified to have a physical interaction with HECT, UBA and WWE domain containing 1 (HUWE1) in human HEK293 and/or Jurkat cell lines PubMed
    integrase gag-pol Co-immunoprecipitation shows interaction of HIV-1 IN with Huwe1 through the CCD domain of IN PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1) at amino acid residues 3686-3687 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0312

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA binding HDA PubMed 
    enables histone ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in base-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitophagy in response to mitochondrial depolarization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein targeting to mitochondrion HMP PubMed 
    involved_in positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase HUWE1
    Names
    ARF-binding protein 1
    BJ-HCC-24 tumor antigen
    HECT domain protein LASU1
    HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
    HECT-type E3 ubiquitin transferase HUWE1
    Mcl-1 ubiquitin ligase E3
    URE-binding protein 1
    homologous to E6AP carboxyl terminus homologous protein 9
    large structure of UREB1
    upstream regulatory element-binding protein 1
    NP_113584.3
    XP_005262022.1
    XP_011529049.1
    XP_011529053.1
    XP_016884687.1
    XP_016884688.1
    XP_016884691.1
    XP_016884692.1
    XP_047297667.1
    XP_047297668.1
    XP_047297669.1
    XP_047297670.1
    XP_047297671.1
    XP_047297672.1
    XP_047297673.1
    XP_047297674.1
    XP_047297675.1
    XP_047297676.1
    XP_047297677.1
    XP_047297678.1
    XP_047297679.1
    XP_047297680.1
    XP_047297681.1
    XP_047297682.1
    XP_047297683.1
    XP_047297684.1
    XP_047297685.1
    XP_047297686.1
    XP_047297687.1
    XP_047297688.1
    XP_047297689.1
    XP_047297690.1
    XP_047297691.1
    XP_047297692.1
    XP_047297693.1
    XP_047297694.1
    XP_047297695.1
    XP_047297696.1
    XP_047297697.1
    XP_047297698.1
    XP_047297699.1
    XP_047297700.1
    XP_047297701.1
    XP_047297702.1
    XP_047297703.1
    XP_047297704.1
    XP_047297705.1
    XP_047297706.1
    XP_047297707.1
    XP_047297708.1
    XP_054182256.1
    XP_054182257.1
    XP_054182258.1
    XP_054182259.1
    XP_054182260.1
    XP_054182261.1
    XP_054182262.1
    XP_054182263.1
    XP_054182264.1
    XP_054182265.1
    XP_054182266.1
    XP_054182267.1
    XP_054182268.1
    XP_054182269.1
    XP_054182270.1
    XP_054182271.1
    XP_054182272.1
    XP_054182273.1
    XP_054182274.1
    XP_054182275.1
    XP_054182276.1
    XP_054182277.1
    XP_054182278.1
    XP_054182279.1
    XP_054182280.1
    XP_054182281.1
    XP_054182282.1
    XP_054182283.1
    XP_054182284.1
    XP_054182285.1
    XP_054182286.1
    XP_054182287.1
    XP_054182288.1
    XP_054182289.1
    XP_054182290.1
    XP_054182291.1
    XP_054182292.1
    XP_054182293.1
    XP_054182294.1
    XP_054182295.1
    XP_054182296.1
    XP_054182297.1
    XP_054182298.1
    XP_054182299.1
    XP_054182300.1
    XP_054182301.1
    XP_054182302.1
    XP_054182303.1
    XP_054182304.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016261.2 RefSeqGene

      Range
      5015..159638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_031407.7NP_113584.3  E3 ubiquitin-protein ligase HUWE1

      See identical proteins and their annotated locations for NP_113584.3

      Status: REVIEWED

      Source sequence(s)
      AB002310, AC231658, AY772009, BX323845, DQ097177, R60532
      Consensus CDS
      CCDS35301.1
      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
      UniProtKB/TrEMBL
      A0A994J483
      Related
      ENSP00000262854.6, ENST00000262854.11
      Conserved Domains (7) summary
      smart00119
      Location:40434371
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:40194372
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:13171356
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:16171678
      WWE; WWE domain
      pfam06012
      Location:92367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430814
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:29683077
      DUF4414; Domain of unknown function (DUF4414)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      53532096..53686719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441744.1XP_047297700.1  E3 ubiquitin-protein ligase HUWE1 isoform X20

    2. XM_047441734.1XP_047297690.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

    3. XM_047441751.1XP_047297707.1  E3 ubiquitin-protein ligase HUWE1 isoform X25

    4. XM_047441741.1XP_047297697.1  E3 ubiquitin-protein ligase HUWE1 isoform X19

    5. XM_011530747.2XP_011529049.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      See identical proteins and their annotated locations for XP_011529049.1

      UniProtKB/TrEMBL
      A0A994J483
      Conserved Domains (7) summary
      cd00078
      Location:41024455
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:14001439
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:17001761
      WWE; WWE domain
      pfam06012
      Location:92367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430897
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:30513160
      DUF4414; Domain of unknown function (DUF4414)
      cl26464
      Location:28183149
      Atrophin-1; Atrophin-1 family
    6. XM_047441739.1XP_047297695.1  E3 ubiquitin-protein ligase HUWE1 isoform X18

    7. XM_047441729.1XP_047297685.1  E3 ubiquitin-protein ligase HUWE1 isoform X15

    8. XM_017029199.2XP_016884688.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A994J483
    9. XM_047441736.1XP_047297692.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

    10. XM_047441742.1XP_047297698.1  E3 ubiquitin-protein ligase HUWE1 isoform X19

    11. XM_047441732.1XP_047297688.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
    12. XM_047441713.1XP_047297669.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

    13. XM_047441730.1XP_047297686.1  E3 ubiquitin-protein ligase HUWE1 isoform X15

    14. XM_017029202.2XP_016884691.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A994J483
    15. XM_047441752.1XP_047297708.1  E3 ubiquitin-protein ligase HUWE1 isoform X26

    16. XM_047441743.1XP_047297699.1  E3 ubiquitin-protein ligase HUWE1 isoform X20

      Related
      ENSP00000515693.1, ENST00000704099.1
    17. XM_047441735.1XP_047297691.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

    18. XM_047441750.1XP_047297706.1  E3 ubiquitin-protein ligase HUWE1 isoform X25

    19. XM_047441740.1XP_047297696.1  E3 ubiquitin-protein ligase HUWE1 isoform X19

    20. XM_005261965.5XP_005262022.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      See identical proteins and their annotated locations for XP_005262022.1

      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
      UniProtKB/TrEMBL
      A0A994J483
      Related
      ENSP00000340648.3, ENST00000342160.7
      Conserved Domains (7) summary
      smart00119
      Location:40434371
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:40194372
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:13171356
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:16171678
      WWE; WWE domain
      pfam06012
      Location:92367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430814
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:29683077
      DUF4414; Domain of unknown function (DUF4414)
    21. XM_047441714.1XP_047297670.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

    22. XM_047441738.1XP_047297694.1  E3 ubiquitin-protein ligase HUWE1 isoform X18

    23. XM_047441728.1XP_047297684.1  E3 ubiquitin-protein ligase HUWE1 isoform X15

    24. XM_047441747.1XP_047297703.1  E3 ubiquitin-protein ligase HUWE1 isoform X22

    25. XM_047441727.1XP_047297683.1  E3 ubiquitin-protein ligase HUWE1 isoform X14

    26. XM_047441724.1XP_047297680.1  E3 ubiquitin-protein ligase HUWE1 isoform X11

    27. XM_047441722.1XP_047297678.1  E3 ubiquitin-protein ligase HUWE1 isoform X9

    28. XM_047441720.1XP_047297676.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

    29. XM_047441718.1XP_047297674.1  E3 ubiquitin-protein ligase HUWE1 isoform X5

    30. XM_047441712.1XP_047297668.1  E3 ubiquitin-protein ligase HUWE1 isoform X2

    31. XM_047441749.1XP_047297705.1  E3 ubiquitin-protein ligase HUWE1 isoform X24

    32. XM_047441748.1XP_047297704.1  E3 ubiquitin-protein ligase HUWE1 isoform X23

    33. XM_047441746.1XP_047297702.1  E3 ubiquitin-protein ligase HUWE1 isoform X21

    34. XM_047441726.1XP_047297682.1  E3 ubiquitin-protein ligase HUWE1 isoform X13

    35. XM_047441725.1XP_047297681.1  E3 ubiquitin-protein ligase HUWE1 isoform X12

    36. XM_047441723.1XP_047297679.1  E3 ubiquitin-protein ligase HUWE1 isoform X10

    37. XM_047441721.1XP_047297677.1  E3 ubiquitin-protein ligase HUWE1 isoform X8

    38. XM_047441719.1XP_047297675.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    39. XM_047441717.1XP_047297673.1  E3 ubiquitin-protein ligase HUWE1 isoform X4

    40. XM_017029198.3XP_016884687.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A994J483
    41. XM_047441745.1XP_047297701.1  E3 ubiquitin-protein ligase HUWE1 isoform X20

    42. XM_047441737.1XP_047297693.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

    43. XM_047441731.1XP_047297687.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
      Related
      ENSP00000479451.1, ENST00000612484.4
    44. XM_011530751.3XP_011529053.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      See identical proteins and their annotated locations for XP_011529053.1

      UniProtKB/TrEMBL
      A0A994J483
      Conserved Domains (7) summary
      cd00078
      Location:41024455
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:14001439
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:17001761
      WWE; WWE domain
      pfam06012
      Location:92367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430897
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:30513160
      DUF4414; Domain of unknown function (DUF4414)
      cl26464
      Location:28183149
      Atrophin-1; Atrophin-1 family
    45. XM_017029203.2XP_016884692.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      A0A994J483
    46. XM_047441733.1XP_047297689.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
    47. XM_047441715.1XP_047297671.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

    48. XM_047441711.1XP_047297667.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    49. XM_047441716.1XP_047297672.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      52818443..52973077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326321.1XP_054182296.1  E3 ubiquitin-protein ligase HUWE1 isoform X20

    2. XM_054326310.1XP_054182285.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

    3. XM_054326328.1XP_054182303.1  E3 ubiquitin-protein ligase HUWE1 isoform X25

    4. XM_054326318.1XP_054182293.1  E3 ubiquitin-protein ligase HUWE1 isoform X19

    5. XM_054326287.1XP_054182262.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

    6. XM_054326316.1XP_054182291.1  E3 ubiquitin-protein ligase HUWE1 isoform X18

    7. XM_054326304.1XP_054182279.1  E3 ubiquitin-protein ligase HUWE1 isoform X15

    8. XM_054326281.1XP_054182256.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    9. XM_054326312.1XP_054182287.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

    10. XM_054326319.1XP_054182294.1  E3 ubiquitin-protein ligase HUWE1 isoform X19

    11. XM_054326307.1XP_054182282.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
    12. XM_054326288.1XP_054182263.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

    13. XM_054326305.1XP_054182280.1  E3 ubiquitin-protein ligase HUWE1 isoform X15

    14. XM_054326282.1XP_054182257.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    15. XM_054326309.1XP_054182284.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
    16. XM_054326291.1XP_054182266.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

    17. XM_054326285.1XP_054182260.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    18. XM_054326329.1XP_054182304.1  E3 ubiquitin-protein ligase HUWE1 isoform X26

    19. XM_054326320.1XP_054182295.1  E3 ubiquitin-protein ligase HUWE1 isoform X20

    20. XM_054326311.1XP_054182286.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

    21. XM_054326327.1XP_054182302.1  E3 ubiquitin-protein ligase HUWE1 isoform X25

    22. XM_054326317.1XP_054182292.1  E3 ubiquitin-protein ligase HUWE1 isoform X19

    23. XM_054326315.1XP_054182290.1  E3 ubiquitin-protein ligase HUWE1 isoform X18

    24. XM_054326303.1XP_054182278.1  E3 ubiquitin-protein ligase HUWE1 isoform X15

    25. XM_054326324.1XP_054182299.1  E3 ubiquitin-protein ligase HUWE1 isoform X22

    26. XM_054326302.1XP_054182277.1  E3 ubiquitin-protein ligase HUWE1 isoform X14

    27. XM_054326299.1XP_054182274.1  E3 ubiquitin-protein ligase HUWE1 isoform X11

    28. XM_054326297.1XP_054182272.1  E3 ubiquitin-protein ligase HUWE1 isoform X9

    29. XM_054326295.1XP_054182270.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

    30. XM_054326293.1XP_054182268.1  E3 ubiquitin-protein ligase HUWE1 isoform X5

    31. XM_054326286.1XP_054182261.1  E3 ubiquitin-protein ligase HUWE1 isoform X2

    32. XM_054326326.1XP_054182301.1  E3 ubiquitin-protein ligase HUWE1 isoform X24

    33. XM_054326325.1XP_054182300.1  E3 ubiquitin-protein ligase HUWE1 isoform X23

    34. XM_054326323.1XP_054182298.1  E3 ubiquitin-protein ligase HUWE1 isoform X21

    35. XM_054326301.1XP_054182276.1  E3 ubiquitin-protein ligase HUWE1 isoform X13

    36. XM_054326300.1XP_054182275.1  E3 ubiquitin-protein ligase HUWE1 isoform X12

    37. XM_054326298.1XP_054182273.1  E3 ubiquitin-protein ligase HUWE1 isoform X10

    38. XM_054326296.1XP_054182271.1  E3 ubiquitin-protein ligase HUWE1 isoform X8

    39. XM_054326294.1XP_054182269.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    40. XM_054326292.1XP_054182267.1  E3 ubiquitin-protein ligase HUWE1 isoform X4

    41. XM_054326322.1XP_054182297.1  E3 ubiquitin-protein ligase HUWE1 isoform X20

    42. XM_054326314.1XP_054182289.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

    43. XM_054326306.1XP_054182281.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
    44. XM_054326289.1XP_054182264.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

    45. XM_054326308.1XP_054182283.1  E3 ubiquitin-protein ligase HUWE1 isoform X16

      UniProtKB/Swiss-Prot
      O15029, Q4G2Z2, Q5H961, Q6P4D0, Q7Z6Z7, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9
    46. XM_054326284.1XP_054182259.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    47. XM_054326283.1XP_054182258.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    48. XM_054326313.1XP_054182288.1  E3 ubiquitin-protein ligase HUWE1 isoform X17

    49. XM_054326290.1XP_054182265.1  E3 ubiquitin-protein ligase HUWE1 isoform X3