U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from MedGen

    • Showing Current items.

    FZD2 frizzled class receptor 2 [ Homo sapiens (human) ]

    Gene ID: 2535, updated on 2-May-2024

    Summary

    Official Symbol
    FZD2provided by HGNC
    Official Full Name
    frizzled class receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:4040
    See related
    Ensembl:ENSG00000180340 MIM:600667; AllianceGenome:HGNC:4040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Fz2; fz-2; fzE2; hFz2; OMOD2
    Summary
    This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FZD2 in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (44557484..44561262)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (45411390..45415168)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (42634852..42638630)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene G-patch domain containing 8 Neighboring gene RNA, 7SL, cytoplasmic 258, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:42498551-42499524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8593 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:42588763-42589328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8594 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8595 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:42610782-42611286 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:42611287-42611790 Neighboring gene uncharacterized LOC105371791 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:42617132-42618126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:42625431-42625978 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:42633347-42634116 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:42634117-42634884 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:42635102-42636062 Neighboring gene MPRA-validated peak2866 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:42664661-42665226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:42675147-42675724 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:42684805-42685416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8599 Neighboring gene long intergenic non-protein coding RNA 1180 Neighboring gene single-pass membrane protein with coiled-coil domains 4 pseudogene 1 Neighboring gene meiosis specific with coiled-coil domain

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Wnt receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Wnt receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt-protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Wnt signaling pathway, planar cell polarity pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cochlea morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hard palate development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inner ear receptor cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membranous septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscular septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in outflow tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in planar cell polarity pathway involved in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in clathrin-coated endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    frizzled-2
    Names
    frizzled 2, seven transmembrane spanning receptor
    frizzled family receptor 2
    frizzled homolog 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001466.4NP_001457.1  frizzled-2 precursor

      See identical proteins and their annotated locations for NP_001457.1

      Status: REVIEWED

      Source sequence(s)
      AC103703, AI376463, AW023425, BC052266
      Consensus CDS
      CCDS11484.1
      UniProtKB/Swiss-Prot
      Q0VG82, Q14332
      UniProtKB/TrEMBL
      Q86UZ8
      Related
      ENSP00000323901.3, ENST00000315323.5
      Conserved Domains (2) summary
      cd07464
      Location:35161
      CRD_FZ2; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 2 (Fz2) receptor
      cd15245
      Location:234563
      7tmF_FZD2; class F frizzled subfamily 2, member of 7-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      44557484..44561262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      45411390..45415168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)