U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from MedGen

    • Showing Current items.

    MMP9 matrix metallopeptidase 9 [ Homo sapiens (human) ]

    Gene ID: 4318, updated on 7-Apr-2024

    Summary

    Official Symbol
    MMP9provided by HGNC
    Official Full Name
    matrix metallopeptidase 9provided by HGNC
    Primary source
    HGNC:HGNC:7176
    See related
    Ensembl:ENSG00000100985 MIM:120361; AllianceGenome:HGNC:7176
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GELB; CLG4B; MMP-9; MANDP2
    Summary
    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in bone marrow (RPKM 144.9), lymph node (RPKM 49.8) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MMP9 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (46008908..46016561)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (47744921..47752589)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44637547..44645200)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44603922-44604458 Neighboring gene ferritin light chain pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44624055-44624562 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44632651-44633302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:44633303-44633954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44640983-44641493 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12969 Neighboring gene SLC12A5 and MMP9 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12970 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12971 Neighboring gene solute carrier family 12 member 5 Neighboring gene Sharpr-MPRA regulatory region 13245 Neighboring gene Sharpr-MPRA regulatory region 3425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17957 Neighboring gene nuclear receptor coactivator 5 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:44717073-44717887 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:44717888-44718701

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Metaphyseal anadysplasia 2
    MedGen: C2751322 OMIM: 613073 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection significantly decreases MMP9 in blood plasma clinical samples PubMed
    HIV-1 infection in macrophages decreases interactions between Cathepsin B and MMP9 PubMed
    Knockdown of matrix metallopeptidase 9 (gelatinase B; 92kDa gelatinase; 92kDa type IV collagenase; MMP9) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 JRFL Env (gp120) upregulates MMP9 in ARPE-19 and primary human RPE cells and is dependent upon DC-SIGN PubMed
    env HIV-1 gp120-mediated binding of human mannose receptor induces MMP-9 expression in vaginal epithelial cells PubMed
    env Inhibition of NRF2 by siRNA results in increased NOX2, NFkappaB (p65/p50), TNF-alpha, and MMP-9 proteins in astrocytes exposed to HIV-1 gp120 PubMed
    env Matrix metalloproteinases MMP2 and MMP9 participate in the maturation process of cleavage and activation of IL-1beta based on the intracerebroventricular injection of the HIV-1 envelope glycoprotein gp120 PubMed
    env Concomitant incubation with gp120 and methamphetamine stimulates LPS-induced MMP-9 expression and biological activity in monocyte-derived macrophages PubMed
    env T- and M-tropic HIV-1 gp120 proteins are able to induce the secretion of matrix metalloproteinase 9 (MMP-9) by T cells or glioma cells; MMP-9 is an extracellular metalloproteinase present in cerebrospinal fluid of patients with HIV-1 PubMed
    Nef nef Overexpression of HIV-1 Nef and ALK effect gelatinase activation in astrocytic glioma cells PubMed
    nef MMP-9 activity in the cerebrospinal fluid (CSF) samples from rats is induced by injecting the rats intracisternally with recombinant HIV-1 Nef protein, but not after injection of heat-treated Nef, HIV-1 gp120, HIV-1 gp160 or PBS PubMed
    Tat tat The basic domain (49RKKRRQRRR57) of HIV-1 Tat is essential for enhancing the FGF-induced activation of ERK, Rho-A, and MLC2 and upregulates the expression of MMP-9 in human podocytes PubMed
    tat HIV-1 Tat protein increases the permeability of primary human brain micro vascular endothelial cells by both inhibiting occludin expression and cleaving occludin via matrix metalloproteinase-9 PubMed
    tat HIV-1 Tat-induced MAPK (ERK, JNK, and p38) activation is required for MMP-9 expression in human astrocytes PubMed
    tat HIV-1 Tat-mediated upregulation of MMP-9 in human astrocytes results from NF-kappaB activation pathway PubMed
    tat HIV-1 Tat upregulates the expression of MMP-9 in monocytes in an IL-1beta, TNF-alpha, and tyrosine phosphatase dependent manner PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables collagen binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables endopeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metalloendopeptidase activity TAS
    Traceable Author Statement
    more info
     
    enables metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables serine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
     
    enables zinc ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to UV-A IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to cadmium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to reactive oxygen species IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in collagen catabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in embryo implantation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endodermal cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in extracellular matrix disassembly TAS
    Traceable Author Statement
    more info
     
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in macrophage differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cation channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epithelial cell differentiation involved in kidney development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of keratinocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of neuroinflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to amyloid-beta ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in skeletal system development IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    matrix metalloproteinase-9
    Names
    macrophage gelatinase
    matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
    matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
    type V collagenase
    NP_004985.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011468.1 RefSeqGene

      Range
      5001..12654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004994.3NP_004985.2  matrix metalloproteinase-9 preproprotein

      See identical proteins and their annotated locations for NP_004985.2

      Status: REVIEWED

      Source sequence(s)
      AW468235, BC006093, CN288579, J05070
      Consensus CDS
      CCDS13390.1
      UniProtKB/Swiss-Prot
      B2R7V9, P14780, Q3LR70, Q8N725, Q9H4Z1, Q9UCJ9, Q9UCL1, Q9UDK2
      UniProtKB/TrEMBL
      B7Z507
      Related
      ENSP00000361405.3, ENST00000372330.3
      Conserved Domains (6) summary
      smart00059
      Location:281329
      FN2; Fibronectin type 2 domain
      cd00094
      Location:514704
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:115444
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00040
      Location:347388
      fn2; Fibronectin type II domain
      pfam00413
      Location:115444
      Peptidase_M10; Matrixin
      pfam04886
      Location:472506
      PT; PT repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      46008908..46016561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      47744921..47752589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)