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    PLEC plectin [ Homo sapiens (human) ]

    Gene ID: 5339, updated on 1-Mar-2024

    Summary

    Official Symbol
    PLECprovided by HGNC
    Official Full Name
    plectinprovided by HGNC
    Primary source
    HGNC:HGNC:9069
    See related
    Ensembl:ENSG00000178209 MIM:601282; AllianceGenome:HGNC:9069
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HD1; PCN; EBS1; EBSO; PLTN; EBS5A; EBS5B; EBS5C; EBS5D; EBSMD; EBSND; EBSOG; EBSPA; PLEC1; LGMD2Q; PLEC1b; LGMDR17
    Summary
    Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as "hemidesmosomal protein 1" or "plectin 1, intermediate filament binding 500kDa". These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in skin (RPKM 18.0), colon (RPKM 16.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PLEC in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143915153..143976745, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145073432..145135033, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144989321..145050913, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144923032-144923762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144923763-144924492 Neighboring gene nuclear receptor binding protein 2 Neighboring gene microRNA 6845 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144939917-144940418 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:144940419-144940918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144948081-144948772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144949483-144950125 Neighboring gene epiplakin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144953345-144953987 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144959005-144959528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144959529-144960052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144964657-144965548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144965549-144966440 Neighboring gene Sharpr-MPRA regulatory region 5026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144977006-144977576 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:144990280-144990475 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144999476-145000347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28076 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28075 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145002644-145002773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145006382-145007317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28079 Neighboring gene Sharpr-MPRA regulatory region 8265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28080 Neighboring gene uncharacterized LOC124902040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19634 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145020877-145021664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145021665-145022452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145024027-145024814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19637 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19639 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145031501-145032404 Neighboring gene microRNA 661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145038963-145039740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145039741-145040518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145040519-145041295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145046021-145046870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145046871-145047718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19641 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19643 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145050844-145051005 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145051354-145051848 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19646 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28083 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145060401-145061304 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19648 Neighboring gene Sharpr-MPRA regulatory region 3935 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145065969-145066470 Neighboring gene poly(ADP-ribose) polymerase family member 10 Neighboring gene glutamate ionotropic receptor NMDA type subunit associated protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28085 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19651 Neighboring gene spermatogenesis and centriole associated 1 Neighboring gene NANOG hESC enhancer GRCh37_chr8:145092262-145092784

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Autosomal recessive limb-girdle muscular dystrophy type 2Q
    MedGen: C3150989 OMIM: 613723 GeneReviews: Not available
    Compare labs
    Epidermolysis bullosa simplex 5B, with muscular dystrophy
    MedGen: C2931072 OMIM: 226670 GeneReviews: Epidermolysis Bullosa Simplex
    Compare labs
    Epidermolysis bullosa simplex 5C, with pyloric atresia Compare labs
    Epidermolysis bullosa simplex with nail dystrophy
    MedGen: C4225309 OMIM: 616487 GeneReviews: Not available
    Compare labs
    Epidermolysis bullosa simplex, Ogna type Compare labs
    Junctional epidermolysis bullosa with pyloric atresia Compare labs

    EBI GWAS Catalog

    Description
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
    EBI GWAS Catalog
    New gene functions in megakaryopoiesis and platelet formation.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif Variants of HIV-1 Vif have been shown to form perinuclear aggregates and relocalize plectin to these structures PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of plectin (PLEC) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ankyrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ankyrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables dystroglycan binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein self-association IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of muscle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in T cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actomyosin contractile ring assembly actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to extracellular stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to fluid shear stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydrostatic pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of skin barrier IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hemidesmosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hemidesmosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intermediate filament cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intermediate filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratinocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukocyte migration involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleus organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peripheral nervous system myelin maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-containing complex organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of vascular permeability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in respiratory electron transport chain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to food IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sarcomere organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal myofibril assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tight junction organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmission of nerve impulse IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in wound healing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in brush border IEA
    Inferred from Electronic Annotation
    more info
     
    located_in costamere TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
     
    is_active_in hemidesmosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in hemidesmosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with intermediate filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    plectin
    Names
    hemidesmosomal protein 1
    plectin 1, intermediate filament binding protein 500kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012492.1 RefSeqGene

      Range
      5001..66593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000445.5NP_000436.2  plectin isoform 1c

      See identical proteins and their annotated locations for NP_000436.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) contains the 5'-most coding exon (exon 1c) and encodes isoform 1c.
      Source sequence(s)
      AY480044, BP312608
      Consensus CDS
      CCDS43769.1
      UniProtKB/TrEMBL
      E9PMV1
      Related
      ENSP00000388180.2, ENST00000436759.6
      Conserved Domains (10) summary
      smart00250
      Location:31213157
      PLEC; Plectin repeat
      cd00014
      Location:70172
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:645834
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:187285
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40684109
      Plectin; Plectin repeat
      pfam01576
      Location:13702493
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14701481
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17531955
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13791506
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:15051625
      ATP-synt_B; ATP synthase B/B' CF(0)
    2. NM_001410941.1NP_001397870.1  plectin isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC109322
      Consensus CDS
      CCDS94359.1
      UniProtKB/TrEMBL
      H0YDN1
      Related
      ENSP00000433982.2, ENST00000527303.2
    3. NM_201378.4NP_958780.1  plectin isoform 1f

      See identical proteins and their annotated locations for NP_958780.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1f) contains a distinct N-terminus compared to isoform 1c. Plectin isoform 1f has been found to be concentrated in vinculin-positive structures at actin stress fiber ends (PMID: 14559777).
      Source sequence(s)
      AY480045, BP315878
      Consensus CDS
      CCDS43770.1
      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Related
      ENSP00000348702.3, ENST00000356346.7
      Conserved Domains (10) summary
      smart00250
      Location:30803116
      PLEC; Plectin repeat
      cd00014
      Location:29131
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:604793
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:146244
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40274068
      Plectin; Plectin repeat
      pfam01576
      Location:13292452
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14291440
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17121914
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13381465
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14641584
      ATP-synt_B; ATP synthase B/B' CF(0)
    4. NM_201379.3NP_958781.1  plectin isoform 1e

      See identical proteins and their annotated locations for NP_958781.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1e) contains a distinct N-terminus compared to isoform 1c.
      Source sequence(s)
      AY480046
      Consensus CDS
      CCDS43771.1
      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Related
      ENSP00000347044.2, ENST00000354958.6
      Conserved Domains (10) summary
      smart00250
      Location:30723108
      PLEC; Plectin repeat
      cd00014
      Location:21123
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:596785
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:138236
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40194060
      Plectin; Plectin repeat
      pfam01576
      Location:13212444
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14211432
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17041906
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13301457
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14561576
      ATP-synt_B; ATP synthase B/B' CF(0)
    5. NM_201380.4NP_958782.1  plectin isoform 1

      See identical proteins and their annotated locations for NP_958782.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1) contains a distinct N-terminus compared to isoform 1c.
      Source sequence(s)
      AC109322, AY480047
      Consensus CDS
      CCDS43772.1
      UniProtKB/Swiss-Prot
      Q15148, Q15149, Q16640, Q6S376, Q6S377, Q6S378, Q6S379, Q6S380, Q6S381, Q6S382, Q6S383
      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Related
      ENSP00000323856.4, ENST00000322810.8
      Conserved Domains (11) summary
      smart00250
      Location:32313267
      PLEC; Plectin repeat
      cd00014
      Location:180282
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:755944
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:297395
      CH; Calponin homology (CH) domain
      pfam00681
      Location:41784219
      Plectin; Plectin repeat
      pfam01576
      Location:14802603
      Myosin_tail_1; Myosin tail
      pfam03501
      Location:7101
      S10_plectin; Plectin/S10 domain
      cd16269
      Location:15801591
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:18632065
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:14891616
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:16151735
      ATP-synt_B; ATP synthase B/B' CF(0)
    6. NM_201381.3NP_958783.1  plectin isoform 1d

      See identical proteins and their annotated locations for NP_958783.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1d) contains a distinct N-terminus compared to isoform 1c. Plectin isoform 1d has been found associated with Z-disks in skeletal muscle (PMID: 17389230).
      Source sequence(s)
      AC109322, AY480048
      Consensus CDS
      CCDS47936.1
      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Related
      ENSP00000381756.2, ENST00000398774.6
      Conserved Domains (10) summary
      smart00250
      Location:30623098
      PLEC; Plectin repeat
      cd00014
      Location:11113
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:586775
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:128226
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40094050
      Plectin; Plectin repeat
      pfam01576
      Location:13112434
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14111422
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:16941896
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13201447
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14461566
      ATP-synt_B; ATP synthase B/B' CF(0)
    7. NM_201382.4NP_958784.1  plectin isoform 1b

      See identical proteins and their annotated locations for NP_958784.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1b) contains a distinct N-terminus compared to isoform 1c. Plectin isoform 1b has been found to associate exclusively with mitochondria (PMID: 18541706, 14559777).
      Source sequence(s)
      AC109322, AY480049, BP231761
      Consensus CDS
      CCDS43773.1
      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Related
      ENSP00000346602.3, ENST00000354589.7
      Conserved Domains (10) summary
      smart00250
      Location:30943130
      PLEC; Plectin repeat
      cd00014
      Location:43145
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:618807
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:160258
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40414082
      Plectin; Plectin repeat
      pfam01576
      Location:13432466
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14431454
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17261928
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13521479
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14781598
      ATP-synt_B; ATP synthase B/B' CF(0)
    8. NM_201383.3NP_958785.1  plectin isoform 1g

      See identical proteins and their annotated locations for NP_958785.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1g) contains a distinct N-terminus compared to isoform 1c.
      Source sequence(s)
      AC109322, AY480050
      Consensus CDS
      CCDS43774.1
      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Related
      ENSP00000350277.2, ENST00000357649.6
      Conserved Domains (10) summary
      smart00250
      Location:30983134
      PLEC; Plectin repeat
      cd00014
      Location:47149
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:622811
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:164262
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40454086
      Plectin; Plectin repeat
      pfam01576
      Location:13472470
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14471458
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17301932
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13561483
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14821602
      ATP-synt_B; ATP synthase B/B' CF(0)
    9. NM_201384.3NP_958786.1  plectin isoform 1a

      See identical proteins and their annotated locations for NP_958786.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1a) contains a distinct N-terminus compared to isoform 1c. Plectin isoform 1a has been found to associate specifically with hemidesmosome-like structures in keratinocytes (PMID: 12542521).
      Source sequence(s)
      AC109322, AY480051
      Consensus CDS
      CCDS43775.1
      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Related
      ENSP00000344848.3, ENST00000345136.8
      Conserved Domains (10) summary
      smart00250
      Location:30943130
      PLEC; Plectin repeat
      cd00014
      Location:43145
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:618807
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:160258
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40414082
      Plectin; Plectin repeat
      pfam01576
      Location:13432466
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14431454
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17261928
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13521479
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14781598
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      143915153..143976745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421872.1XP_047277828.1  plectin isoform X7

      UniProtKB/TrEMBL
      E9PMV1
      Related
      ENSP00000434583.1, ENST00000527096.5
    2. XM_006716588.4XP_006716651.1  plectin isoform X6

      UniProtKB/TrEMBL
      E9PMV1
      Related
      ENSP00000437303.2, ENST00000528025.6
      Conserved Domains (10) summary
      smart00250
      Location:31263162
      PLEC; Plectin repeat
      cd00014
      Location:70177
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:650839
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:192290
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40734114
      Plectin; Plectin repeat
      pfam01576
      Location:13752498
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14751486
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17581960
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13841511
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:15101630
      ATP-synt_B; ATP synthase B/B' CF(0)
    3. XM_047421890.1XP_047277846.1  plectin isoform X32

    4. XM_047421875.1XP_047277831.1  plectin isoform X14

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    5. XM_047421889.1XP_047277845.1  plectin isoform X31

    6. XM_005250981.4XP_005251038.1  plectin isoform X12

      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Conserved Domains (10) summary
      smart00250
      Location:30853121
      PLEC; Plectin repeat
      cd00014
      Location:29136
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:609798
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:151249
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40324073
      Plectin; Plectin repeat
      pfam01576
      Location:13342457
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14341445
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17171919
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13431470
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14691589
      ATP-synt_B; ATP synthase B/B' CF(0)
    7. XM_047421893.1XP_047277849.1  plectin isoform X35

    8. XM_047421877.1XP_047277833.1  plectin isoform X19

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    9. XM_047421891.1XP_047277847.1  plectin isoform X33

    10. XM_005250982.5XP_005251039.1  plectin isoform X13

      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Conserved Domains (10) summary
      smart00250
      Location:30773113
      PLEC; Plectin repeat
      cd00014
      Location:21128
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:601790
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:143241
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40244065
      Plectin; Plectin repeat
      pfam01576
      Location:13262449
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14261437
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17091911
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13351462
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14611581
      ATP-synt_B; ATP synthase B/B' CF(0)
    11. XM_047421884.1XP_047277840.1  plectin isoform X27

    12. XM_047421870.1XP_047277826.1  plectin isoform X5

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    13. XM_047421882.1XP_047277838.1  plectin isoform X26

    14. XM_005250976.5XP_005251033.1  plectin isoform X4

      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Conserved Domains (11) summary
      smart00250
      Location:32363272
      PLEC; Plectin repeat
      cd00014
      Location:180287
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:760949
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:302400
      CH; Calponin homology (CH) domain
      pfam00681
      Location:41834224
      Plectin; Plectin repeat
      pfam01576
      Location:14852608
      Myosin_tail_1; Myosin tail
      pfam03501
      Location:7101
      S10_plectin; Plectin/S10 domain
      cd16269
      Location:15851596
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:18682070
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:14941621
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:16201740
      ATP-synt_B; ATP synthase B/B' CF(0)
    15. XM_047421895.1XP_047277851.1  plectin isoform X36

    16. XM_047421878.1XP_047277834.1  plectin isoform X20

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    17. XM_047421892.1XP_047277848.1  plectin isoform X34

    18. XM_005250983.3XP_005251040.1  plectin isoform X18

      UniProtKB/TrEMBL
      A0A8I5KUE3, A0A8I5KYZ1
      Related
      ENSP00000510329.1, ENST00000693060.1
      Conserved Domains (10) summary
      smart00250
      Location:30713107
      PLEC; Plectin repeat
      cd00014
      Location:20122
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:595784
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:137235
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40184059
      Plectin; Plectin repeat
      pfam01576
      Location:13202443
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14201431
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17031905
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13291456
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14551575
      ATP-synt_B; ATP synthase B/B' CF(0)
    19. XM_006716589.3XP_006716652.1  plectin isoform X15

      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Conserved Domains (10) summary
      smart00250
      Location:30763112
      PLEC; Plectin repeat
      cd00014
      Location:20127
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:600789
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:142240
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40234064
      Plectin; Plectin repeat
      pfam01576
      Location:13252448
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14251436
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17081910
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13341461
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14601580
      ATP-synt_B; ATP synthase B/B' CF(0)
    20. XM_005250984.6XP_005251041.1  plectin isoform X21

      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Conserved Domains (10) summary
      smart00250
      Location:30673103
      PLEC; Plectin repeat
      cd00014
      Location:11118
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:591780
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:133231
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40144055
      Plectin; Plectin repeat
      pfam01576
      Location:13162439
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14161427
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:16991901
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13251452
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14511571
      ATP-synt_B; ATP synthase B/B' CF(0)
    21. XM_047421888.1XP_047277844.1  plectin isoform X30

    22. XM_047421874.1XP_047277830.1  plectin isoform X11

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    23. XM_005250979.5XP_005251036.1  plectin isoform X8

      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Conserved Domains (10) summary
      smart00250
      Location:30993135
      PLEC; Plectin repeat
      cd00014
      Location:43150
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:623812
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:165263
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40464087
      Plectin; Plectin repeat
      pfam01576
      Location:13482471
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14481459
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17311933
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13571484
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14831603
      ATP-synt_B; ATP synthase B/B' CF(0)
    24. XM_047421881.1XP_047277837.1  plectin isoform X25

    25. XM_047421869.1XP_047277825.1  plectin isoform X3

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    26. XM_047421880.1XP_047277836.1  plectin isoform X24

    27. XM_011517130.3XP_011515432.1  plectin isoform X2

      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Conserved Domains (10) summary
      smart00250
      Location:30993135
      PLEC; Plectin repeat
      cd00014
      Location:47154
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:623812
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:169267
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40464087
      Plectin; Plectin repeat
      pfam01576
      Location:13482471
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14481459
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17311933
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13571484
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14831603
      ATP-synt_B; ATP synthase B/B' CF(0)
    28. XM_011517132.3XP_011515434.1  plectin isoform X23

      Conserved Domains (5) summary
      smart00250
      Location:19762012
      PLEC; Plectin repeat
      cd00014
      Location:47154
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:627816
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:169267
      CH; Calponin homology (CH) domain
      pfam00681
      Location:29232964
      Plectin; Plectin repeat
    29. XM_005250978.4XP_005251035.1  plectin isoform X1

      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Conserved Domains (10) summary
      smart00250
      Location:31033139
      PLEC; Plectin repeat
      cd00014
      Location:47154
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:627816
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:169267
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40504091
      Plectin; Plectin repeat
      pfam01576
      Location:13522475
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14521463
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17351937
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13611488
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14871607
      ATP-synt_B; ATP synthase B/B' CF(0)
    30. XM_047421887.1XP_047277843.1  plectin isoform X29

    31. XM_047421873.1XP_047277829.1  plectin isoform X10

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    32. XM_047421886.1XP_047277842.1  plectin isoform X28

    33. XM_005250980.5XP_005251037.1  plectin isoform X9

      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Conserved Domains (10) summary
      smart00250
      Location:30993135
      PLEC; Plectin repeat
      cd00014
      Location:43150
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:623812
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:165263
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40464087
      Plectin; Plectin repeat
      pfam01576
      Location:13482471
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14481459
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17311933
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13571484
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14831603
      ATP-synt_B; ATP synthase B/B' CF(0)
    34. XM_011517131.3XP_011515433.1  plectin isoform X17

      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Conserved Domains (10) summary
      smart00250
      Location:30713107
      PLEC; Plectin repeat
      cd00014
      Location:20122
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:595784
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:137235
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40184059
      Plectin; Plectin repeat
      pfam01576
      Location:13202443
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14201431
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17031905
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13291456
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14551575
      ATP-synt_B; ATP synthase B/B' CF(0)
    35. XM_006716590.4XP_006716653.1  plectin isoform X16

      UniProtKB/TrEMBL
      A0A8I5KYZ1
      Conserved Domains (10) summary
      smart00250
      Location:30763112
      PLEC; Plectin repeat
      cd00014
      Location:20127
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:600789
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:142240
      CH; Calponin homology (CH) domain
      pfam00681
      Location:40234064
      Plectin; Plectin repeat
      pfam01576
      Location:13252448
      Myosin_tail_1; Myosin tail
      cd16269
      Location:14251436
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:17081910
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13341461
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl21478
      Location:14601580
      ATP-synt_B; ATP synthase B/B' CF(0)
    36. XM_047421879.1XP_047277835.1  plectin isoform X22

      UniProtKB/TrEMBL
      A0A8I5KSD5, A0A8I5KYZ1
      Related
      ENSP00000510788.1, ENST00000687971.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      145073432..145135033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360666.1XP_054216641.1  plectin isoform X7

      UniProtKB/TrEMBL
      E9PMV1
    2. XM_054360665.1XP_054216640.1  plectin isoform X6

      UniProtKB/TrEMBL
      E9PMV1
    3. XM_054360690.1XP_054216665.1  plectin isoform X32

    4. XM_054360673.1XP_054216648.1  plectin isoform X14

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    5. XM_054360689.1XP_054216664.1  plectin isoform X31

    6. XM_054360671.1XP_054216646.1  plectin isoform X12

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    7. XM_054360693.1XP_054216668.1  plectin isoform X35

    8. XM_054360678.1XP_054216653.1  plectin isoform X19

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    9. XM_054360691.1XP_054216666.1  plectin isoform X33

    10. XM_054360672.1XP_054216647.1  plectin isoform X13

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    11. XM_054360685.1XP_054216660.1  plectin isoform X27

    12. XM_054360664.1XP_054216639.1  plectin isoform X5

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    13. XM_054360684.1XP_054216659.1  plectin isoform X26

    14. XM_054360663.1XP_054216638.1  plectin isoform X4

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    15. XM_054360679.1XP_054216654.1  plectin isoform X20

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    16. XM_054360674.1XP_054216649.1  plectin isoform X15

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    17. XM_054360677.1XP_054216652.1  plectin isoform X18

      UniProtKB/TrEMBL
      A0A8I5KUE3, A0A8I5KYZ1
    18. XM_054360694.1XP_054216669.1  plectin isoform X36

    19. XM_054360692.1XP_054216667.1  plectin isoform X34

    20. XM_054360680.1XP_054216655.1  plectin isoform X21

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    21. XM_054360688.1XP_054216663.1  plectin isoform X30

    22. XM_054360670.1XP_054216645.1  plectin isoform X11

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    23. XM_054360667.1XP_054216642.1  plectin isoform X8

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    24. XM_054360683.1XP_054216658.1  plectin isoform X25

    25. XM_054360662.1XP_054216637.1  plectin isoform X3

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    26. XM_054360682.1XP_054216657.1  plectin isoform X24

    27. XM_054360661.1XP_054216636.1  plectin isoform X2

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    28. XM_054360681.1XP_054216656.1  plectin isoform X23

    29. XM_054360660.1XP_054216635.1  plectin isoform X1

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    30. XM_054360687.1XP_054216662.1  plectin isoform X29

    31. XM_054360669.1XP_054216644.1  plectin isoform X10

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    32. XM_054360686.1XP_054216661.1  plectin isoform X28

    33. XM_054360668.1XP_054216643.1  plectin isoform X9

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    34. XM_054360675.1XP_054216650.1  plectin isoform X16

      UniProtKB/TrEMBL
      A0A8I5KYZ1
    35. XM_054360676.1XP_054216651.1  plectin isoform X17

      UniProtKB/TrEMBL
      A0A8I5KYZ1