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    IL10RA interleukin 10 receptor subunit alpha [ Homo sapiens (human) ]

    Gene ID: 3587, updated on 23-Nov-2023

    Summary

    Official Symbol
    IL10RAprovided by HGNC
    Official Full Name
    interleukin 10 receptor subunit alphaprovided by HGNC
    Primary source
    HGNC:HGNC:5964
    See related
    Ensembl:ENSG00000110324 MIM:146933; AllianceGenome:HGNC:5964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1
    Summary
    The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
    Expression
    Broad expression in spleen (RPKM 29.9), bone marrow (RPKM 20.8) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IL10RA in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (117986394..118003037)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (118002773..118019416)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (117857109..117873752)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FXYD6-FXYD2 readthrough Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:117712427-117713626 Neighboring gene FXYD6 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117726457-117726957 Neighboring gene FXYD domain containing ion transport regulator 6 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:117738498-117739697 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:117740007-117740526 Neighboring gene Sharpr-MPRA regulatory region 1172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117778029-117778529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117784655-117785647 Neighboring gene transmembrane serine protease 13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5577 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:117802800-117803339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117803340-117803878 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19102 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:117843533-117843947 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3941 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5580 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117869597-117870098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117881450-117881950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5581 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19207 Neighboring gene small integral membrane protein 35 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117935307-117935808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117947648-117948243 Neighboring gene RNA, 7SL, cytoplasmic 828, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13014 Neighboring gene uncharacterized LOC105369517 Neighboring gene transmembrane serine protease 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Inflammatory bowel disease 28
    MedGen: C2751053 OMIM: 613148 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables interleukin-10 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-10 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables interleukin-10 receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-10 receptor subunit alpha
    Names
    IL-10 receptor subunit alpha
    IL-10R subunit 1
    IL-10R subunit alpha
    IL-10RA
    interleukin 10 receptor, alpha
    interleukin-10 receptor alpha chain
    interleukin-10 receptor subunit 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016275.1 RefSeqGene

      Range
      5001..20093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_151

    mRNA and Protein(s)

    1. NM_001558.4NP_001549.2  interleukin-10 receptor subunit alpha precursor

      See identical proteins and their annotated locations for NP_001549.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the protein-coding transcript.
      Source sequence(s)
      AK291645, AP002962, BC028082, CA307153
      Consensus CDS
      CCDS8388.1
      UniProtKB/Swiss-Prot
      A8K6I0, B0YJ27, Q13651
      UniProtKB/TrEMBL
      H2DF05
      Related
      ENSP00000227752.4, ENST00000227752.8
      Conserved Domains (2) summary
      pfam01108
      Location:21111
      Tissue_fac; Tissue factor
      cl21522
      Location:129227
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RNA

    1. NR_026691.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate exon compared to variant 1. It is not thought to be protein-coding.
      Source sequence(s)
      AK291645, AK301484, AP002962, BC028082, CA307153

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      117986394..118003037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426882.1XP_047282838.1  interleukin-10 receptor subunit alpha isoform X1

      UniProtKB/TrEMBL
      B7ZAM7
    2. XM_047426884.1XP_047282840.1  interleukin-10 receptor subunit alpha isoform X3

      UniProtKB/TrEMBL
      B4DVW4
    3. XM_047426883.1XP_047282839.1  interleukin-10 receptor subunit alpha isoform X2

      UniProtKB/TrEMBL
      B4DVW4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      118002773..118019416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368667.1XP_054224642.1  interleukin-10 receptor subunit alpha isoform X1

      UniProtKB/TrEMBL
      B4DWD6, B7ZA31, B7ZAM7
    2. XM_054368669.1XP_054224644.1  interleukin-10 receptor subunit alpha isoform X3

      UniProtKB/TrEMBL
      B4DVW4
    3. XM_054368668.1XP_054224643.1  interleukin-10 receptor subunit alpha isoform X2

      UniProtKB/TrEMBL
      B4DVW4