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    KCNJ5 potassium inwardly rectifying channel subfamily J member 5 [ Homo sapiens (human) ]

    Gene ID: 3762, updated on 3-Apr-2024

    Summary

    Official Symbol
    KCNJ5provided by HGNC
    Official Full Name
    potassium inwardly rectifying channel subfamily J member 5provided by HGNC
    Primary source
    HGNC:HGNC:6266
    See related
    Ensembl:ENSG00000120457 MIM:600734; AllianceGenome:HGNC:6266
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CIR; GIRK4; KATP1; LQT13; KIR3.4
    Summary
    This gene encodes an integral membrane protein which belongs to one of seven subfamilies of inward-rectifier potassium channel proteins called potassium channel subfamily J. The encoded protein is a subunit of the potassium channel which is homotetrameric. It is controlled by G-proteins and has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Naturally occurring mutations in this gene are associated with aldosterone-producing adenomas. [provided by RefSeq, Aug 2017]
    Expression
    Biased expression in adrenal (RPKM 34.9), spleen (RPKM 8.6) and 4 other tissues See more
    Orthologs
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    Genomic context

    See KCNJ5 in Genome Data Viewer
    Location:
    11q24.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (128891356..128921163)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (128926287..128956088)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (128761251..128791058)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4058 Neighboring gene CRISPRi-FlowFISH-validated ETS1 regulatory element GRCh37_chr11:128563455-128564187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4062 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:128570339-128571538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4063 Neighboring gene NANOG hESC enhancer GRCh37_chr11:128585502-128586027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5733 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:128587835-128588354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5738 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5737 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128596161-128596660 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:128603944-128604489 Neighboring gene smooth muscle and endothelial cell enriched migration/differentiation-associated lncRNA Neighboring gene Fli-1 proto-oncogene, ETS transcription factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128627636-128628136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128628137-128628637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128646623-128647228 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:128654003-128654550 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:128654551-128655097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5741 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:128689257-128689763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5743 Neighboring gene uncharacterized LOC107984409 Neighboring gene Sharpr-MPRA regulatory region 11395 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:128740730-128741492 Neighboring gene NANOG hESC enhancer GRCh37_chr11:128741942-128742537 Neighboring gene potassium inwardly rectifying channel subfamily J member 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:128771525-128772283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4065 Neighboring gene KCNJ5 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:128796283-128797283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128808070-128808570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128808571-128809071 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128810609-128811109 Neighboring gene tumor protein p53 regulated apoptosis inducing protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128840383-128840884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128840885-128841384 Neighboring gene Rho GTPase activating protein 32 Neighboring gene RNA, U6 small nuclear 876, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of potassium inwardly-rectifying channel, subfamily J, member 5 (KCNJ5) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of potassium inwardly-rectifying channel, subfamily J, member 5 (KCNJ5) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    G protein-activated inward rectifier potassium channel 4
    Names
    IRK-4
    cardiac ATP-sensitive potassium channel
    heart KATP channel
    inward rectifier K+ channel KIR3.4
    potassium channel, inwardly rectifying subfamily J, member 5
    potassium voltage-gated channel subfamily J member 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023406.2 RefSeqGene

      Range
      5001..31652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_333

    mRNA and Protein(s)

    1. NM_000890.5NP_000881.3  G protein-activated inward rectifier potassium channel 4

      See identical proteins and their annotated locations for NP_000881.3

      Status: REVIEWED

      Source sequence(s)
      AK312837, AP000920
      Consensus CDS
      CCDS8479.1
      UniProtKB/Swiss-Prot
      B2R744, P48544, Q6DK13, Q6DK14, Q92807
      UniProtKB/TrEMBL
      A0A5J6E2W8, H7CGH0
      Related
      ENSP00000433295.1, ENST00000529694.6
      Conserved Domains (2) summary
      pfam01007
      Location:54193
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:200371
      IRK_C; Inward rectifier potassium channel C-terminal domain
    2. NM_001354169.2NP_001341098.1  G protein-activated inward rectifier potassium channel 4

      Status: REVIEWED

      Source sequence(s)
      AP000920, BC069571, BX647543
      Consensus CDS
      CCDS8479.1
      UniProtKB/Swiss-Prot
      B2R744, P48544, Q6DK13, Q6DK14, Q92807
      UniProtKB/TrEMBL
      A0A5J6E2W8, H7CGH0
      Related
      ENSP00000339960.4, ENST00000338350.4
      Conserved Domains (2) summary
      pfam01007
      Location:54193
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:200371
      IRK_C; Inward rectifier potassium channel C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      128891356..128921163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542810.4XP_011541112.1  G protein-activated inward rectifier potassium channel 4 isoform X1

      See identical proteins and their annotated locations for XP_011541112.1

      UniProtKB/Swiss-Prot
      B2R744, P48544, Q6DK13, Q6DK14, Q92807
      UniProtKB/TrEMBL
      A0A5J6E2W8, H7CGH0
      Conserved Domains (2) summary
      pfam01007
      Location:54193
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:200371
      IRK_C; Inward rectifier potassium channel C-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      128926287..128956088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368729.1XP_054224704.1  G protein-activated inward rectifier potassium channel 4 isoform X1