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    SUCLG1 succinate-CoA ligase GDP/ADP-forming subunit alpha [ Homo sapiens (human) ]

    Gene ID: 8802, updated on 7-Sep-2023

    Summary

    Official Symbol
    SUCLG1provided by HGNC
    Official Full Name
    succinate-CoA ligase GDP/ADP-forming subunit alphaprovided by HGNC
    Primary source
    HGNC:HGNC:11449
    See related
    Ensembl:ENSG00000163541 MIM:611224; AllianceGenome:HGNC:11449
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GALPHA; MTDPS9; SUCLA1
    Summary
    This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010]
    Expression
    Broad expression in kidney (RPKM 188.3), duodenum (RPKM 98.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SUCLG1 in Genome Data Viewer
    Location:
    2p11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (84423528..84459280, complement)
    RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (84425228..84460977, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (84650652..84686404, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 pseudogene 1 Neighboring gene uncharacterized LOC107985905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:84445877-84446376 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:84517185-84518384 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:84524005-84525204 Neighboring gene FUN14 domain containing 2 pseudogene 2 Neighboring gene dynein axonemal heavy chain 6 Neighboring gene ubiquitin specific peptidase 26 pseudogene Neighboring gene double homeobox A pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of succinate-CoA ligase, alpha subunit (SUCLG1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21114, FLJ43513

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables succinate-CoA ligase (ADP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables succinate-CoA ligase (GDP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in succinyl-CoA catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tricarboxylic acid cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of succinate-CoA ligase complex (ADP-forming) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of succinate-CoA ligase complex (ADP-forming) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of succinate-CoA ligase complex (GDP-forming) IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
    Names
    SCS-alpha
    mitochondrial succinate--CoA ligase [ADP/GDP-forming] subunit alpha
    succinate-CoA ligase alpha subunit
    succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
    succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial
    succinyl-CoA synthetase subunit alpha
    NP_003840.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016755.1 RefSeqGene

      Range
      5183..40935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003849.4NP_003840.2  succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial precursor

      See identical proteins and their annotated locations for NP_003840.2

      Status: REVIEWED

      Source sequence(s)
      AC096770, BC000504, BP194715, BQ774501
      Consensus CDS
      CCDS1967.2
      UniProtKB/Swiss-Prot
      P53597, Q9BWB0, Q9UNP6
      UniProtKB/TrEMBL
      Q6IAL5
      Related
      ENSP00000377446.2, ENST00000393868.7
      Conserved Domains (3) summary
      PTZ00187
      Location:19344
      PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional
      pfam02629
      Location:53146
      CoA_binding; CoA binding domain
      cl22543
      Location:199324
      Ligase_CoA; CoA-ligase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      84423528..84459280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      84425228..84460977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)