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    STAMBP STAM binding protein [ Homo sapiens (human) ]

    Gene ID: 10617, updated on 7-Jul-2024

    Summary

    Official Symbol
    STAMBPprovided by HGNC
    Official Full Name
    STAM binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:16950
    See related
    Ensembl:ENSG00000124356 MIM:606247; AllianceGenome:HGNC:16950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AMSH; MICCAP
    Summary
    Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 4.9), brain (RPKM 4.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STAMBP in Genome Data Viewer
    Location:
    2p13.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (73828961..73873656)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (73837148..73881820)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74056088..74100783)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16034 Neighboring gene chromosome 2 open reading frame 78 Neighboring gene uncharacterized LOC105374807 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:74055859-74056077 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:74057585-74058784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16035 Neighboring gene uncharacterized LOC112268419 Neighboring gene zinc finger DHHC-type palmitoyltransferase 6 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:74119211-74120024 Neighboring gene actin gamma 2, smooth muscle Neighboring gene ReSE screen-validated silencer GRCh37_chr2:74139533-74139680

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126516, MGC126518

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables K63-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal-dependent deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    STAM-binding protein
    Names
    associated molecule with the SH3 domain of STAM
    endosome-associated ubiquitin isopeptidase
    testicular secretory protein Li 54
    NP_001340896.1
    NP_001340897.1
    NP_001340898.1
    NP_001340899.1
    NP_001340900.1
    NP_001340901.1
    NP_001340902.1
    NP_001340903.1
    NP_001340904.1
    NP_001340905.1
    NP_006454.1
    NP_964010.1
    NP_998787.1
    XP_011530787.1
    XP_047298917.1
    XP_047298918.1
    XP_047298919.1
    XP_047298920.1
    XP_047298924.1
    XP_047298926.1
    XP_047298927.1
    XP_047298928.1
    XP_047298929.1
    XP_047298930.1
    XP_054196176.1
    XP_054196177.1
    XP_054196178.1
    XP_054196179.1
    XP_054196180.1
    XP_054196181.1
    XP_054196182.1
    XP_054196183.1
    XP_054196184.1
    XP_054196185.1
    XP_054196186.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033223.2 RefSeqGene

      Range
      5051..43258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001353967.2NP_001340896.1  STAM-binding protein isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC073046
      Consensus CDS
      CCDS1929.1
      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
      Related
      ENSP00000507054.1, ENST00000684585.1
      Conserved Domains (2) summary
      cd08066
      Location:254424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:7114
      USP8_dimer; USP8 dimerisation domain
    2. NM_001353968.2NP_001340897.1  STAM-binding protein isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC073046
      Consensus CDS
      CCDS1929.1
      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
      Related
      ENSP00000506833.1, ENST00000682351.1
      Conserved Domains (2) summary
      cd08066
      Location:254424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:7114
      USP8_dimer; USP8 dimerisation domain
    3. NM_001353969.2NP_001340898.1  STAM-binding protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC073046
      Consensus CDS
      CCDS92778.1
      UniProtKB/TrEMBL
      A0A804HII8, A0A804HKA6
      Related
      ENSP00000507807.1, ENST00000683349.1
      Conserved Domains (2) summary
      cd08066
      Location:254405
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:7114
      USP8_dimer; USP8 dimerisation domain
    4. NM_001353970.2NP_001340899.1  STAM-binding protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC073046
      Consensus CDS
      CCDS92778.1
      UniProtKB/TrEMBL
      A0A804HII8, A0A804HKA6
      Related
      ENSP00000507089.1, ENST00000682799.1
      Conserved Domains (2) summary
      cd08066
      Location:254405
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:7114
      USP8_dimer; USP8 dimerisation domain
    5. NM_001353971.2NP_001340900.1  STAM-binding protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC073046
      Consensus CDS
      CCDS92779.1
      UniProtKB/TrEMBL
      A0A804HJ64
      Conserved Domains (1) summary
      cd08066
      Location:119289
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
    6. NM_001353972.2NP_001340901.1  STAM-binding protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC073046
      Consensus CDS
      CCDS92779.1
      UniProtKB/TrEMBL
      A0A804HJ64
      Related
      ENSP00000507371.1, ENST00000682851.1
      Conserved Domains (1) summary
      cd08066
      Location:119289
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
    7. NM_001353973.2NP_001340902.1  STAM-binding protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC073046
      Consensus CDS
      CCDS92779.1
      UniProtKB/TrEMBL
      A0A804HJ64
      Conserved Domains (1) summary
      cd08066
      Location:119289
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
    8. NM_001353974.2NP_001340903.1  STAM-binding protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC073046
      Consensus CDS
      CCDS92779.1
      UniProtKB/TrEMBL
      A0A804HJ64
      Related
      ENST00000683465.1
      Conserved Domains (1) summary
      cd08066
      Location:119289
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
    9. NM_001353975.2NP_001340904.1  STAM-binding protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC073046
      Consensus CDS
      CCDS92779.1
      UniProtKB/TrEMBL
      A0A804HJ64
      Conserved Domains (1) summary
      cd08066
      Location:119289
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
    10. NM_001353976.2NP_001340905.1  STAM-binding protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC073046
      Conserved Domains (1) summary
      cd08066
      Location:119270
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
    11. NM_006463.6NP_006454.1  STAM-binding protein isoform 1

      See identical proteins and their annotated locations for NP_006454.1

      Status: REVIEWED

      Source sequence(s)
      AC073046, BC101467, DB477012, DR158757
      Consensus CDS
      CCDS1929.1
      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
      Related
      ENSP00000377636.1, ENST00000394073.6
      Conserved Domains (2) summary
      cd08066
      Location:254424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:7114
      USP8_dimer; USP8 dimerisation domain
    12. NM_201647.4NP_964010.1  STAM-binding protein isoform 1

      See identical proteins and their annotated locations for NP_964010.1

      Status: REVIEWED

      Source sequence(s)
      AC073046, DN919763, U73522
      Consensus CDS
      CCDS1929.1
      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
      Related
      ENSP00000344742.3, ENST00000339566.7
      Conserved Domains (2) summary
      cd08066
      Location:254424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:7114
      USP8_dimer; USP8 dimerisation domain
    13. NM_213622.4NP_998787.1  STAM-binding protein isoform 1

      See identical proteins and their annotated locations for NP_998787.1

      Status: REVIEWED

      Source sequence(s)
      AC073046, BC065574, CX758449
      Consensus CDS
      CCDS1929.1
      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
      Related
      ENSP00000377633.2, ENST00000394070.7
      Conserved Domains (2) summary
      cd08066
      Location:254424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:7114
      USP8_dimer; USP8 dimerisation domain

    RNA

    1. NR_148668.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073046
    2. NR_148669.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073046
      Related
      ENST00000478946.2
    3. NR_148670.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073046
    4. NR_148671.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073046
      Related
      ENST00000683417.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      73828961..73873656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442964.1XP_047298920.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
      Related
      ENSP00000506958.1, ENST00000684312.1
    2. XM_047442961.1XP_047298917.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
    3. XM_047442970.1XP_047298926.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
    4. XM_047442971.1XP_047298927.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
      Related
      ENSP00000507081.1, ENST00000682379.1
    5. XM_047442963.1XP_047298919.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
    6. XM_047442962.1XP_047298918.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
      Related
      ENSP00000507864.1, ENST00000682847.1
    7. XM_047442968.1XP_047298924.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
      Related
      ENSP00000386548.1, ENST00000409707.6
    8. XM_047442974.1XP_047298930.1  STAM-binding protein isoform X3

      UniProtKB/TrEMBL
      A0A804HJ64
    9. XM_011532485.4XP_011530787.1  STAM-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A804HI64, A0A804HIF8
      Conserved Domains (2) summary
      pfam08969
      Location:13114
      USP8_dimer; USP8 dimerization domain
      cl13996
      Location:254335
      MPN; Mpr1p, Pad1p N-terminal (MPN) domains
    10. XM_047442973.1XP_047298929.1  STAM-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A804HI64, A0A804HIF8
      Related
      ENSP00000507046.1, ENST00000682998.1
    11. XM_047442972.1XP_047298928.1  STAM-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A804HI64, A0A804HIF8
      Related
      ENSP00000413874.3, ENST00000432295.7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      73837148..73881820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340204.1XP_054196179.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
    2. XM_054340201.1XP_054196176.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
    3. XM_054340203.1XP_054196178.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
    4. XM_054340202.1XP_054196177.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
    5. XM_054340206.1XP_054196181.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
    6. XM_054340207.1XP_054196182.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
    7. XM_054340205.1XP_054196180.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B5M0B6, D6W5H7, O95630, Q3MJE7
      UniProtKB/TrEMBL
      A0A140VK54, A0A804HJS0
    8. XM_054340211.1XP_054196186.1  STAM-binding protein isoform X3

      UniProtKB/TrEMBL
      A0A804HJ64
    9. XM_054340208.1XP_054196183.1  STAM-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A804HI64, A0A804HIF8
    10. XM_054340210.1XP_054196185.1  STAM-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A804HI64, A0A804HIF8
    11. XM_054340209.1XP_054196184.1  STAM-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A804HI64, A0A804HIF8