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    NRXN1 neurexin 1 [ Homo sapiens (human) ]

    Gene ID: 9378, updated on 20-Jun-2024

    Summary

    Official Symbol
    NRXN1provided by HGNC
    Official Full Name
    neurexin 1provided by HGNC
    Primary source
    HGNC:HGNC:8008
    See related
    Ensembl:ENSG00000179915 MIM:600565; AllianceGenome:HGNC:8008
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTHSL2; SCZD17; Hs.22998
    Summary
    This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]
    Expression
    Biased expression in brain (RPKM 12.7) and testis (RPKM 0.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NRXN1 in Genome Data Viewer
    Location:
    2p16.3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (49918503..51032132, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (49914520..51028290, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (50145641..51259270, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124906005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:49999711-50000210 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:50163910-50164578 Neighboring gene VISTA enhancer hs2343 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:50231574-50232307 Neighboring gene ribosomal protein L7 pseudogene 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:50311271-50311784 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:50311785-50312297 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:50572921-50573860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:50573861-50574798 Neighboring gene MPRA-validated peak3699 silencer Neighboring gene VISTA enhancer hs1348 Neighboring gene uncharacterized LOC101927089 Neighboring gene MT-CO1 pseudogene 42 Neighboring gene uncharacterized LOC124906006 Neighboring gene microRNA 8485 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:51227905-51228438 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:51240083-51240639 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:51254469-51255168 Neighboring gene NRXN1 divergent transcript Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:51483602-51484801 Neighboring gene uncharacterized LOC105377627 Neighboring gene lysine rich nucleolar protein 1 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Chromosome 2p16.3 deletion syndrome
    MedGen: C3808494 OMIM: 614332 GeneReviews: Not available
    Compare labs
    Pitt-Hopkins-like syndrome 2
    MedGen: C3280479 OMIM: 614325 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2021-06-08)

    ClinGen Genome Curation PagePubMed
    Triplosensitivity

    No evidence available (Last evaluated 2021-06-08)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    A genome-wide association study of behavioral disinhibition.
    EBI GWAS Catalog
    A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality.
    EBI GWAS Catalog
    A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
    EBI GWAS Catalog
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    EBI GWAS Catalog
    Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.
    EBI GWAS Catalog
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog
    Joint influence of small-effect genetic variants on human longevity.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of neurexin 1 (NRXN1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ35941, KIAA0578, DKFZp313P2036

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acetylcholine receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cell adhesion molecule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuroligin family protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables neuroligin family protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transmembrane signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables type 1 fibroblast growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in NMDA glutamate receptor clustering ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in axon guidance TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cerebellar granule cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chemical synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in gamma-aminobutyric acid receptor clustering ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in gephyrin clustering involved in postsynaptic density assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in guanylate kinase-associated protein clustering ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuroligin clustering involved in postsynaptic membrane assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of neuromuscular process controlling balance ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in neuron cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron cell-cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neuronal signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neurotransmitter secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of presynaptic active zone assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of protein kinase A signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein kinase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of synapse assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of synapse maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of synaptic transmission, glutamatergic ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in postsynaptic density protein 95 clustering ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in postsynaptic membrane assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in presynaptic membrane assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein-containing complex assembly involved in synapse maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in receptor localization to synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of AMPA receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of NMDA receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synaptic vesicle clustering ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vocal learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vocalization behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axonal growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in presynapse NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in presynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in presynaptic membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    neurexin-1
    Names
    neurexin I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011878.1 RefSeqGene

      Range
      5405..1119034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001135659.3NP_001129131.1  neurexin-1 isoform alpha2 precursor

      See identical proteins and their annotated locations for NP_001129131.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha2) results from the use of the 5'-most promoter, referred to as alpha. It represents the longest transcript that encodes the longest isoform (alpha2) of the representative RefSeq variants. This isoform contains EGF-like, several laminin G, and syndecan domains.
      Source sequence(s)
      AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
      Consensus CDS
      CCDS46282.1
      UniProtKB/TrEMBL
      A0A0R4J2G7
      Related
      ENSP00000385142.1, ENST00000404971.5
      Conserved Domains (6) summary
      smart00294
      Location:14921510
      4.1m; putative band 4.1 homologues' binding motif
      smart00282
      Location:543692
      LamG; Laminin G domain
      cd00054
      Location:720753
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:30190
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam01034
      Location:14721511
      Syndecan; Syndecan domain
      pfam02210
      Location:9731101
      Laminin_G_2; Laminin G domain
    2. NM_001320156.4NP_001307085.1  neurexin-1 isoform gamma1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (gamma1) results from the use of an alternate promoter, referred to as gamma. It contains an alternate 5' terminal exon and lacks all the exons, except the last two 3' terminal exons, compared to variant alpha2. Hence, the encoded isoform (gamma1) is considerably shorter with a distinct N-terminus lacking the EGF-like and laminin G domains, and containing only the syndecan domain compared to isoform alpha2.
      Source sequence(s)
      AC078994
      Consensus CDS
      CCDS82444.1
      UniProtKB/TrEMBL
      A0A1B0GTL0, H7BYC7
      Related
      ENSP00000367510.4, ENST00000378262.7
      Conserved Domains (2) summary
      smart00294
      Location:87105
      4.1m; putative band 4.1 homologues' binding motif
      pfam01034
      Location:67106
      Syndecan; Syndecan domain
    3. NM_001320157.4NP_001307086.1  neurexin-1 isoform gamma2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (gamma2) results from the use of an alternate promoter, referred to as gamma. It contains an alternate 5' terminal exon and lacks all the exons, except the last two 3' terminal exons (the penultimate exon uses an alternate in-frame donor splice site), compared to variant alpha2. Hence, the encoded isoform (gamma2) is considerably shorter with a distinct N-terminus lacking the EGF-like and laminin G domains, and containing only the syndecan domain compared to isoform alpha2.
      Source sequence(s)
      AC078994
      Consensus CDS
      CCDS82445.1
      UniProtKB/TrEMBL
      A0A1B0GTL0, H0Y568
      Related
      ENSP00000396738.2, ENST00000412315.5
      Conserved Domains (2) summary
      smart00294
      Location:84102
      4.1m; putative band 4.1 homologues' binding motif
      pfam01034
      Location:64103
      Syndecan; Syndecan domain
    4. NM_001330077.2NP_001317006.1  neurexin-1 isoform alpha3 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
      Consensus CDS
      CCDS82449.1
      UniProtKB/TrEMBL
      A0A0R4J2G7, A0A1D5RMU6
      Related
      ENSP00000486879.1, ENST00000630543.2
      Conserved Domains (6) summary
      smart00294
      Location:14441462
      4.1m; putative band 4.1 homologues' binding motif
      smart00282
      Location:495644
      LamG; Laminin G domain
      cd00054
      Location:672705
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:30190
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam01034
      Location:14241463
      Syndecan; Syndecan domain
      pfam02210
      Location:9251053
      Laminin_G_2; Laminin G domain
    5. NM_001330078.2NP_001317007.1  neurexin-1 isoform alpha4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
      Consensus CDS
      CCDS82451.1
      UniProtKB/TrEMBL
      A0A0R4J2G7, E7ERL8
      Related
      ENSP00000385017.2, ENST00000401669.7
      Conserved Domains (6) summary
      smart00294
      Location:14521470
      4.1m; putative band 4.1 homologues' binding motif
      smart00282
      Location:503652
      LamG; Laminin G domain
      cd00054
      Location:680713
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:30190
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam01034
      Location:14321471
      Syndecan; Syndecan domain
      pfam02210
      Location:9331061
      Laminin_G_2; Laminin G domain
    6. NM_001330079.2NP_001317008.1  neurexin-1 isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks multiple 3' coding exons and contains an alternate 3' terminal exon compared to variant alpha2. The encoded isoform (6) is much shorter than isoform alpha2.
      Source sequence(s)
      AC007682
      Consensus CDS
      CCDS86838.1
      UniProtKB/TrEMBL
      A0A0D9SEQ7, Q49A31
      Related
      ENSP00000485912.1, ENST00000626899.1
      Conserved Domains (1) summary
      cd00110
      Location:30190
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    7. NM_001330081.2NP_001317010.1  neurexin-1 isoform 7 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks multiple 3' coding exons and contains an alternate 3' terminal exon compared to variant alpha2. The encoded isoform (7) is much shorter than isoform alpha2.
      Source sequence(s)
      AC007682
      Consensus CDS
      CCDS86840.1
      UniProtKB/TrEMBL
      E7EQN4, Q49A31
      Related
      ENSP00000385310.1, ENST00000405581.3
      Conserved Domains (1) summary
      cd00110
      Location:30190
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    8. NM_001330082.2NP_001317011.1  neurexin-1 isoform alpha5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
      Consensus CDS
      CCDS82450.1
      UniProtKB/TrEMBL
      A0A0R4J2G7
      Related
      ENSP00000485887.1, ENST00000625672.2
      Conserved Domains (6) summary
      smart00294
      Location:14411459
      4.1m; putative band 4.1 homologues' binding motif
      smart00282
      Location:495644
      LamG; Laminin G domain
      cd00054
      Location:672705
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:30190
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam01034
      Location:14211460
      Syndecan; Syndecan domain
      pfam02210
      Location:9251053
      Laminin_G_2; Laminin G domain
    9. NM_001330083.2NP_001317012.1  neurexin-1 isoform alpha6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
      UniProtKB/TrEMBL
      A0A0R4J2G7
    10. NM_001330084.2NP_001317013.1  neurexin-1 isoform alpha7 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
      UniProtKB/TrEMBL
      A0A0R4J2G7
    11. NM_001330085.2NP_001317014.1  neurexin-1 isoform alpha8 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
      UniProtKB/TrEMBL
      A0A0R4J2G7
    12. NM_001330086.2NP_001317015.1  neurexin-1 isoform alpha9 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
      UniProtKB/TrEMBL
      A0A0R4J2G7
    13. NM_001330087.2NP_001317016.1  neurexin-1 isoform alpha10 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
      UniProtKB/TrEMBL
      A0A0R4J2G7
    14. NM_001330088.2NP_001317017.1  neurexin-1 isoform alpha11 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
      UniProtKB/TrEMBL
      A0A0R4J2G7
    15. NM_001330089.2NP_001317018.1  neurexin-1 isoform 8 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks multiple 3' coding exons and contains an alternate 3' exon structure compared to variant alpha2. The encoded isoform (8) is much shorter than isoform alpha2 and has a distinct C-terminus.
      Source sequence(s)
      AC007682, BX113737
      UniProtKB/TrEMBL
      Q49A31
      Conserved Domains (1) summary
      cd00110
      Location:30190
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    16. NM_001330090.2NP_001317019.1  neurexin-1 isoform 9 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks multiple 3' coding exons and contains an alternate 3' terminal exon compared to variant alpha2. The encoded isoform (9) is much shorter than isoform alpha2 and has a distinct C-terminus.
      Source sequence(s)
      AC007682
      UniProtKB/TrEMBL
      Q49A31
      Related
      ENSP00000490494.1, ENST00000637511.1
    17. NM_001330091.2NP_001317020.1  neurexin-1 isoform beta2

      Status: REVIEWED

      Source sequence(s)
      AC068725, AC069550, AC078994
      Consensus CDS
      CCDS82447.1
      UniProtKB/TrEMBL
      A0A0D9SEM5
      Related
      ENSP00000485815.1, ENST00000628364.2
    18. NM_001330092.2NP_001317021.1  neurexin-1 isoform beta3

      Status: REVIEWED

      Source sequence(s)
      AC068725, AC069550, AC078994
      Consensus CDS
      CCDS82446.1
      UniProtKB/Swiss-Prot
      E7ETA5, P58400
      Related
      ENSP00000385580.2, ENST00000401710.5
      Conserved Domains (3) summary
      smart00294
      Location:417435
      4.1m; putative band 4.1 homologues' binding motif
      cd00110
      Location:90209
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam01034
      Location:397436
      Syndecan; Syndecan domain
    19. NM_001330093.2NP_001317022.1  neurexin-1 isoform alpha12 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
      UniProtKB/TrEMBL
      A0A0R4J2G7
    20. NM_001330094.2NP_001317023.1  neurexin-1 isoform alpha13 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
      UniProtKB/TrEMBL
      A0A0R4J2G7
    21. NM_001330095.2NP_001317024.1  neurexin-1 isoform alpha14 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
      UniProtKB/TrEMBL
      A0A0R4J2G7
    22. NM_001330096.2NP_001317025.1  neurexin-1 isoform alpha15 precursor

      Status: REVIEWED

      Source sequence(s)
      AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
      UniProtKB/TrEMBL
      A0A0R4J2G7
    23. NM_001330097.2NP_001317026.1  neurexin-1 isoform beta4

      Status: REVIEWED

      Source sequence(s)
      AC068725, AC069550, AC078994
      UniProtKB/TrEMBL
      A4FVB9
    24. NM_004801.6NP_004792.1  neurexin-1 isoform alpha1 precursor

      See identical proteins and their annotated locations for NP_004792.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha1) results from the use of the 5'-most promoter, referred to as alpha. It lacks two in-frame exons and uses an alternate in-frame donor splice site at an internal exon compared to variant alpha2. The resulting isoform (alpha1) is shorter missing a few internal protein segments compared to isoform alpha2. This isoform contains EGF-like, several laminin G, and syndecan domains.
      Source sequence(s)
      AC007462, AC007682, AC009234, AC068725, AC069550, AC078994
      Consensus CDS
      CCDS54360.1
      UniProtKB/Swiss-Prot
      A7KRL9, O60323, Q53TJ9, Q53TQ1, Q5HYI0, Q9C079, Q9C080, Q9C081, Q9H3M2, Q9UDM6, Q9ULB1
      UniProtKB/TrEMBL
      A0A0R4J2G7
      Related
      ENSP00000384311.2, ENST00000406316.6
      Conserved Domains (6) summary
      smart00294
      Location:14221440
      4.1m; putative band 4.1 homologues' binding motif
      smart00282
      Location:503652
      LamG; Laminin G domain
      cd00054
      Location:680713
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:30190
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam01034
      Location:14021441
      Syndecan; Syndecan domain
      pfam02210
      Location:9331061
      Laminin_G_2; Laminin G domain
    25. NM_138735.5NP_620072.1  neurexin-1 isoform beta1

      See identical proteins and their annotated locations for NP_620072.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta1) results from the use of an alternate promoter, referred to as beta. It contains an alternate 5' terminal exon and lacks most of the 5' exons and another exon in the 3' region compared to variant alpha2. The resulting isoform (beta1) is shorter with a distinct N-terminus lacking the EGF-like domain and containing fewer laminin G domains compared to isoform alpha2.
      Source sequence(s)
      AC068725, AC069550, AC078994
      Consensus CDS
      CCDS1845.1
      UniProtKB/TrEMBL
      A4FVB9
      Related
      ENSP00000341184.5, ENST00000342183.9
      Conserved Domains (3) summary
      smart00294
      Location:387405
      4.1m; putative band 4.1 homologues' binding motif
      pfam01034
      Location:367406
      Syndecan; Syndecan domain
      pfam02210
      Location:121239
      Laminin_G_2; Laminin G domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      49918503..51032132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      49914520..51028290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)