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    MYBPC1 myosin binding protein C1 [ Homo sapiens (human) ]

    Gene ID: 4604, updated on 9-Jun-2024

    Summary

    Official Symbol
    MYBPC1provided by HGNC
    Official Full Name
    myosin binding protein C1provided by HGNC
    Primary source
    HGNC:HGNC:7549
    See related
    Ensembl:ENSG00000196091 MIM:160794; AllianceGenome:HGNC:7549
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LCCS4; CMYP16; MYBPCC; MYBPCS; MYOTREM; ssMyBP-C
    Summary
    This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
    Expression
    Biased expression in prostate (RPKM 75.7), esophagus (RPKM 49.2) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MYBPC1 in Genome Data Viewer
    Location:
    12q23.2
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (101594971..101695841)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (101556082..101657067)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (101988749..102079806)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Spi-C transcription factor Neighboring gene uncharacterized LOC105369935 Neighboring gene Sharpr-MPRA regulatory region 598 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:101974951-101975478 Neighboring gene uncharacterized LOC105369938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4768 Neighboring gene uncharacterized LOC105369937 Neighboring gene uncharacterized LOC124902996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6864 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4770 Neighboring gene choline phosphotransferase 1 Neighboring gene RNY1 pseudogene 16 Neighboring gene synaptonemal complex protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Arthrogryposis, distal, type 1B
    MedGen: C3280526 OMIM: 614335 GeneReviews: Not available
    Compare labs
    Lethal congenital contracture syndrome 4
    MedGen: C3554046 OMIM: 614915 GeneReviews: Not available
    Compare labs
    Myopathy, congenital, with tremor
    MedGen: C5231401 OMIM: 618524 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Gene network analysis in a pediatric cohort identifies novel lung function genes.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of muscle TAS
    Traceable Author Statement
    more info
    PubMed 
    enables titin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in myofibril ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    myosin-binding protein C, slow-type
    Names
    myosin binding protein C, slow type
    skeletal muscle C-protein
    slow MyBP-C
    slow skeletal-type muscle myosin-binding-protein C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031912.2 RefSeqGene

      Range
      5002..96059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001254718.3NP_001241647.1  myosin-binding protein C, slow-type isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks three exons and includes an alternate exon in the coding region, compared to variant 1. The encoded isoform (5) is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC010205, AC090671, AC117505
      Consensus CDS
      CCDS58268.1
      UniProtKB/TrEMBL
      F8VZY0
      Related
      ENSP00000400908.2, ENST00000452455.6
      Conserved Domains (7) summary
      cd00096
      Location:10641129
      Ig; Immunoglobulin domain
      cd05894
      Location:531616
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:356414
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:534616
      IG_like; Immunoglobulin like
      cd00063
      Location:620710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10471136
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:857928
      Ig; Immunoglobulin domain
    2. NM_001254719.3NP_001241648.1  myosin-binding protein C, slow-type isoform 6

      See identical proteins and their annotated locations for NP_001241648.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
      Source sequence(s)
      AC010205, AC090671, AC117505
      Consensus CDS
      CCDS58269.1
      UniProtKB/TrEMBL
      F8VZE0
      Related
      ENSP00000440034.2, ENST00000545503.6
      Conserved Domains (7) summary
      cd00096
      Location:10461111
      Ig; Immunoglobulin domain
      cd05894
      Location:531616
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:356414
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:534616
      IG_like; Immunoglobulin like
      cd00063
      Location:620710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10291118
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:839910
      Ig; Immunoglobulin domain
    3. NM_001254720.3NP_001241649.1  myosin-binding protein C, slow-type isoform 7

      See identical proteins and their annotated locations for NP_001241649.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks three exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (7) is shorter than isoform 1.
      Source sequence(s)
      AC010205, AC090671, AC117505
      Consensus CDS
      CCDS58271.1
      UniProtKB/TrEMBL
      F8VZE0
      Related
      ENSP00000442847.1, ENST00000541119.5
      Conserved Domains (7) summary
      cd00096
      Location:10341099
      Ig; Immunoglobulin domain
      cd05894
      Location:519604
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:344402
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:522604
      IG_like; Immunoglobulin like
      cd00063
      Location:608698
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10171106
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:827898
      Ig; Immunoglobulin domain
    4. NM_001254721.3NP_001241650.1  myosin-binding protein C, slow-type isoform 8

      See identical proteins and their annotated locations for NP_001241650.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks three exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (8) is shorter than isoform 1.
      Source sequence(s)
      AC010205, AC090671, AC117505
      Consensus CDS
      CCDS58270.1
      UniProtKB/TrEMBL
      F8VZE0
      Related
      ENSP00000446128.1, ENST00000536007.5
      Conserved Domains (7) summary
      cd00096
      Location:10271092
      Ig; Immunoglobulin domain
      cd05894
      Location:512597
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:337395
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:515597
      IG_like; Immunoglobulin like
      cd00063
      Location:601691
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10101099
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:820891
      Ig; Immunoglobulin domain
    5. NM_001254722.3NP_001241651.1  myosin-binding protein C, slow-type isoform 9

      See identical proteins and their annotated locations for NP_001241651.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks four consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (9) is shorter than isoform 1.
      Source sequence(s)
      AC010205, AC090671, AC117505
      Consensus CDS
      CCDS58273.1
      UniProtKB/TrEMBL
      F8VZE0
      Related
      ENSP00000448175.1, ENST00000547405.5
      Conserved Domains (7) summary
      cd00096
      Location:10201085
      Ig; Immunoglobulin domain
      cd05894
      Location:505590
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:330388
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:508590
      IG_like; Immunoglobulin like
      cd00063
      Location:594684
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10031092
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:813884
      Ig; Immunoglobulin domain
    6. NM_001254723.3NP_001241652.1  myosin-binding protein C, slow-type isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks five exons in the coding region, compared to variant 1. The encoded isoform (10) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC010205, AC090671, AC117505
      Consensus CDS
      CCDS58272.1
      UniProtKB/TrEMBL
      F8VZE0
      Related
      ENSP00000376665.3, ENST00000392934.7
      Conserved Domains (7) summary
      cd00096
      Location:10331098
      Ig; Immunoglobulin domain
      cd05894
      Location:518603
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:343401
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:521603
      IG_like; Immunoglobulin like
      cd00063
      Location:607697
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10161105
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:826897
      Ig; Immunoglobulin domain
    7. NM_001404675.1NP_001391604.1  myosin-binding protein C, slow-type isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC010205, AC090671, AC117505
      UniProtKB/TrEMBL
      Q86TA8
    8. NM_001404676.1NP_001391605.1  myosin-binding protein C, slow-type isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC010205, AC090671, AC117505
      UniProtKB/TrEMBL
      F8VZE0
    9. NM_001404677.1NP_001391606.1  myosin-binding protein C, slow-type isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC010205, AC090671, AC117505
      UniProtKB/TrEMBL
      F8VZE0
    10. NM_001404678.1NP_001391607.1  myosin-binding protein C, slow-type isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC010205, AC090671, AC117505
      UniProtKB/TrEMBL
      A8KAB1, Q8N3R4
    11. NM_001404679.1NP_001391608.1  myosin-binding protein C, slow-type isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC010205, AC090671, AC117505
      UniProtKB/TrEMBL
      F8VZE0
    12. NM_001404680.1NP_001391609.1  myosin-binding protein C, slow-type isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC010205, AC090671, AC117505
      UniProtKB/TrEMBL
      F8VZE0
      Related
      ENSP00000447116.1, ENST00000551300.5
    13. NM_001404681.1NP_001391610.1  myosin-binding protein C, slow-type isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC010205, AC090671, AC117505
      UniProtKB/TrEMBL
      F8VZE0
    14. NM_002465.4NP_002456.2  myosin-binding protein C, slow-type isoform 1

      See identical proteins and their annotated locations for NP_002456.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC010205, AK295727, AL831993, AL832456, BC030980, DA433791
      Consensus CDS
      CCDS9083.1
      UniProtKB/TrEMBL
      Q86TA8
      Related
      ENSP00000354849.2, ENST00000361466.7
      Conserved Domains (7) summary
      cd00096
      Location:10711136
      Ig; Immunoglobulin domain
      cd05894
      Location:556641
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:381439
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:559641
      IG_like; Immunoglobulin like
      cd00063
      Location:645735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10541143
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:864935
      Ig; Immunoglobulin domain
    15. NM_206819.4NP_996555.1  myosin-binding protein C, slow-type isoform 2

      See identical proteins and their annotated locations for NP_996555.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. the encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC010205, AC090671, AC117505
      Consensus CDS
      CCDS9084.1
      UniProtKB/TrEMBL
      A8KAB1, Q8N3R4
      Related
      ENSP00000354845.2, ENST00000361685.6
      Conserved Domains (7) summary
      cd00096
      Location:10711136
      Ig; Immunoglobulin domain
      cd05894
      Location:556641
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:381439
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:559641
      IG_like; Immunoglobulin like
      cd00063
      Location:645735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10541143
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:864935
      Ig; Immunoglobulin domain
    16. NM_206820.4NP_996556.1  myosin-binding protein C, slow-type isoform 3

      See identical proteins and their annotated locations for NP_996556.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks three exons and includes an alternate exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC010205, AC090671, AC117505
      Consensus CDS
      CCDS9085.1
      UniProtKB/Swiss-Prot
      B4DKR5, B7Z8G8, B7ZL02, B7ZL09, B7ZL10, E7ESM5, E7EWS6, G3XAE8, Q00872, Q15497, Q17RR7, Q569K7, Q86T48, Q86TC8, Q8N3L2
      UniProtKB/TrEMBL
      F8VZY0
      Related
      ENSP00000449702.1, ENST00000550270.1
      Conserved Domains (7) summary
      cd00096
      Location:10641129
      Ig; Immunoglobulin domain
      cd05894
      Location:531616
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:356414
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:534616
      IG_like; Immunoglobulin like
      cd00063
      Location:620710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10471136
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:857928
      Ig; Immunoglobulin domain
    17. NM_206821.4NP_996557.1  myosin-binding protein C, slow-type isoform 4

      See identical proteins and their annotated locations for NP_996557.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks three exons in the coding region compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to variant 1.
      Source sequence(s)
      AC010205, AC090671, AC117505
      Consensus CDS
      CCDS55877.1
      UniProtKB/TrEMBL
      A8KAB1, Q8N3R4
      Related
      ENSP00000447900.1, ENST00000553190.5
      Conserved Domains (7) summary
      cd00096
      Location:10461111
      Ig; Immunoglobulin domain
      cd05894
      Location:531616
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:356414
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:534616
      IG_like; Immunoglobulin like
      cd00063
      Location:620710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10291118
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:839910
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      101594971..101695841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019316.2XP_016874805.1  myosin-binding protein C, slow-type isoform X5

      UniProtKB/TrEMBL
      F8VZY0
    2. XM_006719406.5XP_006719469.1  myosin-binding protein C, slow-type isoform X2

      UniProtKB/TrEMBL
      Q86TA8
      Conserved Domains (7) summary
      cd00096
      Location:10891154
      Ig; Immunoglobulin domain
      cd05894
      Location:556641
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:381439
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:559641
      IG_like; Immunoglobulin like
      cd00063
      Location:645735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10721161
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:882953
      Ig; Immunoglobulin domain
    3. XM_006719410.5XP_006719473.1  myosin-binding protein C, slow-type isoform X7

      UniProtKB/TrEMBL
      F8VZY0
      Related
      ENSP00000447660.1, ENST00000549145.5
      Conserved Domains (7) summary
      cd00096
      Location:10891154
      Ig; Immunoglobulin domain
      cd05894
      Location:556641
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:381439
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:559641
      IG_like; Immunoglobulin like
      cd00063
      Location:645735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10721161
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:882953
      Ig; Immunoglobulin domain
    4. XM_006719405.5XP_006719468.1  myosin-binding protein C, slow-type isoform X1

      UniProtKB/TrEMBL
      F8VZY0
      Conserved Domains (7) summary
      cd00096
      Location:10891154
      Ig; Immunoglobulin domain
      cd05894
      Location:556641
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:381439
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:559641
      IG_like; Immunoglobulin like
      cd00063
      Location:645735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10721161
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:882953
      Ig; Immunoglobulin domain
    5. XM_017019315.3XP_016874804.1  myosin-binding protein C, slow-type isoform X4

      UniProtKB/TrEMBL
      F8VZY0
    6. XM_017019318.3XP_016874807.1  myosin-binding protein C, slow-type isoform X11

      UniProtKB/TrEMBL
      Q86TA8
    7. XM_006719407.4XP_006719470.1  myosin-binding protein C, slow-type isoform X3

      UniProtKB/TrEMBL
      F8VZY0
      Conserved Domains (7) summary
      cd00096
      Location:10771142
      Ig; Immunoglobulin domain
      cd05894
      Location:544629
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:369427
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:547629
      IG_like; Immunoglobulin like
      cd00063
      Location:633723
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10601149
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:870941
      Ig; Immunoglobulin domain
    8. XM_005268876.5XP_005268933.1  myosin-binding protein C, slow-type isoform X8

      UniProtKB/TrEMBL
      Q86TA8
      Conserved Domains (7) summary
      cd00096
      Location:10591124
      Ig; Immunoglobulin domain
      cd05894
      Location:544629
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:369427
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:547629
      IG_like; Immunoglobulin like
      cd00063
      Location:633723
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10421131
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:852923
      Ig; Immunoglobulin domain
    9. XM_006719411.4XP_006719474.1  myosin-binding protein C, slow-type isoform X9

      See identical proteins and their annotated locations for XP_006719474.1

      UniProtKB/TrEMBL
      F8VZE0
      Conserved Domains (7) summary
      cd00096
      Location:10641129
      Ig; Immunoglobulin domain
      cd05894
      Location:531616
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:356414
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:534616
      IG_like; Immunoglobulin like
      cd00063
      Location:620710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10471136
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:857928
      Ig; Immunoglobulin domain
    10. XM_006719409.4XP_006719472.1  myosin-binding protein C, slow-type isoform X6

      UniProtKB/TrEMBL
      F8VZY0
      Conserved Domains (7) summary
      cd00096
      Location:10641129
      Ig; Immunoglobulin domain
      cd05894
      Location:531616
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:356414
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:534616
      IG_like; Immunoglobulin like
      cd00063
      Location:620710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:10471136
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:857928
      Ig; Immunoglobulin domain
    11. XM_017019317.2XP_016874806.1  myosin-binding protein C, slow-type isoform X10

      UniProtKB/TrEMBL
      F8VZE0
    12. XM_017019319.3XP_016874808.1  myosin-binding protein C, slow-type isoform X12

      UniProtKB/TrEMBL
      F8VZY0
    13. XM_017019320.2XP_016874809.1  myosin-binding protein C, slow-type isoform X13

      UniProtKB/TrEMBL
      F8VZE0
    14. XM_047428875.1XP_047284831.1  myosin-binding protein C, slow-type isoform X14

      UniProtKB/TrEMBL
      F8VZE0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      101556082..101657067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372095.1XP_054228070.1  myosin-binding protein C, slow-type isoform X5

      UniProtKB/TrEMBL
      F8VZY0
    2. XM_054372092.1XP_054228067.1  myosin-binding protein C, slow-type isoform X2

      UniProtKB/TrEMBL
      Q86TA8
    3. XM_054372097.1XP_054228072.1  myosin-binding protein C, slow-type isoform X7

      UniProtKB/TrEMBL
      F8VZY0
    4. XM_054372091.1XP_054228066.1  myosin-binding protein C, slow-type isoform X1

      UniProtKB/TrEMBL
      F8VZY0
    5. XM_054372094.1XP_054228069.1  myosin-binding protein C, slow-type isoform X4

      UniProtKB/TrEMBL
      F8VZY0
    6. XM_054372101.1XP_054228076.1  myosin-binding protein C, slow-type isoform X11

      UniProtKB/TrEMBL
      Q86TA8
    7. XM_054372093.1XP_054228068.1  myosin-binding protein C, slow-type isoform X3

      UniProtKB/TrEMBL
      F8VZY0
    8. XM_054372098.1XP_054228073.1  myosin-binding protein C, slow-type isoform X8

      UniProtKB/TrEMBL
      Q86TA8
    9. XM_054372099.1XP_054228074.1  myosin-binding protein C, slow-type isoform X9

      UniProtKB/TrEMBL
      F8VZE0
    10. XM_054372096.1XP_054228071.1  myosin-binding protein C, slow-type isoform X6

      UniProtKB/TrEMBL
      F8VZY0
    11. XM_054372100.1XP_054228075.1  myosin-binding protein C, slow-type isoform X10

      UniProtKB/TrEMBL
      F8VZE0
    12. XM_054372102.1XP_054228077.1  myosin-binding protein C, slow-type isoform X12

      UniProtKB/TrEMBL
      F8VZY0
    13. XM_054372103.1XP_054228078.1  myosin-binding protein C, slow-type isoform X13

      UniProtKB/TrEMBL
      F8VZE0
    14. XM_054372104.1XP_054228079.1  myosin-binding protein C, slow-type isoform X14

      UniProtKB/TrEMBL
      F8VZE0