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    SLCO2A1 solute carrier organic anion transporter family member 2A1 [ Homo sapiens (human) ]

    Gene ID: 6578, updated on 17-Sep-2024

    Summary

    Official Symbol
    SLCO2A1provided by HGNC
    Official Full Name
    solute carrier organic anion transporter family member 2A1provided by HGNC
    Primary source
    HGNC:HGNC:10955
    See related
    Ensembl:ENSG00000174640 MIM:601460; AllianceGenome:HGNC:10955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGT; MATR1; PHOAD; PHOAR2; OATP2A1; SLC21A2
    Summary
    This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]
    Expression
    Broad expression in lung (RPKM 28.3), thyroid (RPKM 27.0) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLCO2A1 in Genome Data Viewer
    Location:
    3q22.1-q22.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (133932701..134029925, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (136677860..136775063, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (133651545..133748769, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SRP receptor subunit beta Neighboring gene ReSE screen-validated silencer GRCh37_chr3:133554421-133554601 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:133558716-133559216 Neighboring gene RAB6B, member RAS oncogene family Neighboring gene NANOG hESC enhancer GRCh37_chr3:133573718-133574219 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:133576178-133576792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133661421-133662009 Neighboring gene Sharpr-MPRA regulatory region 14374 Neighboring gene chromosome 3 putative open reading frame 36 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:133667965-133668933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133674467-133674998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133674999-133675528 Neighboring gene Sharpr-MPRA regulatory region 8475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133748764-133749264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133774934-133775740 Neighboring gene uncharacterized LOC105374117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133784850-133785350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133786727-133787227 Neighboring gene long intergenic non-protein coding RNA 2000

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of solute carrier organic anion transporter family, member 2A1 (SLCO2A1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lipid transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables prostaglandin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables prostaglandin transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in lipid transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in prostaglandin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium-independent organic anion transport TAS
    Traceable Author Statement
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier organic anion transporter family member 2A1
    Names
    matrin F/G 1
    solute carrier family 21 (prostaglandin transporter), member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031964.3 RefSeqGene

      Range
      27260..124484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_841

    mRNA and Protein(s)

    1. NM_005630.3NP_005621.2  solute carrier organic anion transporter family member 2A1

      See identical proteins and their annotated locations for NP_005621.2

      Status: REVIEWED

      Source sequence(s)
      AC080128, AC117475
      Consensus CDS
      CCDS3084.1
      UniProtKB/Swiss-Prot
      Q86V98, Q8IUN2, Q92959
      UniProtKB/TrEMBL
      E7EU40
      Related
      ENSP00000311291.4, ENST00000310926.11
      Conserved Domains (1) summary
      TIGR00805
      Location:1630
      oat; sodium-independent organic anion transporter

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      133932701..134029925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      136677860..136775063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)