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    ADGRE2 adhesion G protein-coupled receptor E2 [ Homo sapiens (human) ]

    Gene ID: 30817, updated on 4-Dec-2023

    Summary

    Official Symbol
    ADGRE2provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor E2provided by HGNC
    Primary source
    HGNC:HGNC:3337
    See related
    Ensembl:ENSG00000127507 MIM:606100; AllianceGenome:HGNC:3337
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VBU; CD97; EMR2; CD312
    Summary
    This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
    Expression
    Broad expression in appendix (RPKM 10.8), spleen (RPKM 6.1) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADGRE2 in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (14724171..14778560, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (14850478..14906112, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14843204..14889372, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 842, pseudogene Neighboring gene C-type lectin domain containing 17A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10261 Neighboring gene adhesion G protein-coupled receptor E3 Neighboring gene small nucleolar RNA, H/ACA box 104 Neighboring gene integrin subunit beta 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10263 Neighboring gene zinc finger protein 333 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:14841378-14842577 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14869525-14870048 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14870049-14870574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14884311-14884812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14179 Neighboring gene CRISPRi-validated cis-regulatory element chr19.2424 Neighboring gene TMEM167A pseudogene 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:14910875-14912074 Neighboring gene olfactory receptor family 7 subfamily C member 1 Neighboring gene olfactory receptor family 7 subfamily A member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp781B135

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chondroitin sulfate binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in leading edge membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    adhesion G protein-coupled receptor E2
    Names
    CD97 antigen
    EGF-like module-containing mucin-like hormone receptor-like 2
    Leukocyte antigen CD97
    egf-like module containing, mucin-like, hormone receptor-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047146.1 RefSeqGene

      Range
      4982..51150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001271052.1NP_001257981.1  adhesion G protein-coupled receptor E2 isoform h precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (h) is shorter than isoform a.
      Source sequence(s)
      AC005327, AC090427, AK298700, BC127004, CN480316
      Consensus CDS
      CCDS59361.1
      UniProtKB/TrEMBL
      A0JNV7
      Related
      ENSP00000376692.3, ENST00000392965.7
      Conserved Domains (4) summary
      cd00054
      Location:119154
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd15439
      Location:475737
      7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam07645
      Location:212243
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:186215
      cEGF; Complement Clr-like EGF-like
    2. NM_013447.4NP_038475.2  adhesion G protein-coupled receptor E2 isoform a precursor

      See identical proteins and their annotated locations for NP_038475.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC005327, AC090427, AK298700, BC127004, BG721006, CN480316
      Consensus CDS
      CCDS32935.1
      UniProtKB/Swiss-Prot
      B4DQ96, E7ESD7, E9PBR1, E9PEL6, E9PFQ5, E9PG91, Q8NG96, Q9UHX3, Q9Y4B1
      UniProtKB/TrEMBL
      A0JNV7
      Related
      ENSP00000319883.3, ENST00000315576.8
      Conserved Domains (4) summary
      smart00303
      Location:479529
      GPS; G-protein-coupled receptor proteolytic site domain
      cd00054
      Location:119154
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:163210
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:533774
      7tm_4; Olfactory receptor
    3. NM_152916.2NP_690880.1  adhesion G protein-coupled receptor E2 isoform b precursor

      Status: REVIEWED

      Source sequence(s)
      AC005327, AC090427
      Consensus CDS
      CCDS32934.1
      UniProtKB/TrEMBL
      A0JNV7
      Related
      ENSP00000470725.1, ENST00000594294.5
    4. NM_152917.2NP_690881.1  adhesion G protein-coupled receptor E2 isoform c precursor

      Status: REVIEWED

      Source sequence(s)
      AC005327, AC090427
      Consensus CDS
      CCDS32933.1
      UniProtKB/TrEMBL
      A0JNV7
      Related
      ENSP00000472735.1, ENST00000594076.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      14724171..14778560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438720.1XP_047294676.1  adhesion G protein-coupled receptor E2 isoform X3

      UniProtKB/TrEMBL
      A0JNV7
    2. XM_047438731.1XP_047294687.1  adhesion G protein-coupled receptor E2 isoform X17

      UniProtKB/TrEMBL
      Q53GP0
    3. XM_047438728.1XP_047294684.1  adhesion G protein-coupled receptor E2 isoform X13

      UniProtKB/TrEMBL
      Q53GP0
    4. XM_047438725.1XP_047294681.1  adhesion G protein-coupled receptor E2 isoform X11

      UniProtKB/TrEMBL
      A0JNV7
    5. XM_047438729.1XP_047294685.1  adhesion G protein-coupled receptor E2 isoform X14

      UniProtKB/TrEMBL
      Q53GP0
    6. XM_047438733.1XP_047294689.1  adhesion G protein-coupled receptor E2 isoform X19

      UniProtKB/TrEMBL
      A0JNV7
    7. XM_047438732.1XP_047294688.1  adhesion G protein-coupled receptor E2 isoform X18

      UniProtKB/TrEMBL
      Q53GP0
    8. XM_047438723.1XP_047294679.1  adhesion G protein-coupled receptor E2 isoform X8

      UniProtKB/TrEMBL
      Q53GP0
    9. XM_047438730.1XP_047294686.1  adhesion G protein-coupled receptor E2 isoform X16

      UniProtKB/TrEMBL
      A0JNV7
    10. XM_047438724.1XP_047294680.1  adhesion G protein-coupled receptor E2 isoform X9

      UniProtKB/TrEMBL
      Q53GP0
    11. XM_047438721.1XP_047294677.1  adhesion G protein-coupled receptor E2 isoform X4

      UniProtKB/TrEMBL
      Q53GP0
      Related
      ENSP00000472280.2, ENST00000596991.6
    12. XM_017026726.2XP_016882215.1  adhesion G protein-coupled receptor E2 isoform X5

      UniProtKB/TrEMBL
      A0JNV7
    13. XM_011527951.4XP_011526253.1  adhesion G protein-coupled receptor E2 isoform X6

      UniProtKB/TrEMBL
      A0JNV7
      Conserved Domains (4) summary
      smart00303
      Location:430480
      GPS; G-protein-coupled receptor proteolytic site domain
      cd00054
      Location:119154
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:163197
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:484725
      7tm_4; Olfactory receptor
    14. XM_011527949.3XP_011526251.1  adhesion G protein-coupled receptor E2 isoform X2

      UniProtKB/TrEMBL
      Q53GP0
      Related
      ENSP00000471297.1, ENST00000601345.5
      Conserved Domains (4) summary
      smart00303
      Location:468518
      GPS; G-protein-coupled receptor proteolytic site domain
      cd00054
      Location:119154
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:163210
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:522763
      7tm_4; Olfactory receptor
    15. XM_011527948.3XP_011526250.1  adhesion G protein-coupled receptor E2 isoform X1

      UniProtKB/TrEMBL
      A0JNV7
      Conserved Domains (4) summary
      smart00303
      Location:479529
      GPS; G-protein-coupled receptor proteolytic site domain
      cd00054
      Location:119154
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:163210
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:533774
      7tm_4; Olfactory receptor
    16. XM_011527953.3XP_011526255.1  adhesion G protein-coupled receptor E2 isoform X10

      UniProtKB/TrEMBL
      A0JNV7
      Related
      ENSP00000469277.1, ENST00000595839.5
      Conserved Domains (3) summary
      smart00303
      Location:386436
      GPS; G-protein-coupled receptor proteolytic site domain
      pfam07645
      Location:119153
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:440681
      7tm_4; Olfactory receptor
    17. XM_017026727.2XP_016882216.1  adhesion G protein-coupled receptor E2 isoform X15

      UniProtKB/TrEMBL
      Q53GP0
    18. XM_047438727.1XP_047294683.1  adhesion G protein-coupled receptor E2 isoform X12

      UniProtKB/TrEMBL
      A0JNV7
    19. XM_011527952.4XP_011526254.1  adhesion G protein-coupled receptor E2 isoform X7

      UniProtKB/TrEMBL
      A0JNV7
      Conserved Domains (3) summary
      cd00054
      Location:119154
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:163210
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:475716
      7tm_4; Olfactory receptor
    20. XM_011527954.4XP_011526256.1  adhesion G protein-coupled receptor E2 isoform X20

      UniProtKB/TrEMBL
      A0JNV7
      Conserved Domains (4) summary
      smart00303
      Location:366416
      GPS; G-protein-coupled receptor proteolytic site domain
      cd00054
      Location:641
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:5097
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:420661
      7tm_4; Olfactory receptor
    21. XM_011527955.3XP_011526257.1  adhesion G protein-coupled receptor E2 isoform X21

      Conserved Domains (3) summary
      smart00303
      Location:280330
      GPS; G-protein-coupled receptor proteolytic site domain
      pfam07645
      Location:1347
      EGF_CA; Calcium-binding EGF domain
      cl21561
      Location:334575
      7tm_4; Olfactory receptor
    22. XM_047438736.1XP_047294692.1  adhesion G protein-coupled receptor E2 isoform X24

      UniProtKB/TrEMBL
      B4DWB8, E9PEL8
      Related
      ENSP00000376689.3, ENST00000392962.3
    23. XM_047438735.1XP_047294691.1  adhesion G protein-coupled receptor E2 isoform X23

    24. XM_047438734.1XP_047294690.1  adhesion G protein-coupled receptor E2 isoform X22

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      14850478..14906112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320779.1XP_054176754.1  adhesion G protein-coupled receptor E2 isoform X26

      UniProtKB/TrEMBL
      A0JNV7
    2. XM_054320793.1XP_054176768.1  adhesion G protein-coupled receptor E2 isoform X17

      UniProtKB/TrEMBL
      Q53GP0
    3. XM_054320783.1XP_054176758.1  adhesion G protein-coupled receptor E2 isoform X28

      UniProtKB/TrEMBL
      A0JNV7
    4. XM_054320787.1XP_054176762.1  adhesion G protein-coupled receptor E2 isoform X29

      UniProtKB/TrEMBL
      A0JNV7
    5. XM_054320778.1XP_054176753.1  adhesion G protein-coupled receptor E2 isoform X25

      UniProtKB/TrEMBL
      A0JNV7
    6. XM_054320780.1XP_054176755.1  adhesion G protein-coupled receptor E2 isoform X27

      UniProtKB/TrEMBL
      A0JNV7
    7. XM_054320789.1XP_054176764.1  adhesion G protein-coupled receptor E2 isoform X13

      UniProtKB/TrEMBL
      Q53GP0
    8. XM_054320790.1XP_054176765.1  adhesion G protein-coupled receptor E2 isoform X14

      UniProtKB/TrEMBL
      Q53GP0
    9. XM_054320795.1XP_054176770.1  adhesion G protein-coupled receptor E2 isoform X19

      UniProtKB/TrEMBL
      A0JNV7
    10. XM_054320794.1XP_054176769.1  adhesion G protein-coupled receptor E2 isoform X18

      UniProtKB/TrEMBL
      Q53GP0
    11. XM_054320784.1XP_054176759.1  adhesion G protein-coupled receptor E2 isoform X8

      UniProtKB/TrEMBL
      Q53GP0
    12. XM_054320792.1XP_054176767.1  adhesion G protein-coupled receptor E2 isoform X16

      UniProtKB/TrEMBL
      A0JNV7
    13. XM_054320785.1XP_054176760.1  adhesion G protein-coupled receptor E2 isoform X9

      UniProtKB/TrEMBL
      A0JNV7
    14. XM_054320786.1XP_054176761.1  adhesion G protein-coupled receptor E2 isoform X10

      UniProtKB/TrEMBL
      A0JNV7
    15. XM_054320781.1XP_054176756.1  adhesion G protein-coupled receptor E2 isoform X5

      UniProtKB/TrEMBL
      A0JNV7
    16. XM_054320777.1XP_054176752.1  adhesion G protein-coupled receptor E2 isoform X2

      UniProtKB/TrEMBL
      Q53GP0
    17. XM_054320797.1XP_054176772.1  adhesion G protein-coupled receptor E2 isoform X21

    18. XM_054320782.1XP_054176757.1  adhesion G protein-coupled receptor E2 isoform X7

      UniProtKB/TrEMBL
      A0JNV7
    19. XM_054320791.1XP_054176766.1  adhesion G protein-coupled receptor E2 isoform X15

      UniProtKB/TrEMBL
      Q53GP0
    20. XM_054320788.1XP_054176763.1  adhesion G protein-coupled receptor E2 isoform X12

      UniProtKB/TrEMBL
      A0JNV7
    21. XM_054320796.1XP_054176771.1  adhesion G protein-coupled receptor E2 isoform X20

      UniProtKB/TrEMBL
      A0JNV7
    22. XM_054320799.1XP_054176774.1  adhesion G protein-coupled receptor E2 isoform X24

    23. XM_054320798.1XP_054176773.1  adhesion G protein-coupled receptor E2 isoform X22

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152918.1: Suppressed sequence

      Description
      NM_152918.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_152919.1: Suppressed sequence

      Description
      NM_152919.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    3. NM_152920.1: Suppressed sequence

      Description
      NM_152920.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    4. NM_152921.1: Suppressed sequence

      Description
      NM_152921.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.