U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from MedGen

    • Showing Current items.

    SLC34A2 solute carrier family 34 member 2 [ Homo sapiens (human) ]

    Gene ID: 10568, updated on 17-Jun-2024

    Summary

    Official Symbol
    SLC34A2provided by HGNC
    Official Full Name
    solute carrier family 34 member 2provided by HGNC
    Primary source
    HGNC:HGNC:11020
    See related
    Ensembl:ENSG00000157765 MIM:604217; AllianceGenome:HGNC:11020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PULAM; NPTIIb; NaPi2b; NAPI-3B; NAPI-IIb
    Summary
    The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]
    Expression
    Restricted expression toward lung (RPKM 380.9) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC34A2 in Genome Data Viewer
    Location:
    4p15.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (25655851..25678748)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (25637821..25660720)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (25657473..25680370)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:25621229-25621730 Neighboring gene S-phase kinase associated protein 1 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr4:25647409-25647582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:25656923-25657836 Neighboring gene ribosomal protein S29 pseudogene 11 Neighboring gene SLIRP. pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ90534

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphate ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sodium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sodium:phosphate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium:phosphate symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sodium:phosphate symporter activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular phosphate ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular phosphate ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphate ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium-dependent phosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in brush border IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in brush border membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in vesicle HDA PubMed 
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    sodium-dependent phosphate transport protein 2B
    Names
    sodium/phosphate cotransporter 2B
    solute carrier family 34 (sodium phosphate), member 2
    solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
    type II sodium-dependent phosphate transporter 3b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021185.2 RefSeqGene

      Range
      5002..27899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001177998.2NP_001171469.2  sodium-dependent phosphate transport protein 2B isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC092436
      Consensus CDS
      CCDS54750.1
      UniProtKB/TrEMBL
      A8K9G0
      Related
      ENSP00000425501.1, ENST00000504570.5
      Conserved Domains (1) summary
      TIGR01013
      Location:104603
      2a58; Phosphate:Na+ Symporter (PNaS) Family
    2. NM_001177999.2NP_001171470.2  sodium-dependent phosphate transport protein 2B isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC092436
      Consensus CDS
      CCDS54750.1
      UniProtKB/TrEMBL
      A8K9G0
      Related
      ENSP00000423021.1, ENST00000503434.5
      Conserved Domains (1) summary
      TIGR01013
      Location:104603
      2a58; Phosphate:Na+ Symporter (PNaS) Family
    3. NM_006424.3NP_006415.3  sodium-dependent phosphate transport protein 2B isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC092436
      Consensus CDS
      CCDS3435.1
      UniProtKB/Swiss-Prot
      A5PL17, O95436, Q8N2K2, Q8WYA9, Q9P0V7
      UniProtKB/TrEMBL
      A0A0B5E3E9
      Related
      ENSP00000371483.3, ENST00000382051.8
      Conserved Domains (1) summary
      TIGR01013
      Location:105604
      2a58; Phosphate:Na+ Symporter (PNaS) Family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      25655851..25678748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      25637821..25660720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)