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    RPS6KA3 ribosomal protein S6 kinase A3 [ Homo sapiens (human) ]

    Gene ID: 6197, updated on 3-Apr-2024

    Summary

    Official Symbol
    RPS6KA3provided by HGNC
    Official Full Name
    ribosomal protein S6 kinase A3provided by HGNC
    Primary source
    HGNC:HGNC:10432
    See related
    Ensembl:ENSG00000177189 MIM:300075; AllianceGenome:HGNC:10432
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; XLID19; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3
    Summary
    This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in appendix (RPKM 16.2), colon (RPKM 16.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RPS6KA3 in Genome Data Viewer
    Location:
    Xp22.12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (20149911..20267097, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (19732804..19849991, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (20168029..20285027, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29480 Neighboring gene EIF1AX antisense RNA 1 Neighboring gene small Cajal body-specific RNA 9 like Neighboring gene eukaryotic translation initiation factor 1A X-linked Neighboring gene Sharpr-MPRA regulatory region 15471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20697 Neighboring gene Sharpr-MPRA regulatory region 100 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29484 Neighboring gene RN7SK pseudogene 183 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:20504565-20505764 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:20532054-20533253 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20698 Neighboring gene uncharacterized LOC124905257

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2022-06-14)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2022-06-14)

    ClinGen Genome Curation PagePubMed

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of ribosomal protein S6 kinase, polypeptide 3 (RPS6KA3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat RSK2 is selectively involved in LTR stimulation by the HIV-1 Tat protein, but constitutively active RSK2 is unable to stimulate the LTR PubMed
    tat Interaction of HIV-1 Tat with p90 ribosomal S6 kinase 2 (RSK2) is observed in vivo and in vitro. The critical interacting residues lie within amino acids 36-39 in Tat and 1-360 in RSK2. RSK2 supports HIV-1 Tat transactivation via binding to F38 PubMed
    tat Activation of the N-terminal RSK2 kinase activity is enhanced by HIV-1 Tat in a dose-dependent manner. PubMed
    tat Phosphorylation of serine 227 in RSK2 is increased by Tat; mutation at position F38 abolishes the Tat-mediated phosphorylation of RSK2. PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables ribosomal protein S6 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in chemical synaptic transmission TAS
    Traceable Author Statement
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-serine phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cell growth TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of translation in response to stress TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in skeletal system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ribosomal protein S6 kinase alpha-3
    Names
    MAP kinase-activated protein kinase 1b
    MAPK-activated protein kinase 1b
    MAPKAP kinase 1b
    MAPKAPK-1b
    RSK-2
    S6K-alpha-3
    epididymis secretory sperm binding protein
    insulin-stimulated protein kinase 1
    p90-RSK 3
    ribosomal S6 kinase 2
    ribosomal protein S6 kinase, 90kDa, polypeptide 3
    NP_004577.1
    XP_005274630.1
    XP_005274634.1
    XP_011543857.1
    XP_011543858.1
    XP_011543859.1
    XP_011543862.1
    XP_011543863.1
    XP_011543864.1
    XP_016885206.1
    XP_016885207.1
    XP_016885208.1
    XP_047298288.1
    XP_047298289.1
    XP_047298290.1
    XP_047298291.1
    XP_047298292.1
    XP_054183497.1
    XP_054183498.1
    XP_054183499.1
    XP_054183500.1
    XP_054183501.1
    XP_054183502.1
    XP_054183503.1
    XP_054183504.1
    XP_054183505.1
    XP_054183506.1
    XP_054183507.1
    XP_054183508.1
    XP_054183509.1
    XP_054183510.1
    XP_054183511.1
    XP_054183512.1
    XP_054183513.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007488.1 RefSeqGene

      Range
      4724..121722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004586.3NP_004577.1  ribosomal protein S6 kinase alpha-3

      See identical proteins and their annotated locations for NP_004577.1

      Status: REVIEWED

      Source sequence(s)
      AA317826, AA858312, AB102662, AK022869, AL732366, AL807772, AV684171, BC015451, BQ427696, BU618685, CA843287, CA843526, CK905714, U08316, W00439
      Consensus CDS
      CCDS14197.1
      UniProtKB/Swiss-Prot
      B2R9V4, P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7
      UniProtKB/TrEMBL
      A0A384MDW3, B4DKZ2
      Related
      ENSP00000368884.3, ENST00000379565.9
      Conserved Domains (2) summary
      cd05582
      Location:72388
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:402740
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      20149911..20267097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545561.3XP_011543863.1  ribosomal protein S6 kinase alpha-3 isoform X6

      See identical proteins and their annotated locations for XP_011543863.1

      UniProtKB/TrEMBL
      B4DKZ2
      Conserved Domains (4) summary
      smart00220
      Location:40305
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:44366
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:380718
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:400657
      Pkinase; Protein kinase domain
    2. XM_017029719.3XP_016885208.1  ribosomal protein S6 kinase alpha-3 isoform X11

      UniProtKB/TrEMBL
      B4DG22, B4DKZ2
      Related
      ENSP00000495974.1, ENST00000644893.1
      Conserved Domains (2) summary
      cd05582
      Location:44360
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:374711
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    3. XM_047442335.1XP_047298291.1  ribosomal protein S6 kinase alpha-3 isoform X9

      Conserved Domains (2) summary
      cd05582
      Location:44360
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:374703
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    4. XM_017029717.3XP_016885206.1  ribosomal protein S6 kinase alpha-3 isoform X8

      UniProtKB/TrEMBL
      B4DKZ2, B7ZB17
      Related
      ENSP00000495462.1, ENST00000646610.1
      Conserved Domains (2) summary
      cd05582
      Location:44360
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:374712
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    5. XM_047442333.1XP_047298289.1  ribosomal protein S6 kinase alpha-3 isoform X5

    6. XM_005274573.3XP_005274630.1  ribosomal protein S6 kinase alpha-3 isoform X4

      See identical proteins and their annotated locations for XP_005274630.1

      UniProtKB/TrEMBL
      B4DKZ2
      Conserved Domains (2) summary
      cd05582
      Location:72388
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:402739
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    7. XM_047442332.1XP_047298288.1  ribosomal protein S6 kinase alpha-3 isoform X3

    8. XM_011545556.2XP_011543858.1  ribosomal protein S6 kinase alpha-3 isoform X2

      UniProtKB/TrEMBL
      B4DKZ2
      Conserved Domains (4) summary
      smart00220
      Location:68333
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:72394
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:408745
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:427684
      Pkinase; Protein kinase domain
    9. XM_011545555.2XP_011543857.1  ribosomal protein S6 kinase alpha-3 isoform X1

      UniProtKB/TrEMBL
      B4DKZ2
      Conserved Domains (4) summary
      smart00220
      Location:68333
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:72394
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:408737
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:428685
      Pkinase; Protein kinase domain
    10. XM_047442336.1XP_047298292.1  ribosomal protein S6 kinase alpha-3 isoform X11

      UniProtKB/TrEMBL
      B4DG22
    11. XM_047442334.1XP_047298290.1  ribosomal protein S6 kinase alpha-3 isoform X8

      UniProtKB/TrEMBL
      B7ZB17
      Related
      ENSP00000496271.1, ENST00000643085.1
    12. XM_011545560.2XP_011543862.1  ribosomal protein S6 kinase alpha-3 isoform X6

      See identical proteins and their annotated locations for XP_011543862.1

      UniProtKB/TrEMBL
      B4DKZ2
      Conserved Domains (4) summary
      smart00220
      Location:40305
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:44366
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:380718
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:400657
      Pkinase; Protein kinase domain
    13. XM_011545557.3XP_011543859.1  ribosomal protein S6 kinase alpha-3 isoform X6

      See identical proteins and their annotated locations for XP_011543859.1

      UniProtKB/TrEMBL
      B4DKZ2
      Conserved Domains (4) summary
      smart00220
      Location:40305
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:44366
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:380718
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:400657
      Pkinase; Protein kinase domain
    14. XM_005274577.4XP_005274634.1  ribosomal protein S6 kinase alpha-3 isoform X12

      See identical proteins and their annotated locations for XP_005274634.1

      UniProtKB/TrEMBL
      B4DKZ2
      Conserved Domains (2) summary
      cd05582
      Location:43359
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:373710
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    15. XM_017029718.3XP_016885207.1  ribosomal protein S6 kinase alpha-3 isoform X10

      UniProtKB/TrEMBL
      B1AXG1, B4DKZ2
      Related
      ENSP00000407655.2, ENST00000457145.6
      Conserved Domains (2) summary
      cd05582
      Location:43359
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:373711
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    16. XM_011545562.3XP_011543864.1  ribosomal protein S6 kinase alpha-3 isoform X7

      UniProtKB/TrEMBL
      B4DKZ2
      Conserved Domains (4) summary
      smart00220
      Location:39304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:43365
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:379717
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:399656
      Pkinase; Protein kinase domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      19732804..19849991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327529.1XP_054183504.1  ribosomal protein S6 kinase alpha-3 isoform X6

    2. XM_054327536.1XP_054183511.1  ribosomal protein S6 kinase alpha-3 isoform X11

      UniProtKB/TrEMBL
      B4DG22
    3. XM_054327533.1XP_054183508.1  ribosomal protein S6 kinase alpha-3 isoform X9

    4. XM_054327531.1XP_054183506.1  ribosomal protein S6 kinase alpha-3 isoform X8

      UniProtKB/TrEMBL
      B7ZB17
    5. XM_054327526.1XP_054183501.1  ribosomal protein S6 kinase alpha-3 isoform X5

    6. XM_054327525.1XP_054183500.1  ribosomal protein S6 kinase alpha-3 isoform X4

    7. XM_054327524.1XP_054183499.1  ribosomal protein S6 kinase alpha-3 isoform X3

    8. XM_054327523.1XP_054183498.1  ribosomal protein S6 kinase alpha-3 isoform X2

    9. XM_054327522.1XP_054183497.1  ribosomal protein S6 kinase alpha-3 isoform X1

    10. XM_054327537.1XP_054183512.1  ribosomal protein S6 kinase alpha-3 isoform X11

      UniProtKB/TrEMBL
      B4DG22
    11. XM_054327534.1XP_054183509.1  ribosomal protein S6 kinase alpha-3 isoform X8

      UniProtKB/TrEMBL
      B7ZB17
    12. XM_054327528.1XP_054183503.1  ribosomal protein S6 kinase alpha-3 isoform X6

    13. XM_054327527.1XP_054183502.1  ribosomal protein S6 kinase alpha-3 isoform X6

    14. XM_054327532.1XP_054183507.1  ribosomal protein S6 kinase alpha-3 isoform X8

      UniProtKB/TrEMBL
      B7ZB17
    15. XM_054327538.1XP_054183513.1  ribosomal protein S6 kinase alpha-3 isoform X12

    16. XM_054327535.1XP_054183510.1  ribosomal protein S6 kinase alpha-3 isoform X10

      UniProtKB/TrEMBL
      B1AXG1
    17. XM_054327530.1XP_054183505.1  ribosomal protein S6 kinase alpha-3 isoform X7