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    MAT1A methionine adenosyltransferase 1A [ Homo sapiens (human) ]

    Gene ID: 4143, updated on 26-Feb-2024

    Summary

    Official Symbol
    MAT1Aprovided by HGNC
    Official Full Name
    methionine adenosyltransferase 1Aprovided by HGNC
    Primary source
    HGNC:HGNC:6903
    See related
    Ensembl:ENSG00000151224 MIM:610550; AllianceGenome:HGNC:6903
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAT; SAMS; MATA1; SAMS1
    Summary
    This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward liver (RPKM 313.0) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MAT1A in Genome Data Viewer
    Location:
    10q22.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (80271820..80289658, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (81140919..81158757, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (82031576..82049414, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3652 Neighboring gene uncharacterized LOC100130698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3653 Neighboring gene eukaryotic translation initiation factor 5A pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:82016108-82016608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:82016609-82017109 Neighboring gene Sharpr-MPRA regulatory region 3184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:82024050-82024581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:82024582-82025112 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:82032694-82033893 Neighboring gene Sharpr-MPRA regulatory region 13640 Neighboring gene zinc finger protein 519 pseudogene 1 Neighboring gene MPRA-validated peak1026 silencer Neighboring gene DPY30 domain containing 1 Neighboring gene DPY30 domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methionine adenosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methionine adenosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of methionine adenosyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of methionine adenosyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    S-adenosylmethionine synthase isoform type-1
    Names
    MAT 1
    MAT-I/III
    adoMet synthase 1
    adoMet synthetase 1
    methionine adenosyltransferase 1
    methionine adenosyltransferase I, alpha
    methionine adenosyltransferase I/III
    NP_000420.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008083.1 RefSeqGene

      Range
      5021..22859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000429.3NP_000420.1  S-adenosylmethionine synthase isoform type-1

      See identical proteins and their annotated locations for NP_000420.1

      Status: REVIEWED

      Source sequence(s)
      BC018359, BM738684, BX496326, X69078
      Consensus CDS
      CCDS7365.1
      UniProtKB/Swiss-Prot
      D3DWD5, Q00266, Q5QP09
      UniProtKB/TrEMBL
      A8K455
      Related
      ENSP00000361287.3, ENST00000372213.8
      Conserved Domains (1) summary
      PTZ00104
      Location:12393
      PTZ00104; S-adenosylmethionine synthase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      80271820..80289658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      81140919..81158757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)