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    ADAR adenosine deaminase RNA specific [ Homo sapiens (human) ]

    Gene ID: 103, updated on 17-Jun-2024

    Summary

    Official Symbol
    ADARprovided by HGNC
    Official Full Name
    adenosine deaminase RNA specificprovided by HGNC
    Primary source
    HGNC:HGNC:225
    See related
    Ensembl:ENSG00000160710 MIM:146920; AllianceGenome:HGNC:225
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DSH; AGS6; G1P1; IFI4; P136; ADAR1; DRADA; DSRAD; IFI-4; K88DSRBP
    Summary
    This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
    Expression
    Ubiquitous expression in spleen (RPKM 49.6), appendix (RPKM 40.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADAR in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (154582057..154627997, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (153719177..153765142, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154554533..154600473, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1363 Neighboring gene Sharpr-MPRA regulatory region 5811 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:154561176-154562375 Neighboring gene cholinergic receptor nicotinic beta 2 subunit Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1780 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154581605-154582598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1781 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154599559-154600344 Neighboring gene uncharacterized LOC124904427 Neighboring gene uncharacterized LOC124904428 Neighboring gene uncharacterized LOC124904429 Neighboring gene potassium calcium-activated channel subfamily N member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Aicardi-Goutieres syndrome 6
    MedGen: C3539013 OMIM: 615010 GeneReviews: Aicardi-Goutieres Syndrome
    Compare labs
    Symmetrical dyschromatosis of extremities
    MedGen: C0406775 OMIM: 127400 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
    EBI GWAS Catalog
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (overnight) induces 150-kDa ADAR protein expression in primary human monocyte-derived macrophages BUT NOT in primary CD4+ T cells PubMed
    HIV-1 requires ADAR1 for efficient replication in CD4+ T cells as shown through knockdown and genetic deletion PubMed
    shRNA knockdown of ADAR increases HIV-1 RNA copies in OM10.1 cells (latently infected with HIV-1); HIV is restricted by ADAR PubMed
    HIV-1 is restricted by ADAR in OM10.1 cells (latently infected with HIV-1) overexpressing 150-kDa ADAR PubMed
    siRNA knockdown of ADAR increases HIV-1 replication in monocyte-derived macrophages and alveolar macrophages from HIV-infected patients on antiretroviral therapy (N=4); ADAR restricts HIV-1 replication PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify adenosine deaminase RNA-specific binding protein (ADAR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    env ADAR1 inhibits HIV-1 viral protein synthesis such as p24 CA, gp120, and p65 Pol proteins in the various cell lines. The catalytic motif of ADAR1 deaminase domain is required for the inhibition function PubMed
    env Overexpression of ADAR1 increases the levels of gp120, p24, and Nef in HIV-1 producer cells, which requires inhibition of the RNA-activated protein kinase PKR PubMed
    env HIV-1 gp120 inhibits adenosine deaminase (ADA) binding to CD26 (dipeptidyl-peptidase 4) in both CD4+ and CD4- cells; this effect requires the interaction of gp120 with CD4 or CXCR4 PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify adenosine deaminase RNA-specific binding protein (ADAR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify adenosine deaminase RNA-specific binding protein (ADAR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    nef Overexpression of ADAR1 increases the levels of gp120, p24, and Nef in HIV-1 producer cells, which requires inhibition of the RNA-activated protein kinase PKR PubMed
    Pr55(Gag) gag p55 Gag associates with ADAR1 PubMed
    gag Tandem affinity purification and mass spectrometry analysis identify adenosine deaminase RNA-specific binding protein (ADAR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, adenosine deaminase, RNA-specific (ADAR), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with ADAR is increased by RRE PubMed
    rev ADAR1-mediated A-to-G mutations in RRE region of the env gene affect the binding of HIV-1 Rev PubMed
    Tat tat Expression of HIV-1 Tat downregulates the abundance of RNA-specific adenosine deaminase (ADAR) in the nucleoli of Jurkat T-cells PubMed
    capsid gag ADAR1 inhibits HIV-1 viral protein synthesis such as p24 CA, gp120, and p65 Pol proteins in the various cell lines. The catalytic motif of ADAR1 deaminase domain is required for the inhibition function PubMed
    gag Overexpression of ADAR1 increases the levels of gp120, p24, and Nef in HIV-1 producer cells, which requires inhibition of the RNA-activated protein kinase PKR PubMed
    reverse transcriptase gag-pol ADAR1 inhibits HIV-1 viral protein synthesis such as p24 CA, gp120, and p65 Pol proteins in the various cell lines. The catalytic motif of ADAR1 deaminase domain is required for the inhibition function PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables double-stranded RNA adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded RNA adenosine deaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded RNA adenosine deaminase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tRNA-specific adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within RISC complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenosine to inosine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenosine to inosine editing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenosine to inosine editing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within base conversion or substitution editing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in definitive hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hematopoietic stem cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hepatocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of hepatocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of post-transcriptional gene silencing by regulatory ncRNA IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of type I interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within pre-miRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to interferon-alpha IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in somatic diversification of immune receptors via somatic mutation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of supraspliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    double-stranded RNA-specific adenosine deaminase
    Names
    136 kDa double-stranded RNA-binding protein
    adenosine deaminase acting on RNA 1-A
    dsRNA adenosine deaminase
    dsRNA adeonosine deaminase
    interferon-induced protein 4
    interferon-inducible protein 4
    NP_001020278.1
    NP_001102.3
    NP_001180424.1
    NP_001351974.1
    NP_001351975.1
    NP_001351976.1
    NP_001351977.1
    NP_001351978.1
    NP_056655.3
    NP_056656.3
    XP_011507363.2
    XP_011507364.1
    XP_047284296.1
    XP_047284342.1
    XP_047284361.1
    XP_047284397.1
    XP_054189776.1
    XP_054189777.1
    XP_054189778.1
    XP_054189779.1
    XP_054189780.1
    XP_054189781.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011844.2 RefSeqGene

      Range
      28375..54504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1212

    mRNA and Protein(s)

    1. NM_001025107.3NP_001020278.1  double-stranded RNA-specific adenosine deaminase isoform d

      See identical proteins and their annotated locations for NP_001020278.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (d) is shorter at the N-terminus, compared to isoform a. Variants 4, 5, 7, 8, and 9, encode the same isoform.
      Source sequence(s)
      AA449679, AL592078, AL606500, BX538232, BX640741, CD108625
      Consensus CDS
      CCDS30879.1
      UniProtKB/TrEMBL
      A0A7P0Z4F9
      Related
      ENSP00000357456.3, ENST00000368471.8
      Conserved Domains (5) summary
      smart00552
      Location:544927
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
      cd19913
      Location:207277
      DSRM_DRADA_rpt1; first double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA)
      cd19914
      Location:318388
      DSRM_DRADA_rpt2; second double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
      cd19915
      Location:430500
      DSRM_DRADA_rpt3; third double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
    2. NM_001111.5NP_001102.3  double-stranded RNA-specific adenosine deaminase isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (a, also referred to as ADAR-a).
      Source sequence(s)
      AA449679, AI309328, AK304153, AL592078, AL606500, U10439
      Consensus CDS
      CCDS1071.1
      UniProtKB/Swiss-Prot
      B1AQQ9, B1AQR0, D3DV76, O15223, O43859, O43860, P55265, Q9BYM3, Q9BYM4
      UniProtKB/TrEMBL
      A0A024DAK3
      Related
      ENSP00000357459.4, ENST00000368474.9
      Conserved Domains (3) summary
      smart00358
      Location:504569
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:8391222
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:135201
      z-alpha; Adenosine deaminase z-alpha domain
    3. NM_001193495.2NP_001180424.1  double-stranded RNA-specific adenosine deaminase isoform d

      See identical proteins and their annotated locations for NP_001180424.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (d) is shorter at the N-terminus, compared to isoform a. Variants 4, 5, 7, 8, and 9, encode the same isoform.
      Source sequence(s)
      AA449679, AL592078, AL606500, CD108625, X79448
      Consensus CDS
      CCDS30879.1
      UniProtKB/TrEMBL
      A0A7P0Z4F9
      Related
      ENSP00000497555.1, ENST00000648231.2
      Conserved Domains (5) summary
      smart00552
      Location:544927
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
      cd19913
      Location:207277
      DSRM_DRADA_rpt1; first double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA)
      cd19914
      Location:318388
      DSRM_DRADA_rpt2; second double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
      cd19915
      Location:430500
      DSRM_DRADA_rpt3; third double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
    4. NM_001365045.1NP_001351974.1  double-stranded RNA-specific adenosine deaminase isoform e

      Status: REVIEWED

      Source sequence(s)
      AL592078, AL606500, AL691488
      UniProtKB/TrEMBL
      A0A024DAK3
      Related
      ENSP00000497932.2, ENST00000649724.2
      Conserved Domains (3) summary
      smart00358
      Location:513578
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:8481231
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:144210
      z-alpha; Adenosine deaminase z-alpha domain
    5. NM_001365046.1NP_001351975.1  double-stranded RNA-specific adenosine deaminase isoform d

      Status: REVIEWED

      Description
      Transcript Variant: Variants 4, 5, 7, 8, and 9, encode the same isoform.
      Source sequence(s)
      AL592078, AL606500, AL691488
      Consensus CDS
      CCDS30879.1
      UniProtKB/TrEMBL
      A0A7P0Z4F9
      Related
      ENSP00000506666.1, ENST00000681683.1
      Conserved Domains (5) summary
      smart00552
      Location:544927
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
      cd19913
      Location:207277
      DSRM_DRADA_rpt1; first double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA)
      cd19914
      Location:318388
      DSRM_DRADA_rpt2; second double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
      cd19915
      Location:430500
      DSRM_DRADA_rpt3; third double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
    6. NM_001365047.1NP_001351976.1  double-stranded RNA-specific adenosine deaminase isoform d

      Status: REVIEWED

      Description
      Transcript Variant: Variants 4, 5, 7, 8, and 9, encode the same isoform.
      Source sequence(s)
      AL592078, AL606500, AL691488
      Consensus CDS
      CCDS30879.1
      UniProtKB/TrEMBL
      A0A7P0Z4F9
      Conserved Domains (5) summary
      smart00552
      Location:544927
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
      cd19913
      Location:207277
      DSRM_DRADA_rpt1; first double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA)
      cd19914
      Location:318388
      DSRM_DRADA_rpt2; second double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
      cd19915
      Location:430500
      DSRM_DRADA_rpt3; third double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
    7. NM_001365048.1NP_001351977.1  double-stranded RNA-specific adenosine deaminase isoform d

      Status: REVIEWED

      Description
      Transcript Variant: Variants 4, 5, 7, 8, and 9, encode the same isoform.
      Source sequence(s)
      AL592078, AL606500, AL691488
      Consensus CDS
      CCDS30879.1
      UniProtKB/TrEMBL
      A0A7P0Z4F9
      Related
      ENSP00000497210.1, ENST00000649749.1
      Conserved Domains (5) summary
      smart00552
      Location:544927
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
      cd19913
      Location:207277
      DSRM_DRADA_rpt1; first double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA)
      cd19914
      Location:318388
      DSRM_DRADA_rpt2; second double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
      cd19915
      Location:430500
      DSRM_DRADA_rpt3; third double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
    8. NM_001365049.1NP_001351978.1  double-stranded RNA-specific adenosine deaminase isoform f

      Status: REVIEWED

      Source sequence(s)
      AL592078, AL606500, AL691488
      UniProtKB/TrEMBL
      A0A7P0Z4F9
      Related
      ENSP00000518934.1, ENST00000526905.3
      Conserved Domains (3) summary
      smart00358
      Location:209274
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:518901
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
    9. NM_015840.4NP_056655.3  double-stranded RNA-specific adenosine deaminase isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b, also referred to as ADAR-b) that is shorter than isoform a. There are no publicly available full-length transcripts representing this variant; it is represented based on data in PMID:9020165 and annotation on DNA accession U75503.1.
      Source sequence(s)
      AA449679, AL592078, AL606500, CD108625, U10439
      Consensus CDS
      CCDS44231.1
      UniProtKB/TrEMBL
      A0A024DAK3
      Related
      ENSP00000431794.2, ENST00000529168.2
      Conserved Domains (3) summary
      smart00358
      Location:504569
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:8131196
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:135201
      z-alpha; Adenosine deaminase z-alpha domain
    10. NM_015841.4NP_056656.3  double-stranded RNA-specific adenosine deaminase isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the central coding region, compared to variant 1, resulting in an isoform (c, also referred to as ADAR-c) that is shorter than isoform a. There are no publicly available full-length transcripts representing this variant; it is represented based on data in PMID:9020165 and annotation on DNA accession U75503.1.
      Source sequence(s)
      AA449679, AL592078, AL606500, CD108625, U10439
      UniProtKB/TrEMBL
      A0A3B3IRQ9
      Conserved Domains (3) summary
      smart00358
      Location:504569
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:7941177
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:135201
      z-alpha; Adenosine deaminase z-alpha domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      154582057..154627997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428340.1XP_047284296.1  double-stranded RNA-specific adenosine deaminase isoform X3

      UniProtKB/TrEMBL
      A0A024DAK3
    2. XM_011509061.3XP_011507363.2  double-stranded RNA-specific adenosine deaminase isoform X1

      UniProtKB/TrEMBL
      A0A7P0Z4F9
      Related
      ENSP00000518929.1, ENST00000713631.1
      Conserved Domains (3) summary
      smart00358
      Location:209274
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:518901
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
    3. XM_011509062.2XP_011507364.1  double-stranded RNA-specific adenosine deaminase isoform X2

      UniProtKB/TrEMBL
      A0A024DAK3
      Conserved Domains (3) summary
      smart00358
      Location:510575
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:8451228
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:141207
      z-alpha; Adenosine deaminase z-alpha domain
    4. XM_047428386.1XP_047284342.1  double-stranded RNA-specific adenosine deaminase isoform X4

      UniProtKB/TrEMBL
      A0A024DAK3
    5. XM_047428441.1XP_047284397.1  double-stranded RNA-specific adenosine deaminase isoform X6

      UniProtKB/TrEMBL
      A0A3B3IRQ9
    6. XM_047428405.1XP_047284361.1  double-stranded RNA-specific adenosine deaminase isoform X5

      UniProtKB/TrEMBL
      A0A024DAK3
      Related
      ENST00000647682.2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      153719177..153765142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333803.1XP_054189778.1  double-stranded RNA-specific adenosine deaminase isoform X3

      UniProtKB/TrEMBL
      A0A024DAK3
    2. XM_054333801.1XP_054189776.1  double-stranded RNA-specific adenosine deaminase isoform X1

      UniProtKB/TrEMBL
      A0A7P0Z4F9
    3. XM_054333802.1XP_054189777.1  double-stranded RNA-specific adenosine deaminase isoform X2

      UniProtKB/TrEMBL
      A0A024DAK3
    4. XM_054333804.1XP_054189779.1  double-stranded RNA-specific adenosine deaminase isoform X4

      UniProtKB/TrEMBL
      A0A024DAK3
    5. XM_054333806.1XP_054189781.1  double-stranded RNA-specific adenosine deaminase isoform X6

      UniProtKB/TrEMBL
      A0A3B3IRQ9
    6. XM_054333805.1XP_054189780.1  double-stranded RNA-specific adenosine deaminase isoform X5

      UniProtKB/TrEMBL
      A0A024DAK3