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    PROK2 prokineticin 2 [ Homo sapiens (human) ]

    Gene ID: 60675, updated on 23-Nov-2023

    Summary

    Official Symbol
    PROK2provided by HGNC
    Official Full Name
    prokineticin 2provided by HGNC
    Primary source
    HGNC:HGNC:18455
    See related
    Ensembl:ENSG00000163421 MIM:607002; AllianceGenome:HGNC:18455
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BV8; HH4; PK2; KAL4; MIT1
    Summary
    This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in bone marrow (RPKM 18.5), appendix (RPKM 9.5) and 4 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PROK2 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (71771655..71785148, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (71810890..71824379, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (71820806..71834299, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377155 Neighboring gene NANOG hESC enhancer GRCh37_chr3:71694238-71694747 Neighboring gene eukaryotic translation initiation factor 4E family member 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:71752927-71753508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14522 Neighboring gene Sharpr-MPRA regulatory region 3624 Neighboring gene G protein-coupled receptor 27 Neighboring gene uncharacterized LOC105377156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:71864572-71865144 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:71865145-71865717 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:71866364-71867052 Neighboring gene RNA, 7SL, cytoplasmic 271, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif upregulates the expression of prokineticin 2 (PROK2) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    prokineticin-2
    Names
    protein Bv8 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008275.1 RefSeqGene

      Range
      5059..18552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001126128.2NP_001119600.1  prokineticin-2 isoform a precursor

      See identical proteins and their annotated locations for NP_001119600.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC096970, BC098162
      Consensus CDS
      CCDS46868.1
      UniProtKB/Swiss-Prot
      Q53Z79, Q6ISR0, Q9HC23
      Related
      ENSP00000295619.3, ENST00000295619.4
      Conserved Domains (1) summary
      pfam06607
      Location:23126
      Prokineticin; Prokineticin
    2. NM_021935.4NP_068754.1  prokineticin-2 isoform b precursor

      See identical proteins and their annotated locations for NP_068754.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AC096970, BC069395
      Consensus CDS
      CCDS2916.1
      UniProtKB/Swiss-Prot
      Q9HC23
      Related
      ENSP00000295618.3, ENST00000353065.7
      Conserved Domains (1) summary
      pfam06607
      Location:23105
      Prokineticin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      71771655..71785148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      71810890..71824379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)