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    CAMTA1 calmodulin binding transcription activator 1 [ Homo sapiens (human) ]

    Gene ID: 23261, updated on 12-Feb-2024

    Summary

    Official Symbol
    CAMTA1provided by HGNC
    Official Full Name
    calmodulin binding transcription activator 1provided by HGNC
    Primary source
    HGNC:HGNC:18806
    See related
    Ensembl:ENSG00000171735 MIM:611501; AllianceGenome:HGNC:18806
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CECBA; CANPMR
    Summary
    The protein encoded by this gene contains a CG1 DNA-binding domain, a transcription factor immunoglobulin domain, ankyrin repeats, and calmodulin-binding IQ motifs. The encoded protein is thought to be a transcription factor and may be a tumor suppressor. However, a translocation event is sometimes observed between this gene and the WWTR1 gene, with the resulting WWTR1-CAMTA1 oncoprotein leading to epithelioid hemangioendothelioma, a malignant vascular cancer. [provided by RefSeq, Mar 2017]
    Expression
    Ubiquitous expression in brain (RPKM 5.0), adrenal (RPKM 1.5) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CAMTA1 in Genome Data Viewer
    Location:
    1p36.31-p36.23
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (6785454..7769706)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (6313294..7300752)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6845514..7829766)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:6843880-6844556 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:6844557-6845231 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 179 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6868944-6869444 Neighboring gene uncharacterized LOC124903832 Neighboring gene CAMTA1 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6927405-6928137 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6967713-6968438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6969150-6969650 Neighboring gene ribosomal protein L37 pseudogene 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6969651-6970151 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6990406-6990906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7011017-7011720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7016017-7016546 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:7016547-7017077 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:7017078-7017607 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7029419-7029919 Neighboring gene MPRA-validated peak33 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7039565-7040410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 183 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:7086000-7087199 Neighboring gene CAMTA1 antisense RNA 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7109791-7110690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 89 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:7142559-7142729 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:7153467-7153661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7209665-7210272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7234210-7234710 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:7237955-7238455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7284388-7284888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7284889-7285389 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7305529-7306030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7344591-7345092 Neighboring gene RNA, U1 small nuclear 8, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7354235-7354752 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7377679-7378878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7395955-7396832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7433523-7434023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7438503-7439129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7439130-7439755 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7439756-7440382 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7440383-7441007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7448189-7448726 Neighboring gene CAMTA1 intronic transcript 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:7461491-7462690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7463312-7463812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7469057-7469988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7469989-7470920 Neighboring gene CAMTA1 antisense RNA 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:7491149-7491650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7517439-7518106 Neighboring gene CAMTA1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7530650-7531194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7532917-7533608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7551761-7552396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7560506-7561006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7561007-7561507 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7562099-7562599 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7565577-7566214 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7563935-7564790 Neighboring gene uncharacterized LOC105376691 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7563077-7563934 Neighboring gene MPRA-validated peak35 silencer Neighboring gene MPRA-validated peak36 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7594027-7595006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7598278-7598983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7643497-7643996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7646449-7647169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7655704-7656204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7668502-7669038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7669039-7669576 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7669577-7670113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7670114-7670651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7672975-7673506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7673507-7674037 Neighboring gene MPRA-validated peak37 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7685250-7685750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7695174-7696155 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7700515-7701015 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7702117-7703085 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7703871-7704371 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7710763-7711264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7711265-7711764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7717029-7717568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7723269-7723770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 90 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7729239-7730085 Neighboring gene translation initiation factor IF-2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 185 Neighboring gene MPRA-validated peak40 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7798026-7799225 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:7830560-7831256 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:7831283-7831525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 187 Neighboring gene uncharacterized LOC124903833 Neighboring gene MPRA-validated peak42 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7886590-7887789 Neighboring gene vesicle associated membrane protein 3 Neighboring gene period circadian regulator 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Cerebellar dysfunction with variable cognitive and behavioral abnormalities
    MedGen: C3553661 OMIM: 614756 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2017-12-14)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2017-12-14)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD.
    EBI GWAS Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
    EBI GWAS Catalog
    Genome-wide association study of periodontal pathogen colonization.
    EBI GWAS Catalog
    Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0833

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    calmodulin-binding transcription activator 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053148.1 RefSeqGene

      Range
      5131..989383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001195563.2NP_001182492.1  calmodulin-binding transcription activator 1 isoform b

      See identical proteins and their annotated locations for NP_001182492.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate, 3' terminal exon compared to variant 1. This results in a much shorter protein (isoform b, also known as 2) that lacks the ankyrin repeats and calmodulin-binding motifs, compared to isoform a.
      Source sequence(s)
      AB020640, BC116457
      Consensus CDS
      CCDS55574.1
      UniProtKB/TrEMBL
      H0YJV1
      Related
      ENSP00000451388.1, ENST00000473578.5
    2. NM_001242701.2NP_001229630.1  calmodulin-binding transcription activator 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate, 3' terminal exon compared to variant 1. This results in a shorter protein (isoform c, also known as 3) that lacks the ankyrin repeats and calmodulin-binding motifs, compared to isoform a.
      Source sequence(s)
      AI278074, BC151835, CD103791
      Consensus CDS
      CCDS55575.1
      UniProtKB/Swiss-Prot
      Q9Y6Y1
      Related
      ENSP00000451510.1, ENST00000557126.5
    3. NM_001349608.2NP_001336537.1  calmodulin-binding transcription activator 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) encodes isoform d.
      Source sequence(s)
      AL359881, AL365194, AL590128, AL596210, KF495855, Z97635, Z98052, Z98884
      Conserved Domains (4) summary
      smart01076
      Location:37153
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      cd00204
      Location:10351156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:10341077
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:843922
      TIG; IPT/TIG domain
    4. NM_001349609.2NP_001336538.1  calmodulin-binding transcription activator 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) encodes isoform e.
      Source sequence(s)
      AL359881, AL365194, AL590128, AL596210, KF495855, Z97635, Z98052, Z98884
      Conserved Domains (4) summary
      smart01076
      Location:67183
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      cd00204
      Location:10651186
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:10641107
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:873952
      TIG; IPT/TIG domain
    5. NM_001349610.2NP_001336539.1  calmodulin-binding transcription activator 1 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) encodes isoform f.
      Source sequence(s)
      AL359881, AL365194, AL590128, AL596210, KF495855, Z97635, Z98052, Z98884
      Conserved Domains (4) summary
      smart01076
      Location:67183
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      cd00204
      Location:10651186
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:10641107
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:873952
      TIG; IPT/TIG domain
    6. NM_001349612.2NP_001336541.1  calmodulin-binding transcription activator 1 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) encodes isoform g.
      Source sequence(s)
      AL359881, AL365194, AL590128, AL596210, KF495855, Z97635, Z98052, Z98884
      Consensus CDS
      CCDS90851.1
      UniProtKB/TrEMBL
      A0A8V8TQ65
      Related
      ENSP00000514979.1, ENST00000700415.1
      Conserved Domains (4) summary
      smart01076
      Location:37153
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      cd00204
      Location:10351156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:10341077
      ANK; ANK repeat [structural motif]
      pfam01833
      Location:843922
      TIG; IPT/TIG domain
    7. NM_001349613.1NP_001336542.1  calmodulin-binding transcription activator 1 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) encodes isoform h.
      Source sequence(s)
      AL359881, KF495855, Z98884
      UniProtKB/TrEMBL
      B4DXR3
      Conserved Domains (2) summary
      cd00204
      Location:108229
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:107150
      ANK; ANK repeat [structural motif]
    8. NM_001349614.1NP_001336543.1  calmodulin-binding transcription activator 1 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variant 11, encodes isoform i.
      Source sequence(s)
      AL359881, KF495855, Z98884
      UniProtKB/TrEMBL
      A0AA34QVU6
      Conserved Domains (2) summary
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:93185
      Ank_2; Ankyrin repeats (3 copies)
    9. NM_001349615.2NP_001336544.1  calmodulin-binding transcription activator 1 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 10, encodes isoform i.
      Source sequence(s)
      AL359881, KF495855, Z98884
      UniProtKB/TrEMBL
      A0AA34QVU6
      Related
      ENSP00000518175.1, ENST00000710285.1
      Conserved Domains (2) summary
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:93185
      Ank_2; Ankyrin repeats (3 copies)
    10. NM_001349616.2NP_001336545.1  calmodulin-binding transcription activator 1 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) encodes isoform j.
      Source sequence(s)
      AL359881, KF495855, Z98884
      UniProtKB/TrEMBL
      A0A8V8TR82
      Conserved Domains (2) summary
      cd00204
      Location:89210
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
    11. NM_001349617.1NP_001336546.1  calmodulin-binding transcription activator 1 isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variant 14, encodes isoform k.
      Source sequence(s)
      AL359881, KF495855, Z98884
      Consensus CDS
      CCDS90852.1
      UniProtKB/TrEMBL
      A0A8V8TPQ2, A0A8V8TR82
      Related
      ENSP00000514995.1, ENST00000700421.1
      Conserved Domains (2) summary
      cd00204
      Location:89210
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
    12. NM_001349618.2NP_001336547.1  calmodulin-binding transcription activator 1 isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variant 13, encodes isoform k.
      Source sequence(s)
      AL359881, KF495855, Z98884
      Consensus CDS
      CCDS90852.1
      UniProtKB/TrEMBL
      A0A8V8TPQ2, A0A8V8TR82
      Conserved Domains (2) summary
      cd00204
      Location:89210
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
    13. NM_001349619.2NP_001336548.1  calmodulin-binding transcription activator 1 isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variant 16, encodes isoform l.
      Source sequence(s)
      AL359881, KF495855, Z98884
      Consensus CDS
      CCDS90853.1
      UniProtKB/TrEMBL
      A0A8V8TQ84, A0A8V8TQA4
      Related
      ENSP00000514996.1, ENST00000700423.1
      Conserved Domains (3) summary
      cd00204
      Location:89210
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
      cl27381
      Location:435561
      Myosin_head; Myosin head (motor domain)
    14. NM_001349620.1NP_001336549.1  calmodulin-binding transcription activator 1 isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variant 15, encodes isoform l.
      Source sequence(s)
      AL359881, KF495855, Z98884
      Consensus CDS
      CCDS90853.1
      UniProtKB/TrEMBL
      A0A8V8TQ84, A0A8V8TQA4
      Conserved Domains (3) summary
      cd00204
      Location:89210
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
      cl27381
      Location:435561
      Myosin_head; Myosin head (motor domain)
    15. NM_001349621.1NP_001336550.1  calmodulin-binding transcription activator 1 isoform m

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variant 18, encodes isoform m.
      Source sequence(s)
      AL359881, KF495855, Z98884
      Consensus CDS
      CCDS90854.1
      UniProtKB/TrEMBL
      A0A8V8TQX9, A0AA34QVZ9
      Conserved Domains (2) summary
      cd00204
      Location:89210
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
    16. NM_001349622.2NP_001336551.1  calmodulin-binding transcription activator 1 isoform m

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variant 17, encodes isoform m.
      Source sequence(s)
      AL359881, KF495855, Z98884
      Consensus CDS
      CCDS90854.1
      UniProtKB/TrEMBL
      A0A8V8TQX9, A0AA34QVZ9
      Related
      ENSP00000514997.1, ENST00000700424.1
      Conserved Domains (2) summary
      cd00204
      Location:89210
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
    17. NM_001349623.1NP_001336552.1  calmodulin-binding transcription activator 1 isoform n

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variant 20, encodes isoform n.
      Source sequence(s)
      AL359881, KF495855, Z98884
      Conserved Domains (2) summary
      cd00204
      Location:89210
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
    18. NM_001349624.3NP_001336553.1  calmodulin-binding transcription activator 1 isoform n

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variant 19, encodes isoform n.
      Source sequence(s)
      AL359881, KF495855, Z98884
      Conserved Domains (2) summary
      cd00204
      Location:89210
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
    19. NM_001349625.2NP_001336554.1  calmodulin-binding transcription activator 1 isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variant 22, encodes isoform o.
      Source sequence(s)
      AL359881, KF495855, Z98884
      UniProtKB/TrEMBL
      A0A8V8TQA4
      Conserved Domains (2) summary
      cd00204
      Location:89210
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
    20. NM_001349626.2NP_001336555.1  calmodulin-binding transcription activator 1 isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variant 21, encodes isoform o.
      Source sequence(s)
      AL359881, KF495855, Z98884
      UniProtKB/TrEMBL
      A0A8V8TQA4
      Conserved Domains (2) summary
      cd00204
      Location:89210
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
    21. NM_001349627.2NP_001336556.1  calmodulin-binding transcription activator 1 isoform p

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23) encodes isoform p.
      Source sequence(s)
      AL590128
      Consensus CDS
      CCDS85922.1
      UniProtKB/TrEMBL
      G3V297
      Related
      ENSP00000450530.1, ENST00000467404.6
    22. NM_001410737.1NP_001397666.1  calmodulin-binding transcription activator 1 isoform q

      Status: REVIEWED

      Source sequence(s)
      AL359881, AL365194, AL590128, AL596210, KF495855, Z97635, Z98052, Z98884
      Consensus CDS
      CCDS90849.1
      UniProtKB/TrEMBL
      A0A0C4DGL0
      Related
      ENSP00000452319.2, ENST00000476864.2
    23. NM_001410738.1NP_001397667.1  calmodulin-binding transcription activator 1 isoform r

      Status: REVIEWED

      Source sequence(s)
      AL359881, AL590128, AL596210, KF495855, Z97635, Z98052, Z98884
      Consensus CDS
      CCDS90850.1
      UniProtKB/TrEMBL
      A0A8V8TQ87
      Related
      ENSP00000514981.1, ENST00000700417.1
    24. NM_015215.4NP_056030.1  calmodulin-binding transcription activator 1 isoform a

      See identical proteins and their annotated locations for NP_056030.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as 1).
      Source sequence(s)
      AL359881, BC151835, KF495855, Z98884
      Consensus CDS
      CCDS30576.1
      UniProtKB/Swiss-Prot
      A7MBM4, G3V3Z7, Q5VUE1, Q6V701, Q8WYI3, Q96S92, Q9Y6Y1
      Related
      ENSP00000306522.6, ENST00000303635.12
      Conserved Domains (5) summary
      smart01076
      Location:67183
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      cd00204
      Location:10651186
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01833
      Location:873952
      TIG; IPT/TIG domain
      pfam13637
      Location:11121163
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:10641107
      ANK; ANK repeat [structural motif]

    RNA

    1. NR_038934.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon and uses an alternate, 3' terminal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI278074, BC151835, BM470492
      Related
      ENST00000476163.5
    2. NR_146202.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL590128
    3. NR_146203.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL590128
    4. NR_146204.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL590128
      Related
      ENST00000490738.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      6785454..7769706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541084.3XP_011539386.1  calmodulin-binding transcription activator 1 isoform X2

      Conserved Domains (5) summary
      smart01076
      Location:67183
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      cd00204
      Location:10651186
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01833
      Location:873952
      TIG; IPT/TIG domain
      pfam13637
      Location:11121163
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:10641107
      ANK; ANK repeat [structural motif]
    2. XM_011541083.3XP_011539385.1  calmodulin-binding transcription activator 1 isoform X1

      Conserved Domains (5) summary
      smart01076
      Location:67183
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      cd00204
      Location:10651186
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01833
      Location:873952
      TIG; IPT/TIG domain
      pfam13637
      Location:11121163
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:10641107
      ANK; ANK repeat [structural motif]
    3. XM_011541086.4XP_011539388.1  calmodulin-binding transcription activator 1 isoform X4

      Conserved Domains (5) summary
      smart01076
      Location:67183
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      cd00204
      Location:10651186
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01833
      Location:873952
      TIG; IPT/TIG domain
      pfam13637
      Location:11121163
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:10641107
      ANK; ANK repeat [structural motif]
    4. XM_011541090.4XP_011539392.1  calmodulin-binding transcription activator 1 isoform X13

      Conserved Domains (5) summary
      smart01076
      Location:67183
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      cd00204
      Location:10651186
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01833
      Location:873952
      TIG; IPT/TIG domain
      pfam13637
      Location:11121163
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:10641107
      ANK; ANK repeat [structural motif]
    5. XM_017000778.2XP_016856267.1  calmodulin-binding transcription activator 1 isoform X14

    6. XM_011541087.3XP_011539389.1  calmodulin-binding transcription activator 1 isoform X6

      Conserved Domains (5) summary
      cd00204
      Location:10411162
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01833
      Location:849928
      TIG; IPT/TIG domain
      pfam13637
      Location:10881139
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:10401083
      ANK; ANK repeat [structural motif]
      cl04295
      Location:67159
      CG-1; CG-1 domain
    7. XM_047415997.1XP_047271953.1  calmodulin-binding transcription activator 1 isoform X9

    8. XM_011541088.3XP_011539390.1  calmodulin-binding transcription activator 1 isoform X8

      Conserved Domains (5) summary
      smart01076
      Location:37153
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      cd00204
      Location:10351156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01833
      Location:843922
      TIG; IPT/TIG domain
      pfam13637
      Location:10821133
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:10341077
      ANK; ANK repeat [structural motif]
    9. XM_047415999.1XP_047271955.1  calmodulin-binding transcription activator 1 isoform X10

    10. XM_047416005.1XP_047271961.1  calmodulin-binding transcription activator 1 isoform X11

    11. XM_047416024.1XP_047271980.1  calmodulin-binding transcription activator 1 isoform X15

    12. XM_017000774.3XP_016856263.1  calmodulin-binding transcription activator 1 isoform X5

    13. XM_047415993.1XP_047271949.1  calmodulin-binding transcription activator 1 isoform X7

    14. XM_011541091.3XP_011539393.1  calmodulin-binding transcription activator 1 isoform X16

      Conserved Domains (2) summary
      smart01076
      Location:67183
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      pfam01833
      Location:873952
      TIG; IPT/TIG domain
    15. XM_011541092.4XP_011539394.1  calmodulin-binding transcription activator 1 isoform X17

      Conserved Domains (2) summary
      smart01076
      Location:67183
      CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues
      pfam01833
      Location:873952
      TIG; IPT/TIG domain
    16. XM_017000780.3XP_016856269.1  calmodulin-binding transcription activator 1 isoform X22

    17. XM_017000781.2XP_016856270.1  calmodulin-binding transcription activator 1 isoform X23

    18. XM_047415988.1XP_047271944.1  calmodulin-binding transcription activator 1 isoform X3

    19. XM_047416009.1XP_047271965.1  calmodulin-binding transcription activator 1 isoform X12

    20. XM_024454334.1XP_024310102.1  calmodulin-binding transcription activator 1 isoform X21

      UniProtKB/TrEMBL
      A0A8V8TR82
      Related
      ENSP00000514994.1, ENST00000700420.1
      Conserved Domains (2) summary
      cd00204
      Location:89210
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
    21. XM_024454329.2XP_024310097.1  calmodulin-binding transcription activator 1 isoform X18

      UniProtKB/TrEMBL
      A0AA34QVU6
      Conserved Domains (2) summary
      cd00204
      Location:152273
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:151194
      ANK; ANK repeat [structural motif]
    22. XM_024454330.2XP_024310098.1  calmodulin-binding transcription activator 1 isoform X19

      UniProtKB/TrEMBL
      B4DXR3
      Conserved Domains (2) summary
      cd00204
      Location:152273
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:151194
      ANK; ANK repeat [structural motif]
    23. XM_024454332.2XP_024310100.1  calmodulin-binding transcription activator 1 isoform X20

      UniProtKB/TrEMBL
      A0AA34QVU6
      Conserved Domains (2) summary
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:93185
      Ank_2; Ankyrin repeats (3 copies)
    24. XM_024454331.2XP_024310099.1  calmodulin-binding transcription activator 1 isoform X20

      UniProtKB/TrEMBL
      A0AA34QVU6
      Conserved Domains (2) summary
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:93185
      Ank_2; Ankyrin repeats (3 copies)
    25. XM_024454333.2XP_024310101.1  calmodulin-binding transcription activator 1 isoform X20

      UniProtKB/TrEMBL
      A0AA34QVU6
      Conserved Domains (2) summary
      sd00045
      Location:88131
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:93185
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. XR_001737064.2 RNA Sequence

    2. XR_001737062.2 RNA Sequence

    3. XR_007057950.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      6313294..7300752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335420.1XP_054191395.1  calmodulin-binding transcription activator 1 isoform X2

    2. XM_054335419.1XP_054191394.1  calmodulin-binding transcription activator 1 isoform X1

    3. XM_054335422.1XP_054191397.1  calmodulin-binding transcription activator 1 isoform X4

    4. XM_054335431.1XP_054191406.1  calmodulin-binding transcription activator 1 isoform X13

    5. XM_054335432.1XP_054191407.1  calmodulin-binding transcription activator 1 isoform X14

    6. XM_054335424.1XP_054191399.1  calmodulin-binding transcription activator 1 isoform X6

    7. XM_054335427.1XP_054191402.1  calmodulin-binding transcription activator 1 isoform X9

    8. XM_054335426.1XP_054191401.1  calmodulin-binding transcription activator 1 isoform X8

    9. XM_054335428.1XP_054191403.1  calmodulin-binding transcription activator 1 isoform X10

    10. XM_054335429.1XP_054191404.1  calmodulin-binding transcription activator 1 isoform X11

    11. XM_054335433.1XP_054191408.1  calmodulin-binding transcription activator 1 isoform X15

    12. XM_054335423.1XP_054191398.1  calmodulin-binding transcription activator 1 isoform X5

    13. XM_054335425.1XP_054191400.1  calmodulin-binding transcription activator 1 isoform X7

    14. XM_054335435.1XP_054191410.1  calmodulin-binding transcription activator 1 isoform X17

    15. XM_054335434.1XP_054191409.1  calmodulin-binding transcription activator 1 isoform X16

    16. XM_054335443.1XP_054191418.1  calmodulin-binding transcription activator 1 isoform X24

    17. XM_054335442.1XP_054191417.1  calmodulin-binding transcription activator 1 isoform X22

    18. XM_054335444.1XP_054191419.1  calmodulin-binding transcription activator 1 isoform X23

    19. XM_054335421.1XP_054191396.1  calmodulin-binding transcription activator 1 isoform X3

    20. XM_054335430.1XP_054191405.1  calmodulin-binding transcription activator 1 isoform X12

    21. XM_054335441.1XP_054191416.1  calmodulin-binding transcription activator 1 isoform X21

      UniProtKB/TrEMBL
      A0A8V8TR82
    22. XM_054335436.1XP_054191411.1  calmodulin-binding transcription activator 1 isoform X18

      UniProtKB/TrEMBL
      A0AA34QVU6
    23. XM_054335437.1XP_054191412.1  calmodulin-binding transcription activator 1 isoform X19

      UniProtKB/TrEMBL
      B4DXR3
    24. XM_054335439.1XP_054191414.1  calmodulin-binding transcription activator 1 isoform X20

      UniProtKB/TrEMBL
      A0AA34QVU6
    25. XM_054335438.1XP_054191413.1  calmodulin-binding transcription activator 1 isoform X20

      UniProtKB/TrEMBL
      A0AA34QVU6
    26. XM_054335440.1XP_054191415.1  calmodulin-binding transcription activator 1 isoform X20

      UniProtKB/TrEMBL
      A0AA34QVU6

    RNA

    1. XR_008485965.1 RNA Sequence

    2. XR_008485966.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001349628.1: Suppressed sequence

      Description
      NM_001349628.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.