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    TOE1 target of EGR1, exonuclease [ Homo sapiens (human) ]

    Gene ID: 114034, updated on 11-Apr-2024

    Summary

    Official Symbol
    TOE1provided by HGNC
    Official Full Name
    target of EGR1, exonucleaseprovided by HGNC
    Primary source
    HGNC:HGNC:15954
    See related
    Ensembl:ENSG00000132773 MIM:613931; AllianceGenome:HGNC:15954
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCH7; TOE-1; hCaf1z
    Summary
    Enables poly(A)-specific ribonuclease activity and snRNA binding activity. Involved in RNA phosphodiester bond hydrolysis, exonucleolytic and snRNA 3'-end processing. Located in Cajal body and cytoplasm. Implicated in pontocerebellar hypoplasia type 7. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 7.9), bone marrow (RPKM 5.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TOE1 in Genome Data Viewer
    Location:
    1p34.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (45340170..45343973)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (45211720..45215530)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45805842..45809645)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 962 Neighboring gene long intergenic non-protein coding RNA 1144 Neighboring gene Sharpr-MPRA regulatory region 12838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 965 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:45795127-45796061 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45805164-45805831 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:45805832-45806500 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:45806501-45807167 Neighboring gene mutY DNA glycosylase Neighboring gene 4-hydroxyphenylpyruvate dioxygenase like Neighboring gene uncharacterized LOC124904849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:45826137-45826636 Neighboring gene testis associated actin remodelling kinase 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:45856236-45856736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 969 Neighboring gene peptidylprolyl isomerase A pseudogene 36

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, target of EGR1 member 1 (TOE1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with TOE1 is increased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13949

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3'-5'-RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A)-specific ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables snRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in snRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Cajal body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    target of EGR1 protein 1
    Names
    target of EGR1, member 1 (nuclear)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025077.4NP_079353.3  target of EGR1 protein 1

      See identical proteins and their annotated locations for NP_079353.3

      Status: VALIDATED

      Source sequence(s)
      AY169960, BC009364, DA887065
      Consensus CDS
      CCDS521.1
      UniProtKB/Swiss-Prot
      B4DEM6, Q6IA35, Q8IWN5, Q96GM8, Q9H846
      Related
      ENSP00000361162.5, ENST00000372090.6
      Conserved Domains (2) summary
      pfam00642
      Location:297320
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam04857
      Location:41257
      CAF1; CAF1 family ribonuclease

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      45340170..45343973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005270413.6XP_005270470.1  target of EGR1 protein 1 isoform X2

      Related
      ENST00000495703.5
      Conserved Domains (2) summary
      pfam00642
      Location:251274
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam04857
      Location:2211
      CAF1; CAF1 family ribonuclease
    2. XM_005270412.5XP_005270469.1  target of EGR1 protein 1 isoform X1

      Conserved Domains (2) summary
      pfam00642
      Location:303326
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam04857
      Location:47263
      CAF1; CAF1 family ribonuclease
    3. XM_047443512.1XP_047299468.1  target of EGR1 protein 1 isoform X5

      Related
      ENST00000471337.5
    4. XM_047443500.1XP_047299456.1  target of EGR1 protein 1 isoform X3

    5. XM_047443504.1XP_047299460.1  target of EGR1 protein 1 isoform X4

      UniProtKB/TrEMBL
      B4DP23

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      45211720..45215530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334064.1XP_054190039.1  target of EGR1 protein 1 isoform X1

    2. XM_054334068.1XP_054190043.1  target of EGR1 protein 1 isoform X5

    3. XM_054334066.1XP_054190041.1  target of EGR1 protein 1 isoform X3

    4. XM_054334067.1XP_054190042.1  target of EGR1 protein 1 isoform X4

      UniProtKB/TrEMBL
      B4DP23
    5. XM_054334065.1XP_054190040.1  target of EGR1 protein 1 isoform X2