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    SNRPE small nuclear ribonucleoprotein polypeptide E [ Homo sapiens (human) ]

    Gene ID: 6635, updated on 4-Feb-2024

    Summary

    Official Symbol
    SNRPEprovided by HGNC
    Official Full Name
    small nuclear ribonucleoprotein polypeptide Eprovided by HGNC
    Primary source
    HGNC:HGNC:11161
    See related
    Ensembl:ENSG00000182004 MIM:128260; AllianceGenome:HGNC:11161
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SME; Sm-E; HYPT11; snRNP-E
    Summary
    The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing of histone transcripts. This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in this gene have been associated with hypotrichosis. Several pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2016]
    Expression
    Ubiquitous expression in colon (RPKM 16.8), ovary (RPKM 16.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SNRPE in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (203861599..203871152)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (203125550..203135078)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (203830727..203840280)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 11A Neighboring gene charged multivesicular body protein 5 pseudogene Neighboring gene zinc finger BED-type containing 6 Neighboring gene MPRA-validated peak661 silencer Neighboring gene ribosomal protein L35a pseudogene 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:203810670-203811170 Neighboring gene Sharpr-MPRA regulatory region 5904 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:203831257-203831832 Neighboring gene keratin 8 pseudogene 29 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:203857413-203858612 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, small nuclear ribonucleoprotein polypeptide E (SNRPE), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SNRPE is increased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SMN-Sm protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of U1 snRNP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U1 snRNP IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of U1 snRNP NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of U12-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of U2 snRNP NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of U2-type catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U2-type precatalytic spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U2-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U4 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of U4 snRNP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U4 snRNP NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U4/U6 x U5 tri-snRNP complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of U5 snRNP NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of U7 snRNP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of methylosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of pICln-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of pICln-Sm protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of small nuclear ribonucleoprotein complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of spliceosomal complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of spliceosomal complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of telomerase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    small nuclear ribonucleoprotein E
    Names
    sm protein E

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050954.2 RefSeqGene

      Range
      5002..14555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001304464.2NP_001291393.1  small nuclear ribonucleoprotein E isoform 2

      See identical proteins and their annotated locations for NP_001291393.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses two alternate splice junctions in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC114402, AC118554
      UniProtKB/Swiss-Prot
      P62304
      Conserved Domains (1) summary
      cd01718
      Location:1181
      Sm_E; Sm protein E
    2. NM_001328637.2NP_001315566.1  small nuclear ribonucleoprotein E isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC114402, AC118554
      UniProtKB/Swiss-Prot
      P62304
    3. NM_001328638.2NP_001315567.1  small nuclear ribonucleoprotein E isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC114402, AC118554
      UniProtKB/Swiss-Prot
      P62304
    4. NM_003094.4NP_003085.1  small nuclear ribonucleoprotein E isoform 1

      See identical proteins and their annotated locations for NP_003085.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC114402, AC118554
      Consensus CDS
      CCDS30979.1
      UniProtKB/Swiss-Prot
      B2R5B9, P08578, P62304, Q15498, Q5BKT2
      Related
      ENSP00000400591.2, ENST00000414487.7
      Conserved Domains (1) summary
      cd01718
      Location:1189
      Sm_E; Sm protein E

    RNA

    1. NR_130746.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) utilizes an alternate splice junction in the 5' end and lacks an alternate in-frame exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC114402, AC118554

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      203861599..203871152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      203125550..203135078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)