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    RBP4 retinol binding protein 4 [ Homo sapiens (human) ]

    Gene ID: 5950, updated on 5-Mar-2024

    Summary

    Official Symbol
    RBP4provided by HGNC
    Official Full Name
    retinol binding protein 4provided by HGNC
    Primary source
    HGNC:HGNC:9922
    See related
    Ensembl:ENSG00000138207 MIM:180250; AllianceGenome:HGNC:9922
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RDCCAS; MCOPCB10
    Summary
    This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in liver (RPKM 2545.8) and fat (RPKM 387.7) See more
    Orthologs
    NEW
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    Genomic context

    See RBP4 in Genome Data Viewer
    Location:
    10q23.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (93591694..93601744, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (94471646..94481695, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (95351451..95361501, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:95315968-95316468 Neighboring gene uncharacterized LOC105378436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:95325824-95326662 Neighboring gene uncharacterized LOC124902485 Neighboring gene free fatty acid receptor 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:95341272-95341477 Neighboring gene phosphodiesterase 6C Neighboring gene FRA10A associated CGG repeat 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3786 Neighboring gene fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retinal binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables retinol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables retinol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables retinol transmembrane transporter activity IC
    Inferred by Curator
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cardiac muscle tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in embryonic organ morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in embryonic retina morphogenesis in camera-type eye ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in embryonic skeletal system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in female genitalia morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucose homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heart trabecula formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lung development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in maintenance of gastrointestinal epithelium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cardiac muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of immunoglobulin production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retinol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retinol transport IC
    Inferred by Curator
    more info
    PubMed 
    involved_in urinary bladder development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in uterus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vagina development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    retinol-binding protein 4
    Names
    PRBP
    RBP
    plasma retinol-binding protein
    retinol binding protein 4, plasma
    retinol-binding protein 4, interstitial

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009104.1 RefSeqGene

      Range
      5002..14543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001323517.1NP_001310446.1  retinol-binding protein 4 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) and variant 1 both encode isoform a.
      Source sequence(s)
      AL356214
      Consensus CDS
      CCDS31249.1
      UniProtKB/Swiss-Prot
      D3DR38, O43478, O43479, P02753, Q5VY24, Q8WWA3, Q9P178
      Related
      ENSP00000360522.1, ENST00000371467.5
      Conserved Domains (1) summary
      cd00743
      Location:22192
      lipocalin_RBP_like; retinol-binding protein 4 and similar proteins
    2. NM_001323518.2NP_001310447.1  retinol-binding protein 4 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL356214, BC020633, BG565176, BI712834
      Consensus CDS
      CCDS81488.1
      UniProtKB/TrEMBL
      Q5VY30
      Related
      ENSP00000360524.2, ENST00000371469.2
      Conserved Domains (1) summary
      pfam00061
      Location:37175
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    3. NM_006744.4NP_006735.2  retinol-binding protein 4 isoform a precursor

      See identical proteins and their annotated locations for NP_006735.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variant 2 both encode isoform a.
      Source sequence(s)
      AL356214, BC020633, BX495987, X00129
      Consensus CDS
      CCDS31249.1
      UniProtKB/Swiss-Prot
      D3DR38, O43478, O43479, P02753, Q5VY24, Q8WWA3, Q9P178
      Related
      ENSP00000360519.3, ENST00000371464.8
      Conserved Domains (1) summary
      cd00743
      Location:22192
      lipocalin_RBP_like; retinol-binding protein 4 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      93591694..93601744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      94471646..94481695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)