U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from MedGen

    • Showing Current items.

    MPDZ multiple PDZ domain crumbs cell polarity complex component [ Homo sapiens (human) ]

    Gene ID: 8777, updated on 15-Jan-2024

    Summary

    Official Symbol
    MPDZprovided by HGNC
    Official Full Name
    multiple PDZ domain crumbs cell polarity complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:7208
    See related
    Ensembl:ENSG00000107186 MIM:603785; AllianceGenome:HGNC:7208
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HYC2; MUPP1
    Summary
    The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in liver (RPKM 12.7), fat (RPKM 10.5) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MPDZ in Genome Data Viewer
    Location:
    9p23
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (13105707..13279692, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (13115022..13289091, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (13105706..13279691, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 137 Neighboring gene peroxiredoxin 1 pseudogene 1 Neighboring gene lupus La protein-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:13037568-13038084 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:13251447-13252059 Neighboring gene Sharpr-MPRA regulatory region 14432 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:13277167-13277882 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:13277883-13278598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:13278599-13279314 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:13369413-13369918 Neighboring gene long intergenic non-protein coding RNA 1235 Neighboring gene uncharacterized LOC105375977

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Hydrocephalus, nonsyndromic, autosomal recessive 2
    MedGen: C3554691 OMIM: 615219 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of multiple PDZ domain protein (MPDZ) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ25909, FLJ34626, FLJ90240, DKFZp781P216

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in apical part of cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    multiple PDZ domain protein
    Names
    multi-PDZ domain protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042810.2 RefSeqGene

      Range
      5000..178985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001261406.2NP_001248335.1  multiple PDZ domain protein isoform 2

      See identical proteins and their annotated locations for NP_001248335.1

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS59120.1
      UniProtKB/TrEMBL
      F5H1U9
      Related
      ENSP00000415208.1, ENST00000447879.6
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:15291593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    2. NM_001261407.2NP_001248336.1  multiple PDZ domain protein isoform 3

      See identical proteins and their annotated locations for NP_001248336.1

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS59119.1
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:15291593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    3. NM_001330637.2NP_001317566.1  multiple PDZ domain protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS83342.1
      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2; L27_2
      pfam16667
      Location:15621626
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    4. NM_001375413.1NP_001362342.1  multiple PDZ domain protein isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:15951659
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    5. NM_001375416.1NP_001362345.1  multiple PDZ domain protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS59120.1
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:15291593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    6. NM_001375417.1NP_001362346.1  multiple PDZ domain protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS59120.1
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:15291593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    7. NM_001375418.1NP_001362347.1  multiple PDZ domain protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS59120.1
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:15291593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    8. NM_001375419.1NP_001362348.1  multiple PDZ domain protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS59119.1
      UniProtKB/TrEMBL
      F5H1U9
      Related
      ENSP00000444151.1, ENST00000536827.5
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:15291593
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    9. NM_001375420.1NP_001362349.1  multiple PDZ domain protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:19161999
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:14921556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    10. NM_001375421.1NP_001362350.1  multiple PDZ domain protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:19161999
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:14921556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    11. NM_001375422.1NP_001362351.1  multiple PDZ domain protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:19161999
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:14921556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    12. NM_001375423.1NP_001362352.1  multiple PDZ domain protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:19161999
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:14921556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    13. NM_001375424.1NP_001362353.1  multiple PDZ domain protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:19161999
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:14921556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    14. NM_001375425.1NP_001362354.1  multiple PDZ domain protein isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:18871970
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:14921556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    15. NM_001375426.1NP_001362355.1  multiple PDZ domain protein isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:18871970
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:14921556
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    16. NM_001375427.1NP_001362356.1  multiple PDZ domain protein isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:18501933
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:14261490
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    17. NM_001378778.1NP_001365707.1  multiple PDZ domain protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS83342.1
      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
      Related
      ENSP00000320006.7, ENST00000319217.12
    18. NM_003829.5NP_003820.2  multiple PDZ domain protein isoform 1

      See identical proteins and their annotated locations for NP_003820.2

      Status: REVIEWED

      Source sequence(s)
      AL161449, AL162386, AL353639, KF458902
      Consensus CDS
      CCDS47951.1
      UniProtKB/TrEMBL
      F5H1U9
      Related
      ENSP00000439807.1, ENST00000541718.5
      Conserved Domains (4) summary
      pfam09045
      Location:663
      L27_2; L27_2
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16667
      Location:15621626
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      13105707..13279692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424033.1XP_047279989.1  multiple PDZ domain protein isoform X5

      UniProtKB/TrEMBL
      F5H1U9
    2. XM_017015252.2XP_016870741.1  multiple PDZ domain protein isoform X2

      UniProtKB/TrEMBL
      F5H1U9
    3. XM_006716888.4XP_006716951.1  multiple PDZ domain protein isoform X3

      See identical proteins and their annotated locations for XP_006716951.1

      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      pfam09045
      Location:663
      L27_2; L27_2
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16667
      Location:15621626
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    4. XM_047424044.1XP_047280000.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    5. XM_047424016.1XP_047279972.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    6. XM_047424035.1XP_047279991.1  multiple PDZ domain protein isoform X6

      UniProtKB/TrEMBL
      F5H1U9
    7. XM_006716886.4XP_006716949.1  multiple PDZ domain protein isoform X1

      See identical proteins and their annotated locations for XP_006716949.1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2; L27_2
      pfam16667
      Location:15621626
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    8. XM_047424042.1XP_047279998.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    9. XM_047424025.1XP_047279981.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9
    10. XM_024447708.2XP_024303476.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2; L27_2
      pfam16667
      Location:15621626
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    11. XM_047424039.1XP_047279995.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    12. XM_047424028.1XP_047279984.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9
    13. XM_047424013.1XP_047279969.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    14. XM_047424045.1XP_047280001.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    15. XM_047424015.1XP_047279971.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    16. XM_047424043.1XP_047279999.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    17. XM_047424031.1XP_047279987.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9
    18. XM_047424046.1XP_047280002.1  multiple PDZ domain protein isoform X9

      UniProtKB/TrEMBL
      F5H1U9
      Conserved Domains (4) summary
      smart00228
      Location:374463
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:11491240
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09045
      Location:663
      L27_2
      pfam16667
      Location:15951659
      MPDZ_u10; Unstructured region 10 on multiple PDZ protein
    19. XM_047424037.1XP_047279993.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    20. XM_047424034.1XP_047279990.1  multiple PDZ domain protein isoform X6

      UniProtKB/TrEMBL
      F5H1U9
    21. XM_047424023.1XP_047279979.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9
    22. XM_047424009.1XP_047279965.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    23. XM_047424022.1XP_047279978.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    24. XM_054328427.1XP_054184402.1  multiple PDZ domain protein isoform X7

      UniProtKB/TrEMBL
      F5H1U9
    25. XM_047424012.1XP_047279968.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    26. XM_047424036.1XP_047279992.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    27. XM_047424024.1XP_047279980.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9
    28. XM_047424010.1XP_047279966.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    29. XM_047424026.1XP_047279982.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9
    30. XM_047424014.1XP_047279970.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    31. XM_047424020.1XP_047279976.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    32. XM_047424019.1XP_047279975.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    33. XM_047424018.1XP_047279974.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    34. XM_047424038.1XP_047279994.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    35. XM_047424029.1XP_047279985.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9
    36. XM_047424017.1XP_047279973.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    37. XM_047424027.1XP_047279983.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9
    38. XM_047424041.1XP_047279997.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    39. XM_047424032.1XP_047279988.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      13115022..13289091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364122.1XP_054220097.1  multiple PDZ domain protein isoform X7

      UniProtKB/TrEMBL
      F5H1U9
    2. XM_054364112.1XP_054220087.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9
    3. XM_054364100.1XP_054220075.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    4. XM_054364115.1XP_054220090.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9
    5. XM_054364098.1XP_054220073.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    6. XM_054364119.1XP_054220094.1  multiple PDZ domain protein isoform X5

      UniProtKB/TrEMBL
      F5H1U9
    7. XM_054364108.1XP_054220083.1  multiple PDZ domain protein isoform X2

      UniProtKB/TrEMBL
      F5H1U9
    8. XM_054364109.1XP_054220084.1  multiple PDZ domain protein isoform X3

      UniProtKB/TrEMBL
      F5H1U9
    9. XM_054364131.1XP_054220106.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    10. XM_054364102.1XP_054220077.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    11. XM_054364121.1XP_054220096.1  multiple PDZ domain protein isoform X6

      UniProtKB/TrEMBL
      F5H1U9
    12. XM_054364095.1XP_054220070.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    13. XM_054364129.1XP_054220104.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    14. XM_054364127.1XP_054220102.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    15. XM_054364132.1XP_054220107.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    16. XM_054364101.1XP_054220076.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    17. XM_054364130.1XP_054220105.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    18. XM_054364117.1XP_054220092.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9
    19. XM_054364125.1XP_054220100.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    20. XM_054364120.1XP_054220095.1  multiple PDZ domain protein isoform X6

      UniProtKB/TrEMBL
      F5H1U9
    21. XM_054364110.1XP_054220085.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9
    22. XM_054364094.1XP_054220069.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    23. XM_054364107.1XP_054220082.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    24. XM_054364123.1XP_054220098.1  multiple PDZ domain protein isoform X7

      UniProtKB/TrEMBL
      F5H1U9
    25. XM_054364097.1XP_054220072.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    26. XM_054364124.1XP_054220099.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    27. XM_054364111.1XP_054220086.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9
    28. XM_054364096.1XP_054220071.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    29. XM_054364113.1XP_054220088.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9
    30. XM_054364099.1XP_054220074.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    31. XM_054364106.1XP_054220081.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    32. XM_054364105.1XP_054220080.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    33. XM_054364104.1XP_054220079.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    34. XM_054364126.1XP_054220101.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    35. XM_054364116.1XP_054220091.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9
    36. XM_054364103.1XP_054220078.1  multiple PDZ domain protein isoform X1

      UniProtKB/Swiss-Prot
      A6NLC2, B2RTS3, B7ZMI4, O43798, O75970, Q4LE30, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790
      UniProtKB/TrEMBL
      F5H1U9
    37. XM_054364114.1XP_054220089.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9
    38. XM_054364133.1XP_054220108.1  multiple PDZ domain protein isoform X9

      UniProtKB/TrEMBL
      F5H1U9
    39. XM_054364128.1XP_054220103.1  multiple PDZ domain protein isoform X8

      UniProtKB/TrEMBL
      F5H1U9
    40. XM_054364118.1XP_054220093.1  multiple PDZ domain protein isoform X4

      UniProtKB/TrEMBL
      F5H1U9