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    HSF4 heat shock transcription factor 4 [ Homo sapiens (human) ]

    Gene ID: 3299, updated on 23-Nov-2023

    Summary

    Official Symbol
    HSF4provided by HGNC
    Official Full Name
    heat shock transcription factor 4provided by HGNC
    Primary source
    HGNC:HGNC:5227
    See related
    Ensembl:ENSG00000102878 MIM:602438; AllianceGenome:HGNC:5227
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CTM; CTRCT5
    Summary
    Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 12.6), skin (RPKM 8.5) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HSF4 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67163761..67169941)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72958053..72964234)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67197664..67203844)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene phagosome assembly factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7581 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67189519-67190420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67195788-67196300 Neighboring gene TNFRSF1A associated via death domain Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67196374-67197322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67197323-67198271 Neighboring gene Sharpr-MPRA regulatory region 11796 Neighboring gene F-box and leucine rich repeat protein 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7588 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67206328-67206491 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67207408-67208330 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67209861-67210290 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67211873-67212416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67212417-67212958 Neighboring gene nucleolar protein 3 Neighboring gene microtubule associated tyrosine carboxypeptidase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10956 Neighboring gene exocyst complex component 3 like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in lens fiber cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    heat shock factor protein 4
    Names
    HSF 4
    HSTF 4
    hHSF4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009294.1 RefSeqGene

      Range
      6361..11557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001040667.3NP_001035757.1  heat shock factor protein 4 isoform b

      See identical proteins and their annotated locations for NP_001035757.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1, resulting in a longer protein (isoform b). This variant, alternatively referred to as HSF4b, functions as a transcriptional activator of the constitutive expression of heat shock genes.
      Source sequence(s)
      AC074143, AK307211, BC130383, BX348481, CA412687
      Consensus CDS
      CCDS42175.1
      UniProtKB/Swiss-Prot
      Q99472, Q9ULV5, Q9ULV6
      UniProtKB/TrEMBL
      E5RK26
      Conserved Domains (3) summary
      smart00415
      Location:16120
      HSF; heat shock factor
      pfam06546
      Location:259443
      Vert_HS_TF; Vertebrate heat shock transcription factor
      pfam15035
      Location:110175
      Rootletin; Ciliary rootlet component, centrosome cohesion
    2. NM_001374674.1NP_001361603.1  heat shock factor protein 4 isoform a

      Status: REVIEWED

      Source sequence(s)
      AK225152, AK293631, D87673
      Consensus CDS
      CCDS45510.1
      UniProtKB/TrEMBL
      E5RK26
      Related
      ENSP00000463706.1, ENST00000584272.5
      Conserved Domains (2) summary
      smart00415
      Location:16120
      HSF; heat shock factor
      pfam15035
      Location:110175
      Rootletin; Ciliary rootlet component, centrosome cohesion
    3. NM_001374675.1NP_001361604.1  heat shock factor protein 4 isoform b

      Status: REVIEWED

      Source sequence(s)
      AB029348, AC074143, AK293631, D87673
      Consensus CDS
      CCDS42175.1
      UniProtKB/Swiss-Prot
      Q99472, Q9ULV5, Q9ULV6
      UniProtKB/TrEMBL
      E5RK26
      Related
      ENSP00000430947.2, ENST00000521374.6
      Conserved Domains (3) summary
      smart00415
      Location:16120
      HSF; heat shock factor
      pfam06546
      Location:259443
      Vert_HS_TF; Vertebrate heat shock transcription factor
      pfam15035
      Location:110175
      Rootletin; Ciliary rootlet component, centrosome cohesion
    4. NM_001538.4NP_001529.2  heat shock factor protein 4 isoform a

      See identical proteins and their annotated locations for NP_001529.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shorter protein (isoform a). This variant, alternatively referred to as HSF4a, functions as an inhibitor of the constitutive expression of heat shock genes.
      Source sequence(s)
      AK307211, BX348481, CA412687, D87673
      Consensus CDS
      CCDS45510.1
      UniProtKB/TrEMBL
      E5RK26
      Conserved Domains (2) summary
      smart00415
      Location:16120
      HSF; heat shock factor
      pfam15035
      Location:110175
      Rootletin; Ciliary rootlet component, centrosome cohesion

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      67163761..67169941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      72958053..72964234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)