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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_013061.1 RefSeqGene
- Range
-
5031..28575
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_000191.3 → NP_000182.2 hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1 precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longer isoform (1).
- Source sequence(s)
-
AI202943, AL031295, AL590728
- Consensus CDS
-
CCDS243.1
- UniProtKB/Swiss-Prot
- B4DUP4, B7UCC6, D3Y5K7, P35914, Q6IBC0, Q96FP8
- UniProtKB/TrEMBL
- A6NMQ0, B1AK13
- Related
- ENSP00000363614.3, ENST00000374490.8
- Conserved Domains (1) summary
-
- cd07938
Location:35 → 308
- DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain
-
NM_001166059.2 → NP_001159531.1 hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 2 precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant is missing two consecutive in-frame coding exons compared to variant 1, resulting in a shorter isoform (2) lacking an internal protein segment compared to isoform 1.
- Source sequence(s)
-
BC010570, CA306929, DA425822, L07033
- Consensus CDS
-
CCDS53279.1
- UniProtKB/Swiss-Prot
-
P35914
- Related
- ENSP00000389281.2, ENST00000436439.6
- Conserved Domains (2) summary
-
- PLN02746
Location:17 → 254
- PLN02746; hydroxymethylglutaryl-CoA lyase
- pfam00682
Location:32 → 235
- HMGL-like; HMGL-like
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000001.11 Reference GRCh38.p14 Primary Assembly
- Range
-
23801885..23825429 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060925.1 Alternate T2T-CHM13v2.0
- Range
-
23636860..23660403 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)