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    SLC11A2 solute carrier family 11 member 2 [ Homo sapiens (human) ]

    Gene ID: 4891, updated on 3-Apr-2024

    Summary

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    Official Symbol
    SLC11A2provided by HGNC
    Official Full Name
    solute carrier family 11 member 2provided by HGNC
    Primary source
    HGNC:HGNC:10908
    See related
    Ensembl:ENSG00000110911 MIM:600523; AllianceGenome:HGNC:10908
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCT1; DMT1; AHMIO1; NRAMP2
    Summary
    This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]
    Expression
    Ubiquitous expression in duodenum (RPKM 12.8), thyroid (RPKM 12.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    12q13.12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (50952263..51028886, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (50915621..50992224, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51373190..51422669, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51251231-51251732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51251733-51252232 Neighboring gene CRISPRi-validated cis-regulatory element chr12.1615 Neighboring gene MPRA-validated peak1732 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6365 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:51319135-51319678 Neighboring gene Sharpr-MPRA regulatory region 4642 Neighboring gene thiol methyltransferase 1A Neighboring gene HIG1 hypoxia inducible domain family member 1C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51346409-51346909 Neighboring gene MPRA-validated peak1733 silencer Neighboring gene RNA, U7 small nuclear 39 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51419127-51419740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51419741-51420352 Neighboring gene RNA, U6 small nuclear 87, pseudogene Neighboring gene RNA, U6 small nuclear 1273, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51441816-51442354 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51442355-51442893 Neighboring gene LETM1 domain containing 1 Neighboring gene cysteine and serine rich nuclear protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SLC11A2: a promising biomarker and therapeutic target in ovarian cancer. Tian L, et al. Sci Rep, 2023 Jan 20. PMID 36670142, Free PMC Article
    2. Genotypic Effect of IVS4+44C>A and c.2044T>C DMT1 Gene Mutations on Pathophysiology of Iron-Deficiency Anemia. Pandey S, et al. Indian J Pediatr, 2022 Sep. PMID 35857262
    3. DOES SLC11A2 GENE MUTATION ASSOCIATE WITH IRON-REFRACTORY IRON-DEFICIENCY ANEMIA AFTER BARIATRIC SURGERY? Piatto VB, et al. Arq Bras Cir Dig, 2022. PMID 35730874, Free PMC Article
    4. Evaluation of divalent metal transporter 1 (DMT1) (rs224589) polymorphism on blood lead levels of occupationally exposed individuals. Mani MS, et al. Toxicol Lett, 2021 Dec 15. PMID 34626817
    5. Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds. Manatschal C, et al. Elife, 2019 Dec 5. PMID 31804182, Free PMC Article

    See all (134) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth.
      Title: DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth.
    2. DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis.
      Title: DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis.
    3. SLC11A2: a promising biomarker and therapeutic target in ovarian cancer.
      Title: SLC11A2: a promising biomarker and therapeutic target in ovarian cancer.
    4. Genotypic Effect of IVS4+44C>A and c.2044T>C DMT1 Gene Mutations on Pathophysiology of Iron-Deficiency Anemia.
      Title: Genotypic Effect of IVS4+44C>A and c.2044T>C DMT1 Gene Mutations on Pathophysiology of Iron-Deficiency Anemia.
    5. Regulation of Iron-Ion Transporter SLC11A2 by Three Identical miRNAs.
      Title: Regulation of Iron-Ion Transporter SLC11A2 by Three Identical miRNAs.
    6. The Associations between Metalloestrogens, GSTP1, and SLC11A2 Polymorphism and the Risk of Endometrial Cancer.
      Title: The Associations between Metalloestrogens, GSTP1, and SLC11A2 Polymorphism and the Risk of Endometrial Cancer.
    7. DOES SLC11A2 GENE MUTATION ASSOCIATE WITH IRON-REFRACTORY IRON-DEFICIENCY ANEMIA AFTER BARIATRIC SURGERY?
      Title: DOES SLC11A2 GENE MUTATION ASSOCIATE WITH IRON-REFRACTORY IRON-DEFICIENCY ANEMIA AFTER BARIATRIC SURGERY?
    8. Evaluation of divalent metal transporter 1 (DMT1) (rs224589) polymorphism on blood lead levels of occupationally exposed individuals.
      Title: Evaluation of divalent metal transporter 1 (DMT1) (rs224589) polymorphism on blood lead levels of occupationally exposed individuals.
    9. Mutation analysis of seven SLC family transporters for early-onset Parkinson's disease in Chinese population.
      Title: Mutation analysis of seven SLC family transporters for early-onset Parkinson's disease in Chinese population.
    10. Human placental cell line HTR-8/SVneo accumulates cadmium by divalent metal transporters DMT1 and ZIP14.
      Title: Human placental cell line HTR-8/SVneo accumulates cadmium by divalent metal transporters DMT1 and ZIP14.
    Submit: New GeneRIF Correction See all GeneRIFs (92)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Microcytic anemia with liver iron overload
    MedGen: C3806153 OMIM: 206100 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 and the viral protein Tat modulate the expression of solute carrier family 11, member 2 (SLC11A2; proton-coupled divalent metal ion transporter) in immature dendritic PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ37416

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadmium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadmium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cadmium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadmium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cobalt ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferrous iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferrous iron transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ferrous iron transmembrane transporter activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables iron ion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables lead ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lead ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables manganese ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nickel cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables solute:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transition metal ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cadmium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cobalt ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in copper ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in copper ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in erythrocyte development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular iron ion homeostasis TAS
    Traceable Author Statement
    more info
    		  
    involved_in iron import into cell NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in iron ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in iron ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lead ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in learning or memory IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in manganese ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in manganese ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in manganese ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in multicellular organismal-level iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nickel cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to iron ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basal part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in brush border membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane HDA PubMed 
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of paraferritin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    natural resistance-associated macrophage protein 2
    Names
    DMT-1
    NRAMP 2
    divalent cation transporter 1
    solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
    solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021139.1 RefSeqGene

      Range
      5034..53492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1160

    mRNA and Protein(s)

    1. NM_000617.3 → NP_000608.1  natural resistance-associated macrophage protein 2 isoform 3

      See identical proteins and their annotated locations for NP_000608.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus compared to isoform 1. Variants 4, 5 and 6 encode isoform 3.
      Source sequence(s)
      AB004857, BC100014, DA957633
      Consensus CDS
      CCDS8805.1
      UniProtKB/TrEMBL
      A0A2R8YD71
      Related
      ENSP00000262052.5, ENST00000262052.9
      Conserved Domains (2) summary
      TIGR01197
      Location:68 → 467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
      pfam01566
      Location:126 → 474
      Nramp; Natural resistance-associated macrophage protein

    2. NM_001174125.2 → NP_001167596.1  natural resistance-associated macrophage protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001167596.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC087884, AJ493662, BC002592
      Consensus CDS
      CCDS53793.1
      UniProtKB/TrEMBL
      A0A2R8YD71
      Related
      ENSP00000378364.3, ENST00000394904.9
      Conserved Domains (1) summary
      TIGR01197
      Location:97 → 496
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

    3. NM_001174126.2 → NP_001167597.1  natural resistance-associated macrophage protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001167597.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and in the 3' UTR and coding region compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Isoform 2 lacks the iron responsive element (IRE) found in isoform 1. Both variants 2 and 3 encode isoform 2.
      Source sequence(s)
      AC087884, AF064484, DB350334
      Consensus CDS
      CCDS53792.1
      UniProtKB/Swiss-Prot
      B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35
      UniProtKB/TrEMBL
      A0A0X8GKR4, A0A2R8YD71
      Related
      ENSP00000494107.1, ENST00000644495.1
      Conserved Domains (1) summary
      TIGR01197
      Location:68 → 467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

    4. NM_001174127.2 → NP_001167598.1  natural resistance-associated macrophage protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001167598.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and in the 3' UTR and coding region compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Isoform 2 lacks the iron responsive element (IRE) found in isoform 1. Both variants 2 and 3 encode isoform 2.
      Source sequence(s)
      AC087884
      Consensus CDS
      CCDS53792.1
      UniProtKB/Swiss-Prot
      B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35
      UniProtKB/TrEMBL
      A0A0X8GKR4, A0A2R8YD71
      Related
      ENSP00000446769.1, ENST00000547198.5
      Conserved Domains (1) summary
      TIGR01197
      Location:68 → 467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

    5. NM_001174128.2 → NP_001167599.1  natural resistance-associated macrophage protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001167599.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus compared to isoform 1. Variants 4, 5 and 6 encode isoform 3.
      Source sequence(s)
      AC087884, AF046997
      Consensus CDS
      CCDS8805.1
      UniProtKB/TrEMBL
      A0A2R8YD71
      Conserved Domains (2) summary
      TIGR01197
      Location:68 → 467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
      pfam01566
      Location:126 → 474
      Nramp; Natural resistance-associated macrophage protein

    6. NM_001174129.2 → NP_001167600.1  natural resistance-associated macrophage protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001167600.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus compared to isoform 1. Variants 4, 5 and 6 encode isoform 3.
      Source sequence(s)
      AC087884
      Consensus CDS
      CCDS8805.1
      UniProtKB/TrEMBL
      A0A2R8YD71
      Related
      ENSP00000444542.2, ENST00000541174.6
      Conserved Domains (2) summary
      TIGR01197
      Location:68 → 467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
      pfam01566
      Location:126 → 474
      Nramp; Natural resistance-associated macrophage protein

    7. NM_001174130.2 → NP_001167601.1  natural resistance-associated macrophage protein 2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC087884, AK316507, DC324894
      Consensus CDS
      CCDS53791.1
      UniProtKB/TrEMBL
      A0A2R8YD71
      Related
      ENSP00000442810.2, ENST00000545993.7
      Conserved Domains (2) summary
      TIGR01197
      Location:64 → 463
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
      pfam01566
      Location:122 → 470
      Nramp; Natural resistance-associated macrophage protein

    8. NM_001379446.1 → NP_001366375.1  natural resistance-associated macrophage protein 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Consensus CDS
      CCDS91695.1
      UniProtKB/TrEMBL
      A0A2R8YD71
      Related
      ENSP00000449200.2, ENST00000547688.7
      Conserved Domains (1) summary
      TIGR01197
      Location:97 → 496
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

    9. NM_001379447.2 → NP_001366376.1  natural resistance-associated macrophage protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Consensus CDS
      CCDS53792.1
      UniProtKB/Swiss-Prot
      B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35
      UniProtKB/TrEMBL
      A0A0X8GKR4, A0A2R8YD71
      Conserved Domains (1) summary
      TIGR01197
      Location:68 → 467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

    10. NM_001379448.1 → NP_001366377.1  natural resistance-associated macrophage protein 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC087884
      UniProtKB/TrEMBL
      A0A2R8YD71
      Conserved Domains (1) summary
      TIGR01197
      Location:64 → 463
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

    11. NM_001379455.1 → NP_001366384.1  natural resistance-associated macrophage protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Consensus CDS
      CCDS53793.1
      UniProtKB/TrEMBL
      A0A2R8YD71
      Conserved Domains (1) summary
      TIGR01197
      Location:97 → 496
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

    12. NM_001414744.1 → NP_001401673.1  natural resistance-associated macrophage protein 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC087884

    13. NM_001414745.1 → NP_001401674.1  natural resistance-associated macrophage protein 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC087884

    14. NM_001414746.1 → NP_001401675.1  natural resistance-associated macrophage protein 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Related
      ENSP00000493633.1, ENST00000643884.1

    15. NM_001414747.1 → NP_001401676.1  natural resistance-associated macrophage protein 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC087884

    16. NM_001414748.1 → NP_001401677.1  natural resistance-associated macrophage protein 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC087884

    17. NM_001414749.1 → NP_001401678.1  natural resistance-associated macrophage protein 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC087884
      UniProtKB/TrEMBL
      F8W1P7
      Related
      ENSP00000446914.1, ENST00000546743.5

    18. NM_001414750.1 → NP_001401679.1  natural resistance-associated macrophage protein 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC087884
      UniProtKB/TrEMBL
      F8W1P7

    RNA

    1. NR_033421.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) contains an alternate 5' exon and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC087884, AK315987, CK000292

    2. NR_033422.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) contains an alternate 5' exon and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC087884, CD365137

    3. NR_166668.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    4. NR_166669.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    5. NR_166670.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    6. NR_183175.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    7. NR_183176.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884
      Related
      ENST00000642227.1

    8. NR_183177.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    9. NR_183178.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    10. NR_183179.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087884

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      50952263..51028886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428887.1 → XP_047284843.1  natural resistance-associated macrophage protein 2 isoform X1

    2. XM_011538405.4 → XP_011536707.1  natural resistance-associated macrophage protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011536707.1

      UniProtKB/Swiss-Prot
      B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35
      UniProtKB/TrEMBL
      A0A0X8GKR4, A0A2R8YD71
      Conserved Domains (1) summary
      TIGR01197
      Location:68 → 467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

    3. XM_011538404.4 → XP_011536706.1  natural resistance-associated macrophage protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011536706.1

      UniProtKB/Swiss-Prot
      B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35
      UniProtKB/TrEMBL
      A0A0X8GKR4, A0A2R8YD71
      Conserved Domains (1) summary
      TIGR01197
      Location:68 → 467
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

    RNA

    1. XR_001748720.2 RNA Sequence

    2. XR_007063077.1 RNA Sequence

    3. XR_007063078.1 RNA Sequence

    4. XR_944555.2 RNA Sequence

    5. XR_429104.2 RNA Sequence

    6. XR_007063079.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      50915621..50992224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372124.1 → XP_054228099.1  natural resistance-associated macrophage protein 2 isoform X1

    2. XM_054372125.1 → XP_054228100.1  natural resistance-associated macrophage protein 2 isoform X2

      UniProtKB/Swiss-Prot
      B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35
      UniProtKB/TrEMBL
      A0A0X8GKR4

    3. XM_054372126.1 → XP_054228101.1  natural resistance-associated macrophage protein 2 isoform X2

      UniProtKB/Swiss-Prot
      B3KT08, B4DK84, F5H741, O43288, O60932, O94801, P49281, Q498Z5, Q8IUD7, Q96J35
      UniProtKB/TrEMBL
      A0A0X8GKR4

    RNA

    1. XR_008488592.1 RNA Sequence

    2. XR_008488591.1 RNA Sequence

    3. XR_008488590.1 RNA Sequence

    4. XR_008488593.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49281.2 GenPept UniProtKB/Swiss-Prot:P49281

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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