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    CDIN1 CDAN1 interacting nuclease 1 [ Homo sapiens (human) ]

    Gene ID: 84529, updated on 5-Mar-2024

    Summary

    Official Symbol
    CDIN1provided by HGNC
    Official Full Name
    CDAN1 interacting nuclease 1provided by HGNC
    Primary source
    HGNC:HGNC:26929
    See related
    Ensembl:ENSG00000186073 MIM:615626; AllianceGenome:HGNC:26929
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HH114; C15orf41
    Summary
    This gene encodes a protein with two predicted helix-turn-helix domains. Mutations in this gene were found in families with congenital dyserythropoietic anemia type Ib. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
    Expression
    Broad expression in heart (RPKM 18.6), urinary bladder (RPKM 3.9) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    15q14
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (36579626..36810244)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (34385147..34615722)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (36871827..37102445)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370770 Neighboring gene VISTA enhancer hs355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9193 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:36919333-36919834 Neighboring gene tropomyosin 3 pseudogene Neighboring gene Sharpr-MPRA regulatory region 1254 Neighboring gene LARP4 pseudogene Neighboring gene tyrosylprotein sulfotransferase 2 pseudogene 1 Neighboring gene uncharacterized LOC124903466 Neighboring gene VISTA enhancer hs828 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:37045234-37045802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9194 Neighboring gene casein kinase 1 alpha 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9195 Neighboring gene small nucleolar RNA U3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:37169875-37170652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:37170653-37171430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:37172643-37173204 Neighboring gene NANOG hESC enhancer GRCh37_chr15:37173676-37174246 Neighboring gene uncharacterized LOC145845

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ22851, MGC11326

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in erythrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    CDAN1-interacting nuclease 1
    Names
    protein C15orf41
    uncharacterized protein C15orf41

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034055.1 RefSeqGene

      Range
      5024..235642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130010.3NP_001123482.1  CDAN1-interacting nuclease 1 isoform 1

      See identical proteins and their annotated locations for NP_001123482.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AA581466, AL526474, BC006254, BX647650, DA467314
      Consensus CDS
      CCDS45215.1
      UniProtKB/Swiss-Prot
      B2RD87, Q9Y2V0
      Related
      ENSP00000401362.2, ENST00000437989.6
      Conserved Domains (1) summary
      pfam14811
      Location:135265
      TPD; Protein of unknown function TPD sequence-motif
    2. NM_001290232.2NP_001277161.1  CDAN1-interacting nuclease 1 isoform 2

      See identical proteins and their annotated locations for NP_001277161.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC013640, AC019016, AC103988, AK315446
      Consensus CDS
      CCDS45216.1
      UniProtKB/Swiss-Prot
      Q9Y2V0
      Related
      ENSP00000457854.1, ENST00000562877.5
      Conserved Domains (1) summary
      pfam14811
      Location:37167
      TPD; Protein of unknown function TPD sequence-motif
    3. NM_001290233.2NP_001277162.1  CDAN1-interacting nuclease 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks multiple 3' exons and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-temrinus and is longer than isoform 1.
      Source sequence(s)
      AC013640, AC103988, AK026504, BC006254
      Consensus CDS
      CCDS86445.1
      UniProtKB/TrEMBL
      A0A2R8YD89
      Related
      ENSP00000493669.1, ENST00000570265.6
      Conserved Domains (1) summary
      pfam14811
      Location:135241
      TPD; Protein of unknown function TPD sequence-motif
    4. NM_001321756.2NP_001308685.1  CDAN1-interacting nuclease 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC013640, AC019016, AC103988
      Consensus CDS
      CCDS45216.1
      UniProtKB/Swiss-Prot
      Q9Y2V0
      Conserved Domains (1) summary
      pfam14811
      Location:37167
      TPD; Protein of unknown function TPD sequence-motif
    5. NM_001321757.2NP_001308686.1  CDAN1-interacting nuclease 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC013640, AC019016, AC103988
      Consensus CDS
      CCDS86447.1
      UniProtKB/TrEMBL
      A0A2R8Y7J6
      Related
      ENSP00000496325.1, ENST00000643612.1
      Conserved Domains (1) summary
      pfam14811
      Location:12142
      TPD; Protein of unknown function TPD sequence-motif
    6. NM_001321758.2NP_001308687.1  CDAN1-interacting nuclease 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC013640, AC019016, AC103988
      Conserved Domains (1) summary
      pfam14811
      Location:98228
      TPD; Protein of unknown function TPD sequence-motif
    7. NM_001321759.2NP_001308688.1  CDAN1-interacting nuclease 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC013640, AC019016, AC103988
      Consensus CDS
      CCDS45215.1
      UniProtKB/Swiss-Prot
      B2RD87, Q9Y2V0
      Related
      ENSP00000455397.1, ENST00000566621.6
      Conserved Domains (1) summary
      pfam14811
      Location:135265
      TPD; Protein of unknown function TPD sequence-motif
    8. NM_001321760.2NP_001308689.1  CDAN1-interacting nuclease 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC013640, AC019016, AC103988
      Consensus CDS
      CCDS86446.1
      UniProtKB/TrEMBL
      A0A2R8YEZ2
      Related
      ENSP00000494718.1, ENST00000646533.1
      Conserved Domains (1) summary
      pfam14811
      Location:135203
      TPD; Protein of unknown function TPD sequence-motif
    9. NM_001321761.2NP_001308690.1  CDAN1-interacting nuclease 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC013640, AC019016, AC103988
      Consensus CDS
      CCDS81861.1
      UniProtKB/TrEMBL
      H3BS01
      Related
      ENSP00000456477.1, ENST00000569302.6
      Conserved Domains (1) summary
      pfam14811
      Location:135271
      TPD; Protein of unknown function TPD sequence-motif
    10. NM_032499.6NP_115888.1  CDAN1-interacting nuclease 1 isoform 2

      See identical proteins and their annotated locations for NP_115888.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' and 3' UTRs, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AA581466, AC013640, AC103988, AF114263, AL526474, BX647650, DA534917
      Consensus CDS
      CCDS45216.1
      UniProtKB/Swiss-Prot
      Q9Y2V0
      Related
      ENSP00000456736.1, ENST00000567389.5
      Conserved Domains (1) summary
      pfam14811
      Location:37167
      TPD; Protein of unknown function TPD sequence-motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      36579626..36810244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433174.1XP_047289130.1  CDAN1-interacting nuclease 1 isoform X4

    2. XM_017022676.2XP_016878165.1  CDAN1-interacting nuclease 1 isoform X1

      Conserved Domains (1) summary
      pfam14811
      Location:103199
      TPD; Protein of unknown function TPD sequence-motif
    3. XM_017022677.2XP_016878166.1  CDAN1-interacting nuclease 1 isoform X1

      Conserved Domains (1) summary
      pfam14811
      Location:103199
      TPD; Protein of unknown function TPD sequence-motif
    4. XM_047433171.1XP_047289127.1  CDAN1-interacting nuclease 1 isoform X2

    5. XM_047433172.1XP_047289128.1  CDAN1-interacting nuclease 1 isoform X3

    6. XM_047433173.1XP_047289129.1  CDAN1-interacting nuclease 1 isoform X3

    7. XM_047433175.1XP_047289131.1  CDAN1-interacting nuclease 1 isoform X5

    8. XM_047433176.1XP_047289132.1  CDAN1-interacting nuclease 1 isoform X6

      UniProtKB/TrEMBL
      A0A2R8Y7J6

    RNA

    1. XR_007064491.1 RNA Sequence

    2. XR_007064492.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      34385147..34615722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378997.1XP_054234972.1  CDAN1-interacting nuclease 1 isoform X4

    2. XM_054378995.1XP_054234970.1  CDAN1-interacting nuclease 1 isoform X1

    3. XM_054378996.1XP_054234971.1  CDAN1-interacting nuclease 1 isoform X1

    4. XM_054378998.1XP_054234973.1  CDAN1-interacting nuclease 1 isoform X6

      UniProtKB/TrEMBL
      A0A2R8Y7J6

    RNA

    1. XR_008489019.1 RNA Sequence

    2. XR_008489020.1 RNA Sequence

    3. XR_008489021.1 RNA Sequence

    4. XR_008489022.1 RNA Sequence

    5. XR_008489023.1 RNA Sequence

    6. XR_008489024.1 RNA Sequence