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    KRT6C keratin 6C [ Homo sapiens (human) ]

    Gene ID: 286887, updated on 7-Apr-2024

    Summary

    Official Symbol
    KRT6Cprovided by HGNC
    Official Full Name
    keratin 6Cprovided by HGNC
    Primary source
    HGNC:HGNC:20406
    See related
    Ensembl:ENSG00000170465 MIM:612315; AllianceGenome:HGNC:20406
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K6E; KRT6E; PPKNEFD
    Summary
    Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jul 2009]
    Expression
    Restricted expression toward esophagus (RPKM 948.5) See more
    Orthologs
    NEW
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    Genomic context

    Location:
    12q13.13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (52468516..52473805, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (52433115..52438404, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52862300..52867589, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 75 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52831010-52831512 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:52835896-52837095 Neighboring gene keratin 6B Neighboring gene keratin 6A Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:52909857-52911056 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:52912066-52913265 Neighboring gene keratin 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102925, MGC163455, MGC163457

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in intermediate filament cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in intermediate filament NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    keratin, type II cytoskeletal 6C
    Names
    CK-6C
    CK-6E
    K6C
    cytokeratin-6C
    cytokeratin-6E
    keratin 6C, type II
    keratin 6E
    keratin K6h
    type-II keratin Kb12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012416.1 RefSeqGene

      Range
      4981..10270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_173086.5NP_775109.2  keratin, type II cytoskeletal 6C

      See identical proteins and their annotated locations for NP_775109.2

      Status: REVIEWED

      Source sequence(s)
      AC055736, BC110639
      Consensus CDS
      CCDS8829.1
      UniProtKB/Swiss-Prot
      A1L4L5, P48666, P48668, Q2TAZ9, Q7RTN9
      UniProtKB/TrEMBL
      B2R853
      Related
      ENSP00000252250.6, ENST00000252250.7
      Conserved Domains (2) summary
      pfam00038
      Location:162475
      Filament; Intermediate filament protein
      pfam16208
      Location:17159
      Keratin_2_head; Keratin type II head

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      52468516..52473805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      52433115..52438404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)