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    CANT1 calcium activated nucleotidase 1 [ Homo sapiens (human) ]

    Gene ID: 124583, updated on 17-Jun-2024

    Summary

    Official Symbol
    CANT1provided by HGNC
    Official Full Name
    calcium activated nucleotidase 1provided by HGNC
    Primary source
    HGNC:HGNC:19721
    See related
    Ensembl:ENSG00000171302 MIM:613165; AllianceGenome:HGNC:19721
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DBQD; EDM7; DBQD1; SCAN1; SHAPY; SCAN-1
    Summary
    This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.[provided by RefSeq, Mar 2010]
    Expression
    Broad expression in colon (RPKM 44.8), prostate (RPKM 33.6) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CANT1 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (78991716..79009764, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79886485..79904693, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76987798..77005846, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TIMP metallopeptidase inhibitor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76898462-76899062 Neighboring gene CEP295 N-terminal like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76911943-76912638 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76912639-76913334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76914785-76915760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12914 Neighboring gene Sharpr-MPRA regulatory region 14803 Neighboring gene Sharpr-MPRA regulatory region 6708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76972258-76972941 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76976039-76977031 Neighboring gene galectin 3 binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12915 Neighboring gene C1QTNF1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9078 Neighboring gene C1q and TNF related 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77040047-77040547 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:77042736-77043935 Neighboring gene Sharpr-MPRA regulatory region 5335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9079 Neighboring gene endo-beta-N-acetylglucosaminidase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of calcium activated nucleotidase 1 (CANT1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in specific granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in tertiary granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    soluble calcium-activated nucleotidase 1
    Names
    Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase
    apyrase 1 homolog (C. lectularius)
    apyrase homolog
    micromelic dwarfism with vertebral and metaphyseal abnormalities and advanced carpotarsal ossification
    putative MAPK-activating protein PM09
    putative NF-kappa-B-activating protein 107
    soluble Ca-activated nucleotidase, isozyme 1
    soluble calcium-activated nucleotidase SCAN-1
    NP_001153244.1
    NP_001153245.1
    NP_620148.1
    XP_054170966.1
    XP_054170967.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016645.1 RefSeqGene

      Range
      5054..23102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001159772.2NP_001153244.1  soluble calcium-activated nucleotidase 1

      See identical proteins and their annotated locations for NP_001153244.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AF328554, BC017655
      Consensus CDS
      CCDS11760.1
      UniProtKB/Swiss-Prot
      B4DJ54, Q7Z2J7, Q8NG05, Q8NHP0, Q8WVQ1, Q9BSD5
      Related
      ENSP00000467437.1, ENST00000591773.5
      Conserved Domains (1) summary
      pfam06079
      Location:113400
      Apyrase; Apyrase
    2. NM_001159773.2NP_001153245.1  soluble calcium-activated nucleotidase 1

      See identical proteins and their annotated locations for NP_001153245.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC017655, DC355691
      Consensus CDS
      CCDS11760.1
      UniProtKB/Swiss-Prot
      B4DJ54, Q7Z2J7, Q8NG05, Q8NHP0, Q8WVQ1, Q9BSD5
      Related
      ENSP00000376241.4, ENST00000392446.10
      Conserved Domains (1) summary
      pfam06079
      Location:113400
      Apyrase; Apyrase
    3. NM_138793.4NP_620148.1  soluble calcium-activated nucleotidase 1

      See identical proteins and their annotated locations for NP_620148.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK074687, BC017655, DC355691
      Consensus CDS
      CCDS11760.1
      UniProtKB/Swiss-Prot
      B4DJ54, Q7Z2J7, Q8NG05, Q8NHP0, Q8WVQ1, Q9BSD5
      Related
      ENSP00000307674.2, ENST00000302345.6
      Conserved Domains (1) summary
      pfam06079
      Location:113400
      Apyrase; Apyrase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      78991716..79009764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      79886485..79904693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314992.1XP_054170967.1  soluble calcium-activated nucleotidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DJ54, Q7Z2J7, Q8NG05, Q8NHP0, Q8WVQ1, Q9BSD5
    2. XM_054314991.1XP_054170966.1  soluble calcium-activated nucleotidase 1 isoform X1

      UniProtKB/Swiss-Prot
      B4DJ54, Q7Z2J7, Q8NG05, Q8NHP0, Q8WVQ1, Q9BSD5