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    PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 [ Homo sapiens (human) ]

    Gene ID: 5296, updated on 23-Nov-2023

    Summary

    Official Symbol
    PIK3R2provided by HGNC
    Official Full Name
    phosphoinositide-3-kinase regulatory subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:8980
    See related
    Ensembl:ENSG00000105647 MIM:603157; AllianceGenome:HGNC:8980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p85; MPPH; P85B; MPPH1; p85beta; p85-BETA
    Summary
    Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Three transcript variants, one protein coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Apr 2019]
    Expression
    Ubiquitous expression in brain (RPKM 16.0), skin (RPKM 12.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PIK3R2 in Genome Data Viewer
    Location:
    19p13.11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (18153163..18170532)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (18287263..18304664)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18263973..18281342)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12288 Neighboring gene interleukin 12 receptor subunit beta 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10368 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10369 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18220925-18221494 Neighboring gene microtubule associated serine/threonine kinase 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18228711-18229582 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:18232970-18234169 Neighboring gene uncharacterized LOC124904650 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18256091-18256592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18256593-18257093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14300 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18263346-18264238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18267436-18268294 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:18270202-18270406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18271190-18271739 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14303 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18285185-18285850 Neighboring gene IFI30 lysosomal thiol reductase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14305 Neighboring gene MPV17 mitochondrial inner membrane protein like 2 Neighboring gene RAB3A, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1
    MedGen: C4012727 OMIM: 603387 GeneReviews: MPPH Syndrome
    Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2015-06-25)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2015-06-25)

    ClinGen Genome Curation Page

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes PubMed
    env CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn PubMed
    env Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production PubMed
    env Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling PubMed
    env CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway PubMed
    env HIV-1 gp120 induces an increase in tyrosine phosphorylation of two proteins, p56lck and phosphatidylinositol 3-kinase (PI 3-kinase) p85 alpha, that are physically complexed to the CD4 molecule PubMed
    env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
    env HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors PubMed
    env HIV-1 gp120-induced TNF-alpha production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 disrupts the association between phospholipase C gamma-1 and phosphoinositide 3 kinase (PI3-kinase), and this effect is dependent on PI3-kinase activity PubMed
    env PI3-kinase activation induced by HIV-1 gp160 leads to downregulation of LFA-1-mediated T cell adhesion to B cells PubMed
    Nef nef HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells PubMed
    nef Diaminoquinoxaline benzenesulfonamide (DQBS) treatment reduces the amount of both HCK and the p85 regulatory subunit of PI3K associated with HIV-1 Nef and completely blocks Nef-dependent activation of ZAP-70 PubMed
    nef Downregulation of cell surface major histocompatibility complex class I (MHC-I) protein expression by HIV-1 Nef depends on a phosphoinositide 3-kinase (PI3K)-regulated signaling pathway, suggesting an interaction between Nef and PI3K PubMed
    nef In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase PubMed
    nef The presence of HIV-1 Nef in Jurkat cells stimulated with a combination of PMA and anti-CD28 upregulates the levels of PI3K production PubMed
    nef The association of phosphatidylinositol (PI) 3-kinase with platelet-derived growth factor (PDGF) activated receptor was downregulated by HIV-1 nef expression PubMed
    Tat tat HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells PubMed
    tat HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells PubMed
    tat Arctigenin regulates the upstream PI3K enzyme from converting PIP2 to PIP3 in Tat-expressing CHME5 cells PubMed
    tat HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells PubMed
    tat HIV-1 Tat-mediated cytopathic changes in human brain micro vascular endothelial cells involves its interaction with phosphatidylinositol 3-kinase (PI3K) PubMed
    tat Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway PubMed
    tat HIV-1 Tat activates phosphatidylinositol 3-kinase (PI3K), leading to the activation of Akt/PKB, decreased levels of cAMP and CREB phosphorylation, and the protection of cells from apoptosis PubMed
    tat Phosphatidylinositol 3-kinase inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter by affecting the formation of the Tat-associated kinase transactivating complex PubMed
    tat HIV-1 Tat induced release of MCP-1 from human lung microvascular endothelial cells involves an interaction between Tat and PI3 kinase PubMed
    tat Activation of protein kinase C-epsilon by HIV-1 Tat involves an interaction with PI 3-kinase PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: IFI30

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol 3-kinase regulatory subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotyrosine residue binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in T cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein import into nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of phosphatidylinositol 3-kinase complex, class IA IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IA NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    phosphatidylinositol 3-kinase regulatory subunit beta
    Names
    PI3-kinase subunit p85-beta
    PI3K regulatory subunit beta
    phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta
    phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
    phosphoinositide-3-kinase regulatory subunit beta
    phosphoinositide-3-kinase, regulatory subunit 2 (beta)
    ptdIns-3-kinase regulatory subunit p85-beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033010.2 RefSeqGene

      Range
      4986..22355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1392

    mRNA and Protein(s)

    1. NM_005027.4NP_005018.2  phosphatidylinositol 3-kinase regulatory subunit beta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the protein-coding variant.
      Source sequence(s)
      AC007192
      Consensus CDS
      CCDS12371.1
      UniProtKB/Swiss-Prot
      O00459, Q5EAT5, Q9UPH9
      Related
      ENSP00000222254.6, ENST00000222254.13
      Conserved Domains (5) summary
      cd09930
      Location:615717
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:322432
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd11909
      Location:780
      SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
      cd12926
      Location:437597
      iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
      cl02570
      Location:110296
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    RNA

    1. NR_073517.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC007192
      Related
      ENST00000426902.5
    2. NR_162071.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007192
      Related
      ENST00000617130.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      18153163..18170532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      18287263..18304664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)