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    DNMT3A DNA methyltransferase 3 alpha [ Homo sapiens (human) ]

    Gene ID: 1788, updated on 22-Apr-2024

    Summary

    Official Symbol
    DNMT3Aprovided by HGNC
    Official Full Name
    DNA methyltransferase 3 alphaprovided by HGNC
    Primary source
    HGNC:HGNC:2978
    See related
    Ensembl:ENSG00000119772 MIM:602769; AllianceGenome:HGNC:2978
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TBRS; HESJAS; DNMT3A2; M.HsaIIIA
    Summary
    CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in placenta (RPKM 5.8), ovary (RPKM 3.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    2p23.3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (25227874..25342590, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (25263222..25377928, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (25450743..25565459, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25383210-25384066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11245 Neighboring gene POMC promoter region Neighboring gene POMC distal enhancer region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11246 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25439263-25439780 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11247 Neighboring gene proopiomelanocortin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15444 Neighboring gene long intergenic non-protein coding RNA 1381 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25452372-25453102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25469436-25469945 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25470965-25471472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11249 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25476274-25476808 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25482555-25483258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25486869-25487452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25487453-25488037 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25492834-25493424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25495919-25496419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15445 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25499151-25499742 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25500333-25500922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25500923-25501512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15446 Neighboring gene Sharpr-MPRA regulatory region 14395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25519631-25520132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25528967-25529467 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25528466-25528966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25531317-25531818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25531819-25532318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25535893-25536656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:25536657-25537420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25544961-25545788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25552894-25553394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25553395-25553895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25557143-25557814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11253 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25578935-25579435 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:25581309-25581844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15450 Neighboring gene microRNA 1301 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 2:25596509 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15455 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15456 Neighboring gene uncharacterized LOC124900608 Neighboring gene dystrobrevin beta Neighboring gene DTNB antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2018-04-29)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2018-04-29)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.
    EBI GWAS Catalog
    A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates DNMT1, DNMT3A, and DNMT3B both at the mRNA and protein levels in primary tumors PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA (cytosine-5-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA (cytosine-5-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding EXP
    Inferred from Experiment
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-cysteine methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription corepressor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables unmethylated CpG binding EXP
    Inferred from Experiment
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA methylation-dependent heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in S-adenosylmethionine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in autosome genomic imprinting IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to bisphenol A IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epigenetic programming of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hepatocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of gene expression via chromosomal CpG island methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lead ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to vitamin A IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in XY body IEA
    Inferred from Electronic Annotation
    more info
     
    part_of catalytic complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of heterochromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA (cytosine-5)-methyltransferase 3A
    Names
    DNA (cytosine-5-)-methyltransferase 3 alpha
    DNA MTase HsaIIIA
    DNA cytosine methyltransferase 3A2
    cysteine methyltransferase DNMT3A
    NP_001307821.1
    NP_001307822.1
    NP_001362748.1
    NP_072046.2
    NP_715640.2
    NP_783328.1
    NP_783329.1
    XP_005264232.1
    XP_011530964.1
    XP_011530966.1
    XP_011530968.1
    XP_011530969.1
    XP_016859015.1
    XP_016859016.1
    XP_047299548.1
    XP_047299549.1
    XP_047299550.1
    XP_047299552.1
    XP_047299553.1
    XP_047299554.1
    XP_047299555.1
    XP_054196875.1
    XP_054196876.1
    XP_054196877.1
    XP_054196878.1
    XP_054196879.1
    XP_054196880.1
    XP_054196881.1
    XP_054196882.1
    XP_054196883.1
    XP_054196884.1
    XP_054196885.1
    XP_054196886.1
    XP_054196887.1
    XP_054196888.1
    XP_054196889.1
    XP_054196890.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029465.2 RefSeqGene

      Range
      5001..114630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_459

    mRNA and Protein(s)

    1. NM_001320892.2NP_001307821.1  DNA (cytosine-5)-methyltransferase 3A isoform c

      Status: REVIEWED

      Source sequence(s)
      AC012074, AL543971, BC032392, BC043617
      Consensus CDS
      CCDS46232.1
      UniProtKB/Swiss-Prot
      Q9Y6K1
      Conserved Domains (1) summary
      PTZ00449
      Location:482
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    2. NM_001320893.1NP_001307822.1  DNA (cytosine-5)-methyltransferase 3A isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses a downstream promoter compared to variants 1, 3, 4 and 7.
      Source sequence(s)
      AB208833, AC012074, AF480163, AI376254
      UniProtKB/Swiss-Prot
      Q9Y6K1
      UniProtKB/TrEMBL
      Q59HC6
      Conserved Domains (4) summary
      cd05835
      Location:138224
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:480643
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      PRK07003
      Location:30130
      PRK07003; DNA polymerase III subunit gamma/tau
      cd11729
      Location:335462
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
    3. NM_001375819.1NP_001362748.1  DNA (cytosine-5)-methyltransferase 3A isoform e

      Status: REVIEWED

      Source sequence(s)
      AC012074
      Consensus CDS
      CCDS92718.1
      UniProtKB/TrEMBL
      A0A0C4DG02
      Related
      ENSP00000384237.1, ENST00000402667.1
      Conserved Domains (3) summary
      cd05835
      Location:67153
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      cd11729
      Location:264391
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
      cl30459
      Location:409572
      Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
    4. NM_022552.5NP_072046.2  DNA (cytosine-5)-methyltransferase 3A isoform a

      See identical proteins and their annotated locations for NP_072046.2

      Status: REVIEWED

      Source sequence(s)
      AC012074
      Consensus CDS
      CCDS33157.1
      UniProtKB/Swiss-Prot
      E9PEB8, Q86TE8, Q86XF5, Q8IZV0, Q8WXU9, Q9Y6K1
      UniProtKB/TrEMBL
      Q59HC6
      Related
      ENSP00000324375.5, ENST00000321117.10
      Conserved Domains (4) summary
      cd05835
      Location:290376
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:632795
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11729
      Location:487614
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
      cl25756
      Location:11156
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    5. NM_153759.3NP_715640.2  DNA (cytosine-5)-methyltransferase 3A isoform b

      See identical proteins and their annotated locations for NP_715640.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a downstream promoter compared to variants 1, 3, 4, and 7.
      Source sequence(s)
      AF331856, AF480163, AI376254, BM470515
      Consensus CDS
      CCDS1718.2
      UniProtKB/Swiss-Prot
      Q9Y6K1
      Related
      ENSP00000370122.4, ENST00000380746.8
      Conserved Domains (3) summary
      cd05835
      Location:101187
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:443606
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11729
      Location:298425
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
    6. NM_175629.2NP_783328.1  DNA (cytosine-5)-methyltransferase 3A isoform a

      See identical proteins and their annotated locations for NP_783328.1

      Status: REVIEWED

      Source sequence(s)
      AF331856, AI376254, BC032392
      Consensus CDS
      CCDS33157.1
      UniProtKB/Swiss-Prot
      E9PEB8, Q86TE8, Q86XF5, Q8IZV0, Q8WXU9, Q9Y6K1
      UniProtKB/TrEMBL
      Q59HC6
      Related
      ENSP00000264709.3, ENST00000264709.7
      Conserved Domains (4) summary
      cd05835
      Location:290376
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:632795
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11729
      Location:487614
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
      cl25756
      Location:11156
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    7. NM_175630.1NP_783329.1  DNA (cytosine-5)-methyltransferase 3A isoform c

      See identical proteins and their annotated locations for NP_783329.1

      Status: REVIEWED

      Source sequence(s)
      BC032392
      Consensus CDS
      CCDS46232.1
      UniProtKB/Swiss-Prot
      Q9Y6K1
      Related
      ENSP00000384852.3, ENST00000406659.3

    RNA

    1. NR_135490.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB208833, AC012074, AI376254

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      25227874..25342590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264175.6XP_005264232.1  DNA (cytosine-5)-methyltransferase 3A isoform X1

      See identical proteins and their annotated locations for XP_005264232.1

      UniProtKB/Swiss-Prot
      E9PEB8, Q86TE8, Q86XF5, Q8IZV0, Q8WXU9, Q9Y6K1
      UniProtKB/TrEMBL
      Q59HC6
      Conserved Domains (4) summary
      cd05835
      Location:290376
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:632795
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11729
      Location:487614
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
      cl25756
      Location:11156
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    2. XM_017003526.2XP_016859015.1  DNA (cytosine-5)-methyltransferase 3A isoform X1

      UniProtKB/Swiss-Prot
      E9PEB8, Q86TE8, Q86XF5, Q8IZV0, Q8WXU9, Q9Y6K1
      UniProtKB/TrEMBL
      Q59HC6
      Conserved Domains (4) summary
      cd05835
      Location:290376
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:632795
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11729
      Location:487614
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
      cl25756
      Location:11156
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    3. XM_011532662.3XP_011530964.1  DNA (cytosine-5)-methyltransferase 3A isoform X2

      UniProtKB/TrEMBL
      Q59HC6
      Conserved Domains (3) summary
      cd05835
      Location:241327
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:583746
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11729
      Location:438565
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
    4. XM_047443592.1XP_047299548.1  DNA (cytosine-5)-methyltransferase 3A isoform X3

    5. XM_047443594.1XP_047299550.1  DNA (cytosine-5)-methyltransferase 3A isoform X7

    6. XM_011532667.4XP_011530969.1  DNA (cytosine-5)-methyltransferase 3A isoform X8

      See identical proteins and their annotated locations for XP_011530969.1

      UniProtKB/TrEMBL
      A0A0C4DG02
      Conserved Domains (3) summary
      cd05835
      Location:67153
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      cd11729
      Location:264391
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
      cl30459
      Location:409572
      Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
    7. XM_017003527.2XP_016859016.1  DNA (cytosine-5)-methyltransferase 3A isoform X8

      UniProtKB/TrEMBL
      A0A0C4DG02
      Conserved Domains (3) summary
      cd05835
      Location:67153
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      cd11729
      Location:264391
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
      cl30459
      Location:409572
      Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
    8. XM_047443598.1XP_047299554.1  DNA (cytosine-5)-methyltransferase 3A isoform X8

      UniProtKB/TrEMBL
      A0A0C4DG02
    9. XM_011532666.3XP_011530968.1  DNA (cytosine-5)-methyltransferase 3A isoform X6

      See identical proteins and their annotated locations for XP_011530968.1

      Conserved Domains (3) summary
      cd05835
      Location:114200
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:456619
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11729
      Location:311438
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
    10. XM_047443596.1XP_047299552.1  DNA (cytosine-5)-methyltransferase 3A isoform X8

      UniProtKB/TrEMBL
      A0A0C4DG02
    11. XM_047443597.1XP_047299553.1  DNA (cytosine-5)-methyltransferase 3A isoform X8

      UniProtKB/TrEMBL
      A0A0C4DG02
    12. XM_047443593.1XP_047299549.1  DNA (cytosine-5)-methyltransferase 3A isoform X4

    13. XM_011532664.3XP_011530966.1  DNA (cytosine-5)-methyltransferase 3A isoform X5

      See identical proteins and their annotated locations for XP_011530966.1

      UniProtKB/TrEMBL
      F8WE91, Q59HC6
      Related
      ENSP00000370132.3, ENST00000380756.7
      Conserved Domains (3) summary
      cd05835
      Location:290376
      Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
      COG0270
      Location:632781
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd11729
      Location:487614
      ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)
    14. XM_047443599.1XP_047299555.1  DNA (cytosine-5)-methyltransferase 3A isoform X9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      25263222..25377928 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340901.1XP_054196876.1  DNA (cytosine-5)-methyltransferase 3A isoform X1

      UniProtKB/Swiss-Prot
      E9PEB8, Q86TE8, Q86XF5, Q8IZV0, Q8WXU9, Q9Y6K1
    2. XM_054340900.1XP_054196875.1  DNA (cytosine-5)-methyltransferase 3A isoform X1

      UniProtKB/Swiss-Prot
      E9PEB8, Q86TE8, Q86XF5, Q8IZV0, Q8WXU9, Q9Y6K1
    3. XM_054340902.1XP_054196877.1  DNA (cytosine-5)-methyltransferase 3A isoform X2

    4. XM_054340903.1XP_054196878.1  DNA (cytosine-5)-methyltransferase 3A isoform X3

    5. XM_054340909.1XP_054196884.1  DNA (cytosine-5)-methyltransferase 3A isoform X7

    6. XM_054340910.1XP_054196885.1  DNA (cytosine-5)-methyltransferase 3A isoform X8

      UniProtKB/TrEMBL
      A0A0C4DG02
    7. XM_054340913.1XP_054196888.1  DNA (cytosine-5)-methyltransferase 3A isoform X8

      UniProtKB/TrEMBL
      A0A0C4DG02
    8. XM_054340908.1XP_054196883.1  DNA (cytosine-5)-methyltransferase 3A isoform X6

    9. XM_054340911.1XP_054196886.1  DNA (cytosine-5)-methyltransferase 3A isoform X8

      UniProtKB/TrEMBL
      A0A0C4DG02
    10. XM_054340912.1XP_054196887.1  DNA (cytosine-5)-methyltransferase 3A isoform X8

      UniProtKB/TrEMBL
      A0A0C4DG02
    11. XM_054340907.1XP_054196882.1  DNA (cytosine-5)-methyltransferase 3A isoform X11

    12. XM_054340906.1XP_054196881.1  DNA (cytosine-5)-methyltransferase 3A isoform X10

    13. XM_054340904.1XP_054196879.1  DNA (cytosine-5)-methyltransferase 3A isoform X4

    14. XM_054340915.1XP_054196890.1  DNA (cytosine-5)-methyltransferase 3A isoform X5

      UniProtKB/TrEMBL
      F8WE91
    15. XM_054340905.1XP_054196880.1  DNA (cytosine-5)-methyltransferase 3A isoform X5

      UniProtKB/TrEMBL
      F8WE91
    16. XM_054340914.1XP_054196889.1  DNA (cytosine-5)-methyltransferase 3A isoform X9