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    SLC16A1 solute carrier family 16 member 1 [ Homo sapiens (human) ]

    Gene ID: 6566, updated on 5-May-2024

    Summary

    Official Symbol
    SLC16A1provided by HGNC
    Official Full Name
    solute carrier family 16 member 1provided by HGNC
    Primary source
    HGNC:HGNC:10922
    See related
    Ensembl:ENSG00000155380 MIM:600682; AllianceGenome:HGNC:10922
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCT; HHF7; MCT1; MCT1D
    Summary
    The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]
    Expression
    Broad expression in heart (RPKM 23.3), colon (RPKM 22.1) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    1p13.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (112911847..112956196, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (112924405..112968780, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113454469..113498818, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 11399 Neighboring gene uncharacterized LOC124904342 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:113440206-113440749 Neighboring gene ribosomal protein L39 pseudogene 8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113444917-113445850 Neighboring gene Sharpr-MPRA regulatory region 4510 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113448786-113449345 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113453686-113454297 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113454298-113454908 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113465491-113466356 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113466357-113467221 Neighboring gene AKR7A2 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113486444-113486944 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113497825-113498414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1207 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:113499595-113500183 Neighboring gene SLC16A1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113511652-113512152 Neighboring gene uncharacterized LOC107985189

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ36745, MGC44475

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carboxylic acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lactate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables lactate transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables lactate:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lactate:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mevalonate transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables monocarboxylic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables monocarboxylic acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables organic cyclic compound binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables succinate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in behavioral response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in carboxylic acid transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mevalonate transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in monocarboxylic acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in monocarboxylic acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in plasma membrane lactate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in plasma membrane lactate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in plasma membrane lactate transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pyruvate catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pyruvate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to food IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in succinate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transport across blood-brain barrier NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    monocarboxylate transporter 1
    Names
    MCT 1
    solute carrier family 16 (monocarboxylate transporter), member 1
    solute carrier family 16 (monocarboxylic acid transporters), member 1
    solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015880.2 RefSeqGene

      Range
      4733..49082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001166496.2NP_001159968.1  monocarboxylate transporter 1

      See identical proteins and their annotated locations for NP_001159968.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI656300, AK094064, AK296688, AL158844, AL162079, BC026317, BP294493
      Consensus CDS
      CCDS858.1
      UniProtKB/Swiss-Prot
      P53985, Q49A45, Q5T8R6, Q9NSJ9
      UniProtKB/TrEMBL
      B2R6A5
      Related
      ENSP00000441065.1, ENST00000538576.5
      Conserved Domains (1) summary
      TIGR00892
      Location:1455
      2A0113; monocarboxylate transporter 1
    2. NM_003051.4NP_003042.3  monocarboxylate transporter 1

      See identical proteins and their annotated locations for NP_003042.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL158844
      Consensus CDS
      CCDS858.1
      UniProtKB/Swiss-Prot
      P53985, Q49A45, Q5T8R6, Q9NSJ9
      UniProtKB/TrEMBL
      B2R6A5
      Related
      ENSP00000358640.4, ENST00000369626.8
      Conserved Domains (1) summary
      TIGR00892
      Location:1455
      2A0113; monocarboxylate transporter 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      112911847..112956196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428789.1XP_047284745.1  monocarboxylate transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      P53985, Q49A45, Q5T8R6, Q9NSJ9
      Related
      ENSP00000399104.2, ENST00000443580.6

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646196.1 Reference GRCh38.p14 PATCHES

      Range
      2426..46775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331540.1XP_054187515.1  monocarboxylate transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      P53985, Q49A45, Q5T8R6, Q9NSJ9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      112924405..112968780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338454.1XP_054194429.1  monocarboxylate transporter 1 isoform X1