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    CREB3L1 cAMP responsive element binding protein 3 like 1 [ Homo sapiens (human) ]

    Gene ID: 90993, updated on 25-Jan-2024

    Summary

    Official Symbol
    CREB3L1provided by HGNC
    Official Full Name
    cAMP responsive element binding protein 3 like 1provided by HGNC
    Primary source
    HGNC:HGNC:18856
    See related
    Ensembl:ENSG00000157613 MIM:616215; AllianceGenome:HGNC:18856
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OI16; OASIS; DEL16p11.2; C16DELp11.2
    Summary
    The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]
    Expression
    Broad expression in stomach (RPKM 29.2), colon (RPKM 23.7) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CREB3L1 in Genome Data Viewer
    Location:
    11p11.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (46277662..46321409)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (46433747..46477484)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (46299213..46342959)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3299 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr11:46263977-46264910 and GRCh37_chr11:46264911-46265844 Neighboring gene CRISPRi-validated cis-regulatory element chr11.2129 Neighboring gene long intergenic non-protein coding RNA 2489 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46312695-46313398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3301 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:46328063-46328758 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:46352624-46352765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46357769-46358498 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46360689-46361418 Neighboring gene Sharpr-MPRA regulatory region 11965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3303 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:46369312-46369525 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46369839-46370824 Neighboring gene diacylglycerol kinase zeta Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46373336-46374190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46374191-46375045 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46375046-46375899 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46377222-46378090 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:46390736-46391935 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:46401950-46402584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3306 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3307 Neighboring gene Sharpr-MPRA regulatory region 2210 Neighboring gene microRNA 4688 Neighboring gene cholinergic receptor muscarinic 4 Neighboring gene midkine

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cAMP response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cAMP response element binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in extracellular matrix constituent secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of sprouting angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of collagen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cyclic AMP-responsive element-binding protein 3-like protein 1
    Names
    BBF-2 homolog
    Osteogenesis imperfecta, type XVI
    cAMP-responsive element-binding protein 3-like protein 1
    old astrocyte specifically-induced substance

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033264.2 RefSeqGene

      Range
      5002..48749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001425266.1NP_001412195.1  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC116021, KF459675
      UniProtKB/TrEMBL
      B2RA75
    2. NM_001425267.1NP_001412196.1  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC116021, KF459675
      UniProtKB/TrEMBL
      B2RA75
    3. NM_001425268.1NP_001412197.1  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC116021, KF459675
      UniProtKB/TrEMBL
      B2RA75
    4. NM_001425269.1NP_001412198.1  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC116021, KF459675
      UniProtKB/TrEMBL
      B2RA75
    5. NM_052854.4NP_443086.1  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_443086.1

      Status: REVIEWED

      Source sequence(s)
      AC116021, AK314072, BC015781, CF131922
      Consensus CDS
      CCDS53620.1
      UniProtKB/Swiss-Prot
      Q8N2D5, Q96BA8, Q96CP0
      UniProtKB/TrEMBL
      B2RA75
      Related
      ENSP00000481956.1, ENST00000621158.5
      Conserved Domains (1) summary
      cd14689
      Location:291344
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    RNA

    1. NR_189153.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC116021, KF459675

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      46277662..46321409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006718380.4XP_006718443.1  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1

      Conserved Domains (1) summary
      cd14689
      Location:291343
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      46433747..46477484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370466.1XP_054226441.1  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1