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    MTOR mechanistic target of rapamycin kinase [ Homo sapiens (human) ]

    Gene ID: 2475, updated on 19-Feb-2024

    Summary

    Official Symbol
    MTORprovided by HGNC
    Official Full Name
    mechanistic target of rapamycin kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:3942
    See related
    Ensembl:ENSG00000198793 MIM:601231; AllianceGenome:HGNC:3942
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SKS; FRAP; FRAP1; FRAP2; RAFT1; RAPT1
    Summary
    The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 treatment.
    Expression
    Broad expression in testis (RPKM 23.6), brain (RPKM 8.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MTOR in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (11106535..11262551, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (10648106..10804142, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11166592..11322608, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 163 Neighboring gene exosome component 10 Neighboring gene spermidine synthase Neighboring gene ReSE screen-validated silencer GRCh37_chr1:11152350-11152530 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11159092-11159654 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11159655-11160215 Neighboring gene EXOSC10 antisense RNA 1 Neighboring gene MTOR antisense RNA 1 Neighboring gene RNA, U6 small nuclear 537, pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr1:11237905-11238443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11249765-11250265 Neighboring gene MPRA-validated peak73 silencer Neighboring gene angiopoietin like 7 Neighboring gene RNA, U6 small nuclear 291, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:11301605-11302164 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:11308472-11309038 Neighboring gene ribosomal protein L39 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 167 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:11349216-11349398 Neighboring gene ubiquitin conjugating enzyme E2 V2 pseudogene 3 Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:11365397-11366222 Neighboring gene uncharacterized LOC105376737

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Isolated focal cortical dysplasia type II
    MedGen: C1846385 OMIM: 607341 GeneReviews: Not available
    Compare labs
    Macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome
    MedGen: C4225259 OMIM: 616638 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.
    EBI GWAS Catalog
    CMPK1 and RBP3 are associated with corneal curvature in Asian populations.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Syncytia arising from the fusion of cells expressing HIV-1 gp120 with cells expressing the CD4/CXCR4 complex causes phosphorylation of p53, which is mediated by the upregulation of mammalian target of FKBP12-rapamycin-associated protein (FRAP) PubMed
    Nef nef HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells PubMed
    Tat tat HIV-1 Tat induces phosphorylation of mTOR in Tat-expressing cells and HIV-1-infected cells PubMed
    capsid gag Treatment with Torin 1, mTOR kinase inhibitor, significantly downregulates HIV-1 p24 levels in HIV-1-infected primary CD4+ T cells, Jurkat cells, and MOLT-X4 cells, suggesting mTOR kinase regulates HIV-1 production PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ44809

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase III type 1 promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase III type 2 promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase III type 3 promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables TFIIIC-class transcription factor complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA damage response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in T cell costimulation TAS
    Traceable Author Statement
    more info
     
    involved_in T-helper 1 cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in TOR signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in anoikis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in behavioral response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcineurin-NFAT signaling cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amino acid starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to amino acid stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to hypoxia NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to leucine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to leucine starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to nutrient IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to nutrient levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to nutrient levels ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to nutrient levels NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to osmotic stress NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in energy reserve metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in germ cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heart morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heart valve morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lysosome organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in macroautophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of autophagy NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of calcineurin-NFAT signaling cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of lysosome organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of macroautophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuronal action potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleus localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cytoplasmic translational initiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of glycolytic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of keratinocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lipid biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of myotube differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of pentose-phosphate shunt NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of phosphoprotein phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of wound healing, spreading of epidermal cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of protein destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of autophagosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cellular response to heat TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of locomotor rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of macroautophagy TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of membrane permeability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of osteoclast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
     
    involved_in response to amino acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to nutrient levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ruffle organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in voluntary musculoskeletal movement IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of TORC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of TORC1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of TORC1 complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of TORC1 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of TORC2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of TORC2 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane HDA PubMed 
    is_active_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase mTOR
    Names
    FK506 binding protein 12-rapamycin associated protein 2
    FK506-binding protein 12-rapamycin complex-associated protein 1
    FKBP-rapamycin associated protein
    FKBP12-rapamycin complex-associated protein 1
    mammalian target of rapamycin
    mechanistic target of rapamycin (serine/threonine kinase)
    rapamycin and FKBP12 target 1
    rapamycin associated protein FRAP2
    rapamycin target protein 1
    NP_001373429.1
    NP_001373430.1
    NP_004949.1
    XP_011539468.1
    XP_016856389.1
    XP_047272677.1
    XP_047272680.1
    XP_054191719.1
    XP_054191720.1
    XP_054191721.1
    XP_054191722.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033239.1 RefSeqGene

      Range
      5001..161021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_734

    mRNA and Protein(s)

    1. NM_001386500.1NP_001373429.1  serine/threonine-protein kinase mTOR isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AL049653, AL109811, AL391561
      Consensus CDS
      CCDS127.1
      UniProtKB/Swiss-Prot
      P42345, Q4LE76, Q5TER1, Q6LE87, Q96QG3, Q9Y4I3
      UniProtKB/TrEMBL
      A0A8V8TRG9
      Conserved Domains (2) summary
      COG5032
      Location:3632549
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      sd00044
      Location:655681
      HEAT; HEAT repeat [structural motif]
    2. NM_001386501.1NP_001373430.1  serine/threonine-protein kinase mTOR isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL049653, AL109811, AL391561
      UniProtKB/TrEMBL
      A0A8V8TRG9
      Conserved Domains (2) summary
      COG5032
      Location:662133
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      sd00044
      Location:239265
      HEAT; HEAT repeat [structural motif]
    3. NM_004958.4NP_004949.1  serine/threonine-protein kinase mTOR isoform 1

      See identical proteins and their annotated locations for NP_004949.1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AA725390, AB209995, BC117166, BP250183, DC403129, L34075, U88966
      Consensus CDS
      CCDS127.1
      UniProtKB/Swiss-Prot
      P42345, Q4LE76, Q5TER1, Q6LE87, Q96QG3, Q9Y4I3
      UniProtKB/TrEMBL
      A0A8V8TRG9
      Related
      ENSP00000354558.4, ENST00000361445.9
      Conserved Domains (2) summary
      COG5032
      Location:3632549
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      sd00044
      Location:655681
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      11106535..11262551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000900.1XP_016856389.1  serine/threonine-protein kinase mTOR isoform X2

      UniProtKB/TrEMBL
      A0A8V8TRG9
    2. XM_047416724.1XP_047272680.1  serine/threonine-protein kinase mTOR isoform X3

    3. XM_047416721.1XP_047272677.1  serine/threonine-protein kinase mTOR isoform X1

      UniProtKB/TrEMBL
      A0A8V8TRG9
    4. XM_011541166.3XP_011539468.1  serine/threonine-protein kinase mTOR isoform X4

      UniProtKB/TrEMBL
      A0A8V8TQ52, A0A8V8TQM6
      Related
      ENSP00000515198.1, ENST00000703141.1
      Conserved Domains (3) summary
      COG5032
      Location:3631587
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      pfam11865
      Location:8541024
      DUF3385; Domain of unknown function (DUF3385)
      sd00044
      Location:655681
      HEAT; HEAT repeat [structural motif]

    RNA

    1. XR_007058581.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      10648106..10804142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335745.1XP_054191720.1  serine/threonine-protein kinase mTOR isoform X2

      UniProtKB/TrEMBL
      A0A8V8TRG9
    2. XM_054335746.1XP_054191721.1  serine/threonine-protein kinase mTOR isoform X3

    3. XM_054335744.1XP_054191719.1  serine/threonine-protein kinase mTOR isoform X1

      UniProtKB/TrEMBL
      A0A8V8TRG9
    4. XM_054335747.1XP_054191722.1  serine/threonine-protein kinase mTOR isoform X4

      UniProtKB/TrEMBL
      A0A8V8TQ52, A0A8V8TQM6

    RNA

    1. XR_008485983.1 RNA Sequence