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    IRF3 interferon regulatory factor 3 [ Homo sapiens (human) ]

    Gene ID: 3661, updated on 5-Feb-2024

    Summary

    Official Symbol
    IRF3provided by HGNC
    Official Full Name
    interferon regulatory factor 3provided by HGNC
    Primary source
    HGNC:HGNC:6118
    See related
    Ensembl:ENSG00000126456 MIM:603734; AllianceGenome:HGNC:6118
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IIAE7
    Summary
    This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in spleen (RPKM 23.8), lymph node (RPKM 21.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IRF3 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49659572..49665857, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52659601..52665933, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50162829..50169114, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50139452-50140018 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50143247-50143916 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50143917-50144586 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50144587-50145256 Neighboring gene RAS related Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10927 Neighboring gene SR-related CTD associated factor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50158945-50159720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50161341-50162044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10929 Neighboring gene BCL2 like 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50175361-50175919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14954 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:50180167-50180898 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:50184019-50184183 Neighboring gene protein arginine methyltransferase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10932 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10933 Neighboring gene microRNA 5088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50190450-50191191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50191192-50191932 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10934 Neighboring gene adrenomedullin 5 (putative)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 CN54 Env (gp120) induces phosphorylation of RELA (p65), IRF3, MAPK14 (p38), and MAPK1 (ERK1/2) through TLR4 induction in monocyte derived macrophages; anti-TLR4 antibodies could inhibit this activation PubMed
    Nef nef HIV-1 Nef myristoylation is required for the activation of IRF-3, leading to the synthesis of IFNbeta in monocytes-derived-macrophages PubMed
    nef The acidic cluster (residues 64-69) of HIV-1 Nef is required for IRF-3 activation and IFNbeta production PubMed
    Tat tat HIV-1 Tat-mediated downregulation of TRAF3 increases levels of phosphorylation of IRF3 and IRF7 in human microglial cells PubMed
    Vif vif HIV-1 Vpr and Vif proteins cooperate with HIV-1 Vpu to induce IRF3 cleavage, although their individual effects are weaker than those of Vpu PubMed
    vif Virion-associated accessory proteins Vif and Vpr can independently degrade IRF-3. Eleven lysine residues in the N-terminal domain of IRF-3 are important for the Vif and Vpr mediated degradation PubMed
    Vpr vpr HIV-1 Vpr and Vif proteins cooperate with HIV-1 Vpu to induce IRF3 cleavage, although their individual effects are weaker than those of Vpu PubMed
    vpr HIV-1 Vpr-mediated suppression of IFN induction is caused by failure of IRF-3 nucleus translocation PubMed
    vpr Virion-associated accessory proteins Vif and Vpr can independently degrade IRF-3. Eleven lysine residues in the N-terminal domain of IRF-3 are important for the Vif and Vpr mediated degradation PubMed
    Vpu vpu HIV-1 Vpr and Vif proteins cooperate with HIV-1 Vpu to induce IRF3 cleavage, although their individual effects are weaker than those of Vpu PubMed
    vpu Residue Asp121 is the primary site for Vpu-induced, caspase-mediated IRF3 cleavage, and the alternative site is residues Asp125 when Asp121 is mutated PubMed
    vpu Caspase-8 and caspase-3 activity are required for HIV-1 Vpu-induced cleavage of IRF3 and HIV-1 infection also induces caspase-mediated IRF3 cleavage PubMed
    vpu HIV-1 Vpu-induced cleavage of IRF3 is largely dependent on the ability of Vpu to interact with beta-TrCP, and mutation of the Vpu phosphorylation sites Ser52 and Ser56 greatly decreases the function of Vpu-induced IRF3 cleavage PubMed
    vpu HIV-1 Vpu co-localizes with IRF3 during HIV protein expression PubMed
    vpu Interaction of HIV-1 Vpu with IRF3 governs the innate immune response of the host cell to HIV-1 infection PubMed
    vpu HIV-1 Vpu forms a stable and specific complex with IRF3 in HIV-1-infected cells, resulting in its specific sequestration within the endo-lysosomal compartment PubMed
    capsid gag HIV-1 CA mutants N74D and P90A fail to bind to CPSF6 and cyclophilins (Nup358 and CypA), respectively, and trigger innate sensors, leading to nuclear translocation of NFkappaB and IRF3, production of type 1 IFN and induction of an antiviral state PubMed
    reverse transcriptase gag-pol The reverse-transcribed viral DNA by HIV-1 RT is the trigger of IRF3 activation and IFN-beta production in HIV-1 infected human monocytic cell line THP1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA-binding transcription factor activity IC
    Inferred by Curator
    more info
    PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables promoter-specific chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in MDA-5 signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in TRIF-dependent toll-like receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to exogenous dsRNA IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytoplasmic pattern recognition receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macrophage apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interferon-alpha production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interferon-beta production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of type I interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of type I interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in programmed necrotic cell death IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in type I interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    interferon regulatory factor 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031810.1 RefSeqGene

      Range
      5019..11304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001197122.2NP_001184051.1  interferon regulatory factor 3 isoform 2

      See identical proteins and their annotated locations for NP_001184051.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a longer protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      BC000660, DA999381
      Consensus CDS
      CCDS59409.1
      UniProtKB/TrEMBL
      M0QZB7
      Related
      ENSP00000471896.1, ENST00000601291.5
      Conserved Domains (2) summary
      pfam00605
      Location:7110
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:202326
      IRF-3; Interferon-regulatory factor 3
    2. NM_001197123.2NP_001184052.1  interferon regulatory factor 3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as IRF3a) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC000660, BP347627, BU859806, DA999381, HM357932, HM357934
      UniProtKB/TrEMBL
      E2GIM5
      Conserved Domains (2) summary
      pfam10401
      Location:167345
      IRF-3; Interferon-regulatory factor 3
      cl00096
      Location:2175
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
    3. NM_001197124.2NP_001184053.1  interferon regulatory factor 3 isoform 4

      See identical proteins and their annotated locations for NP_001184053.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as IRF3e and IRF3-nirs3) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      BC000660, BU859806, DA999381, HM357935, HM357936
      Consensus CDS
      CCDS56099.1
      UniProtKB/TrEMBL
      E2GIM9
      Related
      ENSP00000471358.1, ENST00000599223.5
      Conserved Domains (2) summary
      pfam00605
      Location:7110
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:200253
      IRF-3; Interferon-regulatory factor 3
    4. NM_001197125.2NP_001184054.1  interferon regulatory factor 3 isoform 5

      See identical proteins and their annotated locations for NP_001184054.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as IRF3f) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1. Both variants 5 and 6 encode the same isoform (5).
      Source sequence(s)
      BC000660, BU859806, DA999381, HM357937
      Consensus CDS
      CCDS59408.1
      UniProtKB/TrEMBL
      M0QYT9
      Related
      ENSP00000366339.5, ENST00000377135.8
      Conserved Domains (1) summary
      pfam10401
      Location:56234
      IRF-3; Interferon-regulatory factor 3
    5. NM_001197126.2NP_001184055.1  interferon regulatory factor 3 isoform 5

      See identical proteins and their annotated locations for NP_001184055.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6, also known as IRF3c) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1. Both variants 5 and 6 encode the same isoform (5).
      Source sequence(s)
      BC000660, BU859806, DA999381, HM357934
      Consensus CDS
      CCDS59408.1
      UniProtKB/TrEMBL
      M0QYT9
      Related
      ENSP00000470069.1, ENST00000599144.5
      Conserved Domains (1) summary
      pfam10401
      Location:56234
      IRF-3; Interferon-regulatory factor 3
    6. NM_001197127.2NP_001184056.1  interferon regulatory factor 3 isoform 6

      See identical proteins and their annotated locations for NP_001184056.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7, also known as IRF3d) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant also lacks an in-frame exon compared to variant 1. The encoded isoform (6) is shorter than isoform 1. Both variants 7 and 8 encode the same isoform (6).
      Source sequence(s)
      BC000660, BU859806, DA999381, HM357935
      Consensus CDS
      CCDS59407.1
      UniProtKB/TrEMBL
      E2GIM8
      Related
      ENSP00000472700.1, ENST00000600022.5
      Conserved Domains (1) summary
      pfam10401
      Location:54107
      IRF-3; Interferon-regulatory factor 3
    7. NM_001197128.2NP_001184057.1  interferon regulatory factor 3 isoform 6

      See identical proteins and their annotated locations for NP_001184057.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8, also known as IRF3b) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant also lacks an in-frame exon compared to variant 1. The encoded isoform (6) is shorter than isoform 1. Both variants 7 and 8 encode the same isoform (6).
      Source sequence(s)
      BC000660, BU859806, DA999381, HM357933, HM357935
      Consensus CDS
      CCDS59407.1
      UniProtKB/TrEMBL
      E2GIM8
      Related
      ENSP00000470512.1, ENST00000596765.5
      Conserved Domains (1) summary
      pfam10401
      Location:54107
      IRF-3; Interferon-regulatory factor 3
    8. NM_001571.6NP_001562.1  interferon regulatory factor 3 isoform 1

      See identical proteins and their annotated locations for NP_001562.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC011495, DA999381, Z56281
      Consensus CDS
      CCDS12775.1
      UniProtKB/Swiss-Prot
      A8K7L2, B2RAZ3, Q14653, Q5FBY1, Q5FBY2, Q5FBY4, Q7Z5G6
      UniProtKB/TrEMBL
      E2GIM5
      Related
      ENSP00000366344.3, ENST00000377139.8
      Conserved Domains (2) summary
      pfam00605
      Location:7110
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:202380
      IRF-3; Interferon-regulatory factor 3

    RNA

    1. NR_045568.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses an alternate splice site in the 5' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA568913, AK292027, DA938709

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      49659572..49665857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438784.1XP_047294740.1  interferon regulatory factor 3 isoform X6

    2. XM_017026767.2XP_016882256.1  interferon regulatory factor 3 isoform X2

      UniProtKB/Swiss-Prot
      A8K7L2, B2RAZ3, Q14653, Q5FBY1, Q5FBY2, Q5FBY4, Q7Z5G6
      UniProtKB/TrEMBL
      E2GIM5
      Related
      ENSP00000310127.6, ENST00000309877.11
      Conserved Domains (2) summary
      pfam00605
      Location:7110
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:202380
      IRF-3; Interferon-regulatory factor 3
    3. XM_006723198.2XP_006723261.1  interferon regulatory factor 3 isoform X1

      See identical proteins and their annotated locations for XP_006723261.1

      UniProtKB/TrEMBL
      M0QZB7
      Related
      ENSP00000470431.1, ENST00000600911.5
      Conserved Domains (2) summary
      pfam00605
      Location:7110
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:202326
      IRF-3; Interferon-regulatory factor 3
    4. XM_024451495.2XP_024307263.1  interferon regulatory factor 3 isoform X6

      Conserved Domains (1) summary
      pfam10401
      Location:56180
      IRF-3; Interferon-regulatory factor 3
    5. XM_017026766.2XP_016882255.1  interferon regulatory factor 3 isoform X2

      UniProtKB/Swiss-Prot
      A8K7L2, B2RAZ3, Q14653, Q5FBY1, Q5FBY2, Q5FBY4, Q7Z5G6
      UniProtKB/TrEMBL
      E2GIM5
      Conserved Domains (2) summary
      pfam00605
      Location:7110
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:202380
      IRF-3; Interferon-regulatory factor 3
    6. XM_006723197.1XP_006723260.1  interferon regulatory factor 3 isoform X1

      See identical proteins and their annotated locations for XP_006723260.1

      UniProtKB/TrEMBL
      M0QZB7
      Conserved Domains (2) summary
      pfam00605
      Location:7110
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:202326
      IRF-3; Interferon-regulatory factor 3
    7. XM_006723201.2XP_006723264.1  interferon regulatory factor 3 isoform X6

      See identical proteins and their annotated locations for XP_006723264.1

      Conserved Domains (1) summary
      pfam10401
      Location:56180
      IRF-3; Interferon-regulatory factor 3
    8. XM_047438785.1XP_047294741.1  interferon regulatory factor 3 isoform X7

      UniProtKB/TrEMBL
      M0QYT9
      Related
      ENSP00000472582.1, ENST00000598808.5
    9. XM_024451494.2XP_024307262.1  interferon regulatory factor 3 isoform X6

      Conserved Domains (1) summary
      pfam10401
      Location:56180
      IRF-3; Interferon-regulatory factor 3
    10. XM_006723200.2XP_006723263.1  interferon regulatory factor 3 isoform X3

      UniProtKB/TrEMBL
      M0QZB7
      Conserved Domains (2) summary
      pfam10401
      Location:167291
      IRF-3; Interferon-regulatory factor 3
      cl00096
      Location:2175
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
    11. XM_047438783.1XP_047294739.1  interferon regulatory factor 3 isoform X5

      UniProtKB/TrEMBL
      E2GIM5
    12. XM_047438782.1XP_047294738.1  interferon regulatory factor 3 isoform X4

      UniProtKB/TrEMBL
      M0QZB7

    RNA

    1. XR_007066794.1 RNA Sequence

    2. XR_007066795.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      52659601..52665933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320902.1XP_054176877.1  interferon regulatory factor 3 isoform X2

      UniProtKB/TrEMBL
      E2GIM5
    2. XM_054320900.1XP_054176875.1  interferon regulatory factor 3 isoform X1

      UniProtKB/TrEMBL
      M0QZB7, Q96GL3
    3. XM_054320908.1XP_054176883.1  interferon regulatory factor 3 isoform X6

    4. XM_054320909.1XP_054176884.1  interferon regulatory factor 3 isoform X7

      UniProtKB/TrEMBL
      E2GIM7
    5. XM_054320907.1XP_054176882.1  interferon regulatory factor 3 isoform X6

    6. XM_054320901.1XP_054176876.1  interferon regulatory factor 3 isoform X1

      UniProtKB/TrEMBL
      M0QZB7, Q96GL3
    7. XM_054320903.1XP_054176878.1  interferon regulatory factor 3 isoform X3

      UniProtKB/TrEMBL
      M0QZB7
    8. XM_054320905.1XP_054176880.1  interferon regulatory factor 3 isoform X5

      UniProtKB/TrEMBL
      E2GIM5
    9. XM_054320904.1XP_054176879.1  interferon regulatory factor 3 isoform X4

      UniProtKB/TrEMBL
      M0QZB7
    10. XM_054320906.1XP_054176881.1  interferon regulatory factor 3 isoform X8

      UniProtKB/TrEMBL
      M0QZB8

    RNA

    1. XR_008485138.1 RNA Sequence

    2. XR_008485139.1 RNA Sequence