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    NAXE NAD(P)HX epimerase [ Homo sapiens (human) ]

    Gene ID: 128240, updated on 1-Mar-2024

    Summary

    Official Symbol
    NAXEprovided by HGNC
    Official Full Name
    NAD(P)HX epimeraseprovided by HGNC
    Primary source
    HGNC:HGNC:18453
    See related
    Ensembl:ENSG00000163382 MIM:608862; AllianceGenome:HGNC:18453
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIBP; PEBEL; YJEFN1; APOA1BP
    Summary
    The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 11.3), prostate (RPKM 10.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NAXE in Genome Data Viewer
    Location:
    1q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156591776..156594299)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155728152..155730675)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156561568..156564091)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene IQ motif containing GTPase activating protein 3 Neighboring gene NANOG hESC enhancer GRCh37_chr1:156508711-156509291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1873 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156554411-156554912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156554913-156555412 Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156561722-156562568 Neighboring gene G-patch domain containing 4 (gene/pseudogene) Neighboring gene hyaluronan and proteoglycan link protein 2 Neighboring gene uncharacterized LOC101928177

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC119143, MGC119144, MGC119145

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NADHX epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NADPHX epimerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane raft distribution IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nicotinamide nucleotide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    NAD(P)H-hydrate epimerase
    Names
    AI-BP
    apoA-I binding protein
    apolipoprotein A-I-binding protein
    yjeF N-terminal domain-containing protein 1
    yjeF_N1
    NP_658985.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052542.1 RefSeqGene

      Range
      5011..7534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144772.3NP_658985.2  NAD(P)H-hydrate epimerase precursor

      See identical proteins and their annotated locations for NP_658985.2

      Status: REVIEWED

      Source sequence(s)
      AL365181, BC100933, BG723681, BQ430064
      Consensus CDS
      CCDS1145.1
      UniProtKB/Swiss-Prot
      B4DGY3, Q496C6, Q5T3I2, Q8NCW5
      UniProtKB/TrEMBL
      B4DP80
      Related
      ENSP00000357218.3, ENST00000368235.8
      Conserved Domains (1) summary
      cl00318
      Location:52287
      YjeF_N; YjeF-related protein N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      156591776..156594299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791758.1 Reference GRCh38.p14 PATCHES

      Range
      150333..152856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      155728152..155730675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)