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    ODAD4 outer dynein arm docking complex subunit 4 [ Homo sapiens (human) ]

    Gene ID: 83538, updated on 23-Nov-2023

    Summary

    Official Symbol
    ODAD4provided by HGNC
    Official Full Name
    outer dynein arm docking complex subunit 4provided by HGNC
    Primary source
    HGNC:HGNC:25280
    See related
    Ensembl:ENSG00000204815 MIM:617095; AllianceGenome:HGNC:25280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TTC25
    Summary
    This gene encodes a tetratricopeptide repeat domain-containing protein that localizes to ciliary axonmenes and plays a role in the docking of the outer dynein arm to cilia. Mutations in this gene cause severely reduced ciliary motility and the disorder CILD35 (ciliary dyskinesia,primary, 35). Primary ciliary dyskinesia is often associated with recurrent respiratory infections, immotile spermatozoa, and situs inversus; an inversion in left-right body symmetry. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]
    Expression
    Biased expression in testis (RPKM 20.2) and lung (RPKM 1.7) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ODAD4 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41930617..41966503)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42787128..42823000)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40086870..40118521)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40019607-40020116 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8503 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40021860-40022360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40022361-40022861 Neighboring gene kelch like family member 11 Neighboring gene uncharacterized LOC124904005 Neighboring gene MPRA-validated peak2844 silencer Neighboring gene ATP citrate lyase Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:40066298-40067497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8504 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8505 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40085993-40086896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12176 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40091696-40092276 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:40102816-40102967 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40110957-40111564 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40111565-40112170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40112171-40112776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40112777-40113382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40119287-40119844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40119845-40120402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40120403-40120960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12179 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:40139962-40140462 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:40140463-40140963 Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:40162959-40163488 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:40168666-40169865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12182 Neighboring gene NFKB inhibitor interacting Ras like 2 Neighboring gene zinc finger protein 385C

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp434H0115

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebrospinal fluid circulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium movement IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cilium movement ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epithelial cilium movement involved in determination of left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mucociliary clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in outer dynein arm assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in outer dynein arm assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to motile cilium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in 9+0 motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in 9+2 motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    part_of outer dynein arm docking complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    outer dynein arm-docking complex subunit 4
    Names
    TPR repeat protein 25
    tetratricopeptide repeat domain 25
    tetratricopeptide repeat protein 25

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053115.1 RefSeqGene

      Range
      5024..40910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001350319.2NP_001337248.1  outer dynein arm-docking complex subunit 4 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an internal exon which results in a shift in the reading frame, compared to variant 1. This variant encodes isoform (2) which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC125257, AL136760, CB242540
      Conserved Domains (3) summary
      sd00006
      Location:1641
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:318391
      TPR_12; Tetratricopeptide repeat
      cl26005
      Location:20101
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    2. NM_031421.5NP_113609.1  outer dynein arm-docking complex subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_113609.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC125257, AL136760, CB242540
      Consensus CDS
      CCDS74063.1
      UniProtKB/Swiss-Prot
      Q6NX40, Q6PJ04, Q96NG3, Q9H0K5
      Related
      ENSP00000478589.1, ENST00000377540.6
      Conserved Domains (3) summary
      sd00006
      Location:1641
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:1678
      TPR_11; TPR repeat
      pfam13424
      Location:361429
      TPR_12; Tetratricopeptide repeat

    RNA

    1. NR_110662.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC125257, AL136760, BC025390, CB242540
    2. NR_146621.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC125257, BC025390, CB242540, CF593846
    3. NR_146622.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences in the 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC125257, AL136760, CB242540, CF593846

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      41930617..41966503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      42787128..42823000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)