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    CDC45 cell division cycle 45 [ Homo sapiens (human) ]

    Gene ID: 8318, updated on 3-Apr-2024

    Summary

    Official Symbol
    CDC45provided by HGNC
    Official Full Name
    cell division cycle 45provided by HGNC
    Primary source
    HGNC:HGNC:1739
    See related
    Ensembl:ENSG00000093009 MIM:603465; AllianceGenome:HGNC:1739
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDC45L; MGORS7; CDC45L2; PORC-PI-1
    Summary
    The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Expression
    Biased expression in testis (RPKM 11.5), bone marrow (RPKM 6.8) and 11 other tissues See more
    Orthologs
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    Genomic context

    Location:
    22q11.21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (19479466..19520612)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (19856299..19897453)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (19466989..19508135)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:19434430-19435332 Neighboring gene chromosome 22 open reading frame 39 Neighboring gene UFD1 antisense RNA 1 Neighboring gene ubiquitin recognition factor in ER associated degradation 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13463 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:19486137-19486353 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19493394-19493894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19493895-19494395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19502006-19502506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19502507-19503007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19509616-19510548 Neighboring gene claudin 5 Neighboring gene MPRA-validated peak4453 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19531837-19532336 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19542168-19542870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19542871-19543573 Neighboring gene long intergenic non-protein coding RNA 895

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in DNA replication checkpoint signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA unwinding involved in DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic DNA replication preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of CMG complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of DNA replication preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
     
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cell division control protein 45 homolog
    Names
    CDC45 cell division cycle 45 homolog
    CDC45 cell division cycle 45-like
    CDC45-related protein
    cell division cycle 45 homolog
    cell division cycle 45-like 2
    human CDC45

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052958.1 RefSeqGene

      Range
      5095..45783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178010.2NP_001171481.1  cell division control protein 45 homolog isoform 1

      See identical proteins and their annotated locations for NP_001171481.1

      Status: REVIEWED

      Source sequence(s)
      AC000088, AF081535, AK293338, HY016491
      Consensus CDS
      CCDS54499.1
      UniProtKB/Swiss-Prot
      O75419
      Related
      ENSP00000405726.2, ENST00000437685.6
      Conserved Domains (1) summary
      pfam02724
      Location:19593
      CDC45; CDC45-like protein
    2. NM_001178011.2NP_001171482.1  cell division control protein 45 homolog isoform 3

      See identical proteins and their annotated locations for NP_001171482.1

      Status: REVIEWED

      Source sequence(s)
      AC000087, AF081535, AK293123, HY016491
      Consensus CDS
      CCDS54500.1
      UniProtKB/Swiss-Prot
      O75419
      Related
      ENSP00000384978.3, ENST00000404724.7
      Conserved Domains (1) summary
      pfam02724
      Location:19515
      CDC45; CDC45-like protein
    3. NM_001369291.1NP_001356220.1  cell division control protein 45 homolog isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC000082, AC000087, AC000088
      Conserved Domains (1) summary
      pfam02724
      Location:7549
      CDC45; CDC45-like protein
    4. NM_003504.5NP_003495.1  cell division control protein 45 homolog isoform 2

      See identical proteins and their annotated locations for NP_003495.1

      Status: REVIEWED

      Source sequence(s)
      AC000082, AC000087, AC000088
      Consensus CDS
      CCDS13762.1
      UniProtKB/Swiss-Prot
      B4DDB4, B4DDU3, E9PDH7, O60856, O75419, Q20WK8, Q6UW54, Q9UP68
      Related
      ENSP00000263201.2, ENST00000263201.7
      Conserved Domains (1) summary
      pfam02724
      Location:19561
      CDC45; CDC45-like protein

    RNA

    1. NR_161281.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC000082, AC000087, AC000088
      Related
      ENST00000438587.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      19479466..19520612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441534.1XP_047297490.1  cell division control protein 45 homolog isoform X8

    2. XM_047441531.1XP_047297487.1  cell division control protein 45 homolog isoform X1

    3. XM_047441532.1XP_047297488.1  cell division control protein 45 homolog isoform X2

      UniProtKB/Swiss-Prot
      B4DDB4, B4DDU3, E9PDH7, O60856, O75419, Q20WK8, Q6UW54, Q9UP68
    4. XM_011530417.4XP_011528719.1  cell division control protein 45 homolog isoform X4

      Conserved Domains (1) summary
      pfam02724
      Location:19516
      CDC45; CDC45-like protein
    5. XM_011530418.4XP_011528720.1  cell division control protein 45 homolog isoform X5

      See identical proteins and their annotated locations for XP_011528720.1

      UniProtKB/Swiss-Prot
      O75419
      Conserved Domains (1) summary
      pfam02724
      Location:19515
      CDC45; CDC45-like protein
    6. XM_011530416.2XP_011528718.1  cell division control protein 45 homolog isoform X3

      Conserved Domains (1) summary
      pfam02724
      Location:7550
      CDC45; CDC45-like protein
    7. XM_047441533.1XP_047297489.1  cell division control protein 45 homolog isoform X6

      Related
      ENSP00000499976.1, ENST00000672837.1
    8. XM_017028966.2XP_016884455.1  cell division control protein 45 homolog isoform X7

      UniProtKB/TrEMBL
      A0A5K1VW85
      Related
      ENSP00000385240.2, ENST00000407835.6
      Conserved Domains (1) summary
      pfam02724
      Location:4392
      CDC45; CDC45-like protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      19856299..19897453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325997.1XP_054181972.1  cell division control protein 45 homolog isoform X8

    2. XM_054325990.1XP_054181965.1  cell division control protein 45 homolog isoform X1

    3. XM_054325991.1XP_054181966.1  cell division control protein 45 homolog isoform X2

      UniProtKB/Swiss-Prot
      B4DDB4, B4DDU3, E9PDH7, O60856, O75419, Q20WK8, Q6UW54, Q9UP68
    4. XM_054325993.1XP_054181968.1  cell division control protein 45 homolog isoform X4

    5. XM_054325994.1XP_054181969.1  cell division control protein 45 homolog isoform X5

    6. XM_054325992.1XP_054181967.1  cell division control protein 45 homolog isoform X3

    7. XM_054325995.1XP_054181970.1  cell division control protein 45 homolog isoform X6

    8. XM_054325996.1XP_054181971.1  cell division control protein 45 homolog isoform X7