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    GNB1 G protein subunit beta 1 [ Homo sapiens (human) ]

    Gene ID: 2782, updated on 5-May-2024

    Summary

    Official Symbol
    GNB1provided by HGNC
    Official Full Name
    G protein subunit beta 1provided by HGNC
    Primary source
    HGNC:HGNC:4396
    See related
    Ensembl:ENSG00000078369 MIM:139380; AllianceGenome:HGNC:4396
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MDS; HG2A; MRD42
    Summary
    Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
    Expression
    Ubiquitous expression in brain (RPKM 145.4), small intestine (RPKM 87.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GNB1 in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1785286..1891087, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (1219664..1325475, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1716725..1822526, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S7 pseudogene Neighboring gene solute carrier family 35 member E2A (pseudogene) Neighboring gene uncharacterized LOC112268218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 89 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1684563-1685092 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1691433-1692390 Neighboring gene NAD kinase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1705547-1706048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 90 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 33 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 35 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 36 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 34 Neighboring gene Sharpr-MPRA regulatory region 14484 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1721473-1721656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 38 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 91 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 39 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1757447-1758350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 41 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1782535-1783035 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1783210-1784022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 42 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 43 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 44 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1798007-1798184 Neighboring gene Sharpr-MPRA regulatory region 3728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1820039-1820538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 92 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 93 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 94 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 95 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 96 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 97 Neighboring gene GNB1 divergent transcript Neighboring gene uncharacterized LOC124903822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 45 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 98

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Acute lymphoid leukemia
    MedGen: C0023449 OMIM: 613065 GeneReviews: Not available
    Compare labs
    Intellectual disability, autosomal dominant 42
    MedGen: C4310774 OMIM: 616973 GeneReviews: GNB1 Encephalopathy
    Compare labs
    Myelodysplastic syndrome
    MedGen: C3463824 OMIM: 614286 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2019-01-23)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2019-01-23)

    ClinGen Genome Curation PagePubMed

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Expression of HIV-1 Tat upregulates the abundance of guanine nucleotide binding protein (G protein), beta polypeptide 1 (GNB1) in the nucleoli of Jurkat T-cells PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of guanine nucleotide binding protein, beta polypeptide 1 (GNB1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor complex adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular vesicle HDA PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of heterotrimeric G-protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane HDA PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in photoreceptor disc membrane TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Names
    beta subunit, signal-transducing proteins GS/GI
    guanine nucleotide binding protein (G protein), beta polypeptide 1
    heterotrimeric guanine nucleotide-binding protein 2A
    testicular tissue protein Li 72
    transducin beta chain 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047052.1 RefSeqGene

      Range
      5031..110832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001282538.2NP_001269467.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform 2

      See identical proteins and their annotated locations for NP_001269467.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI092255, AK122949, BC004186, BQ881467
      Consensus CDS
      CCDS72685.1
      UniProtKB/TrEMBL
      B3KVK2, Q71UM6
      Related
      ENSP00000483532.1, ENST00000615252.5
      Conserved Domains (2) summary
      cd00200
      Location:2240
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:141
      7WD40; WD40 repeat [structural motif]
    2. NM_001282539.2NP_001269468.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform 1

      See identical proteins and their annotated locations for NP_001269468.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AI092255, BC004186, BU902364
      Consensus CDS
      CCDS34.1
      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8, A0A2L0WW42
      Related
      ENSP00000481878.1, ENST00000610897.4
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]
    3. NM_002074.5NP_002065.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform 1

      See identical proteins and their annotated locations for NP_002065.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AI092255, BC004186, BQ881467
      Consensus CDS
      CCDS34.1
      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8, A0A2L0WW42
      Related
      ENSP00000367872.3, ENST00000378609.9
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1785286..1891087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418078.1XP_047274034.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      F6X3N5
    2. XM_047418076.1XP_047274032.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      F6X3N5
      Related
      ENSP00000515441.1, ENST00000703707.1
    3. XM_017001061.3XP_016856550.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8, A0A2L0WW42
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]
    4. XM_047418072.1XP_047274028.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      F6X3N5
      Related
      ENSP00000399741.3, ENST00000439272.7
    5. XM_017001060.3XP_016856549.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8, A0A2L0WW42
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]
    6. XM_047418073.1XP_047274029.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      F6X3N5
    7. XM_047418070.1XP_047274026.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    8. XM_047418049.1XP_047274005.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
      Related
      ENSP00000515440.1, ENST00000703706.1
    9. XM_047418071.1XP_047274027.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    10. XM_047418061.1XP_047274017.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    11. XM_047418054.1XP_047274010.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    12. XM_047418042.1XP_047273998.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
      Related
      ENSP00000515443.1, ENST00000703709.1
    13. XM_047418059.1XP_047274015.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    14. XM_047418050.1XP_047274006.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    15. XM_047418057.1XP_047274013.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    16. XM_047418044.1XP_047274000.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    17. XM_047418046.1XP_047274002.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    18. XM_047418045.1XP_047274001.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    19. XM_024446495.2XP_024302263.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8, A0A2L0WW42
      Related
      ENSP00000515434.1, ENST00000703700.1
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]
    20. XM_047418058.1XP_047274014.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
      Related
      ENSP00000515428.1, ENST00000703693.1
    21. XM_047418068.1XP_047274024.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
      Related
      ENSP00000515432.1, ENST00000703697.1
    22. XM_047418056.1XP_047274012.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
      Related
      ENSP00000515442.1, ENST00000703708.1
    23. XM_047418074.1XP_047274030.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      F6X3N5
    24. XM_047418055.1XP_047274011.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    25. XM_047418062.1XP_047274018.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    26. XM_047418043.1XP_047273999.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
      Related
      ENSP00000515435.1, ENST00000703701.1
    27. XM_047418069.1XP_047274025.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    28. XM_047418063.1XP_047274019.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    29. XM_047418060.1XP_047274016.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
      Related
      ENSP00000515438.1, ENST00000703704.1
    30. XM_047418067.1XP_047274023.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    31. XM_017001059.3XP_016856548.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8, A0A2L0WW42
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      1219664..1325475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336086.1XP_054192061.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      F6X3N5
    2. XM_054336085.1XP_054192060.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      F6X3N5
    3. XM_054336079.1XP_054192054.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    4. XM_054336082.1XP_054192057.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      F6X3N5
    5. XM_054336073.1XP_054192048.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    6. XM_054336083.1XP_054192058.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      F6X3N5
    7. XM_054336077.1XP_054192052.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    8. XM_054336061.1XP_054192036.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    9. XM_054336078.1XP_054192053.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    10. XM_054336070.1XP_054192045.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    11. XM_054336063.1XP_054192038.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    12. XM_054336055.1XP_054192030.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    13. XM_054336068.1XP_054192043.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    14. XM_054336062.1XP_054192037.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    15. XM_054336066.1XP_054192041.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    16. XM_054336058.1XP_054192033.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    17. XM_054336060.1XP_054192035.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    18. XM_054336059.1XP_054192034.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    19. XM_054336056.1XP_054192031.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    20. XM_054336067.1XP_054192042.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    21. XM_054336075.1XP_054192050.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    22. XM_054336065.1XP_054192040.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    23. XM_054336084.1XP_054192059.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      F6X3N5
    24. XM_054336064.1XP_054192039.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    25. XM_054336071.1XP_054192046.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    26. XM_054336057.1XP_054192032.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    27. XM_054336076.1XP_054192051.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    28. XM_054336072.1XP_054192047.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    29. XM_054336069.1XP_054192044.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    30. XM_054336074.1XP_054192049.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    31. XM_054336080.1XP_054192055.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8
    32. XM_054336081.1XP_054192056.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      B1AJZ7, P04697, P04901, P62873, Q1RMY8
      UniProtKB/TrEMBL
      A0A024R056, A0A140VJJ8