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    BGN biglycan [ Homo sapiens (human) ]

    Gene ID: 633, updated on 23-Nov-2023

    Summary

    Official Symbol
    BGNprovided by HGNC
    Official Full Name
    biglycanprovided by HGNC
    Primary source
    HGNC:HGNC:1044
    See related
    Ensembl:ENSG00000182492 MIM:301870; AllianceGenome:HGNC:1044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGI; MRLS; DSPG1; PG-S1; SEMDX; SLRR1A
    Summary
    This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]
    Expression
    Broad expression in gall bladder (RPKM 206.5), spleen (RPKM 159.3) and 20 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See BGN in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (153494980..153509546)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (151768553..151783109)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (152760438..152775004)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene three prime repair exonuclease 2 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:152726424-152726582 Neighboring gene HAUS augmin like complex subunit 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30034 Neighboring gene Sharpr-MPRA regulatory region 9358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152741433-152741972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152742168-152742668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152742669-152743169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152753877-152754691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152756808-152757380 Neighboring gene extracellular matrix protein X-linked, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30035 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30036 Neighboring gene ATPase plasma membrane Ca2+ transporting 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152809330-152810182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152825847-152826631 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152831014-152831626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21064 Neighboring gene cyclin Q

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables extracellular matrix binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables extracellular matrix structural constituent NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables extracellular matrix structural constituent conferring compression resistance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables extracellular matrix structural constituent conferring compression resistance RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables glycosaminoglycan binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in articular cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in bone development IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    biglycan
    Names
    bone/cartilage proteoglycan-I
    dermatan sulphate proteoglycan I
    small leucine-rich protein 1A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015961.1 RefSeqGene

      Range
      5028..19594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001711.6NP_001702.1  biglycan preproprotein

      See identical proteins and their annotated locations for NP_001702.1

      Status: REVIEWED

      Source sequence(s)
      AI538325, AK297966, BC002416, BQ180984, DC299956
      Consensus CDS
      CCDS14721.1
      UniProtKB/Swiss-Prot
      D3DWU3, P13247, P21810
      UniProtKB/TrEMBL
      A8K7E0, Q53FI4
      Related
      ENSP00000327336.4, ENST00000331595.9
      Conserved Domains (4) summary
      sd00031
      Location:302315
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:7191
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:277323
      LRR_8; Leucine rich repeat
      cl26018
      Location:64297
      NEL; C-terminal novel E3 ligase, LRR-interacting

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      153494980..153509546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029724.3XP_016885213.1  biglycan isoform X1

      UniProtKB/Swiss-Prot
      D3DWU3, P13247, P21810
      UniProtKB/TrEMBL
      A8K7E0, Q53FI4
      Conserved Domains (4) summary
      sd00031
      Location:302315
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:7191
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:277323
      LRR_8; Leucine rich repeat
      cl26018
      Location:64297
      NEL; C-terminal novel E3 ligase, LRR-interacting

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      151768553..151783109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327563.1XP_054183538.1  biglycan isoform X1

      UniProtKB/Swiss-Prot
      D3DWU3, P13247, P21810
      UniProtKB/TrEMBL
      A8K7E0, Q53FI4