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    RET ret proto-oncogene [ Homo sapiens (human) ]

    Gene ID: 5979, updated on 26-Feb-2024

    Summary

    Official Symbol
    RETprovided by HGNC
    Official Full Name
    ret proto-oncogeneprovided by HGNC
    Primary source
    HGNC:HGNC:9967
    See related
    Ensembl:ENSG00000165731 MIM:164761; AllianceGenome:HGNC:9967
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTC; MTC1; HSCR1; MEN2A; MEN2B; CDHF12; CDHR16; RET-ELE1
    Summary
    This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]
    Expression
    Biased expression in adrenal (RPKM 10.2), prostate (RPKM 1.3) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RET in Genome Data Viewer
    Location:
    10q11.21
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (43077069..43130351)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (43954542..44007848)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (43572517..43625799)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs2497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:43483113-43483758 Neighboring gene long intergenic non-protein coding RNA 1264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:43485513-43486245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:43492878-43493378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:43495973-43496668 Neighboring gene microRNA 5100 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:43507236-43508231 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:43508232-43509226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:43521134-43521642 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:43521643-43522150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:43522661-43523168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:43535603-43536323 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:43539799-43540690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:43540691-43541582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:43544190-43544720 Neighboring gene VISTA enhancer hs2498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:43557619-43558120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:43558121-43558620 Neighboring gene RET 5' regulatory region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:43572872-43573862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:43580156-43580656 Neighboring gene VISTA enhancer hs2326 Neighboring gene RET intron 1 enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:43596873-43597372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:43600219-43600970 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2313 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3282 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:43604510-43604673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3286 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:43625782-43626382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:43626383-43626983 Neighboring gene CSGALNACT2 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2318 Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:43655229-43656428 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_12290

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Professional guidelines

    Description
    Professional guideline
    ACMG 2013

    The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in RET that are pathogenic or expected to be pathogenic.

    GuidelinePubMed

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2020-08-26)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2020-08-26)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies potential susceptibility Loci for hirschsprung disease.
    EBI GWAS Catalog
    Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Peyer's patch morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in axon guidance TAS
    Traceable Author Statement
    more info
     
    involved_in cellular response to retinoic acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic epithelial tube formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in enteric nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glial cell-derived neurotrophic factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innervation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lymphocyte migration into lymphoid organs ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in membrane protein proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neural crest cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of metanephric glomerulus development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of neuron maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in posterior midgut development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retina development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ureter maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of plasma membrane protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    proto-oncogene tyrosine-protein kinase receptor Ret
    Names
    RET receptor tyrosine kinase
    cadherin family member 12
    cadherin-related family member 16
    proto-oncogene c-Ret
    rearranged during transfection
    ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
    NP_001342145.1
    NP_001393672.1
    NP_001393673.1
    NP_001393688.1
    NP_001393689.1
    NP_001393690.1
    NP_001393691.1
    NP_001393692.1
    NP_001393693.1
    NP_001393694.1
    NP_001393695.1
    NP_001393696.1
    NP_001393697.1
    NP_001393698.1
    NP_001393699.1
    NP_001393700.1
    NP_001393701.1
    NP_001393702.1
    NP_001393703.1
    NP_001393704.1
    NP_001393705.1
    NP_001393706.1
    NP_001393707.1
    NP_001393708.1
    NP_001393709.1
    NP_001393710.1
    NP_001393711.1
    NP_001393712.1
    NP_001393713.1
    NP_001393714.1
    NP_001393715.1
    NP_001393716.1
    NP_001393717.1
    NP_001393718.1
    NP_001393719.1
    NP_001393720.1
    NP_001393721.1
    NP_001393722.1
    NP_001393723.1
    NP_065681.1
    NP_066124.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007489.1 RefSeqGene

      Range
      5001..58283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_518

    mRNA and Protein(s)

    1. NM_001355216.2NP_001342145.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform d

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      B4DGX8
      Related
      ENST00000683007.1
      Conserved Domains (1) summary
      cd05045
      Location:469758
      PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
    2. NM_001406743.1NP_001393672.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/Swiss-Prot
      A8K6Z2, P07949, Q9BTB0
      UniProtKB/TrEMBL
      F8TLW0
    3. NM_001406744.1NP_001393673.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform b precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      F8TLW0
    4. NM_001406759.1NP_001393688.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform e precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      F8TLW0
    5. NM_001406760.1NP_001393689.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform e precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      F8TLW0
    6. NM_001406761.1NP_001393690.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform f precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      F8TLW0
    7. NM_001406762.1NP_001393691.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform f precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      F8TLW0
    8. NM_001406763.1NP_001393692.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform g precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      F8TLW0
    9. NM_001406764.1NP_001393693.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform h precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      F8TLW0
    10. NM_001406765.1NP_001393694.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform i precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      F8TLW0
    11. NM_001406766.1NP_001393695.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform j precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      F8TLW0
    12. NM_001406767.1NP_001393696.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform j precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      F8TLW0
    13. NM_001406768.1NP_001393697.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform k precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      F8TLW0
    14. NM_001406769.1NP_001393698.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform l precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      F8TLW0
    15. NM_001406770.1NP_001393699.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform m precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      F8TLW0
    16. NM_001406771.1NP_001393700.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform n precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      F8TLW0
    17. NM_001406772.1NP_001393701.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform o precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      A0A087WWB1, F8TLW0
      Related
      ENSP00000480088.2, ENST00000615310.5
    18. NM_001406773.1NP_001393702.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform p precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
      UniProtKB/TrEMBL
      F8TLW0
    19. NM_001406774.1NP_001393703.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform q precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    20. NM_001406775.1NP_001393704.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform r precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    21. NM_001406776.1NP_001393705.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform s precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    22. NM_001406777.1NP_001393706.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform t precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    23. NM_001406778.1NP_001393707.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform u precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    24. NM_001406779.1NP_001393708.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform v precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    25. NM_001406780.1NP_001393709.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform v precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    26. NM_001406781.1NP_001393710.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform w precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    27. NM_001406782.1NP_001393711.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform x precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    28. NM_001406783.1NP_001393712.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform y precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    29. NM_001406784.1NP_001393713.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform z precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    30. NM_001406785.1NP_001393714.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform aa precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    31. NM_001406786.1NP_001393715.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform bb precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    32. NM_001406787.1NP_001393716.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform cc precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    33. NM_001406788.1NP_001393717.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform dd precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    34. NM_001406789.1NP_001393718.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform dd precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    35. NM_001406790.1NP_001393719.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform ff precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    36. NM_001406791.1NP_001393720.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform gg precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    37. NM_001406792.1NP_001393721.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform hh precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    38. NM_001406793.1NP_001393722.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform ii precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    39. NM_001406794.1NP_001393723.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform jj precursor

      Status: REVIEWED

      Source sequence(s)
      AC010864
    40. NM_020630.7NP_065681.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform c precursor

      See identical proteins and their annotated locations for NP_065681.1

      Status: REVIEWED

      Source sequence(s)
      AC010864
      Consensus CDS
      CCDS53525.1
      UniProtKB/TrEMBL
      F8TLW0
      Related
      ENSP00000344798.4, ENST00000340058.6
      Conserved Domains (3) summary
      cd05045
      Location:7231012
      PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
      pfam00028
      Location:172261
      Cadherin; Cadherin domain
      pfam07714
      Location:7241005
      Pkinase_Tyr; Protein tyrosine kinase
    41. NM_020975.6NP_066124.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor

      See identical proteins and their annotated locations for NP_066124.1

      Status: REVIEWED

      Source sequence(s)
      AC010864, BC003072, BC004257, BM661773, X12949
      Consensus CDS
      CCDS7200.1
      UniProtKB/Swiss-Prot
      A8K6Z2, P07949, Q9BTB0
      UniProtKB/TrEMBL
      F8TLW0
      Related
      ENSP00000347942.3, ENST00000355710.8
      Conserved Domains (3) summary
      cd05045
      Location:7231012
      PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
      pfam00028
      Location:172261
      Cadherin; Cadherin domain
      pfam07714
      Location:7241005
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      43077069..43130351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      43954542..44007848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)