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Prkn parkin RBR E3 ubiquitin protein ligase [ Mus musculus (house mouse) ]

Gene ID: 50873, updated on 2-Nov-2024

Summary

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Official Symbol: Prknprovided by MGI
Official Full Name: parkin RBR E3 ubiquitin protein ligaseprovided by MGI
Primary source: MGI:MGI:1355296
See related: Ensembl:ENSMUSG00000023826 AllianceGenome:MGI:1355296
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Park2
Summary: Enables ubiquitin protein ligase activity. Involved in several processes, including negative regulation of intrinsic apoptotic signaling pathway; positive regulation of dendrite extension; and positive regulation of protein linear polyubiquitination. Acts upstream of or within several processes, including catecholamine metabolic process; chemical synaptic transmission; and startle response. Located in mitochondrion; neuron projection; and nucleus. Part of protein-containing complex. Is active in dopaminergic synapse. Is expressed in several structures, including face; nervous system; pancreas; sensory organ; and skeleton. Used to study Parkinson's disease 2. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; lung cancer; and ovarian cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in frontal lobe adult (RPKM 1.6), cortex adult (RPKM 1.5) and 19 other tissues See more
Orthologs: human all
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Genomic context

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See Prkn in Genome Data Viewer

Location:: 17 A1; 17 7.8 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (11059227..12282257)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (10840359..12063370)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of NLRP3 inflammasome ameliorates LPS-induced neuroinflammatory injury in mice via PINK1/Parkin pathway.
Title: Inhibition of NLRP3 inflammasome ameliorates LPS-induced neuroinflammatory injury in mice via PINK1/Parkin pathway.
Ubiquitin Ligase Parkin Regulates the Stability of SARS-CoV-2 Main Protease and Suppresses Viral Replication.
Title: Ubiquitin Ligase Parkin Regulates the Stability of SARS-CoV-2 Main Protease and Suppresses Viral Replication.
Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice.
Title: Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice.
PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia.
Title: PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia.
Blockade of Hepatocyte PCSK9 Ameliorates Hepatic Ischemia-Reperfusion Injury by Promoting Pink1-Parkin-Mediated Mitophagy.
Title: Blockade of Hepatocyte PCSK9 Ameliorates Hepatic Ischemia-Reperfusion Injury by Promoting Pink1-Parkin-Mediated Mitophagy.
Critical roles of parkin and PINK1 in coxsackievirus B3-induced viral myocarditis.
Title: Critical roles of parkin and PINK1 in coxsackievirus B3-induced viral myocarditis.
C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy.
Title: C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy.
Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent.
Title: Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent.
HYPERBILIRUBINEMIA AGGRAVATES RENAL ISCHEMIA REPERFUSION INJURY BY EXACERBATING PINK1-PARKIN-MEDIATED MITOPHAGY.
Title: HYPERBILIRUBINEMIA AGGRAVATES RENAL ISCHEMIA REPERFUSION INJURY BY EXACERBATING PINK1-PARKIN-MEDIATED MITOPHAGY.
Effects of Parkin on the Mitochondrial Genome in the Heart and Brain of Mitochondrial Mutator Mice.
Title: Effects of Parkin on the Mitochondrial Genome in the Heart and Brain of Mitochondrial Mutator Mice.

Submit: New GeneRIF Correction See all GeneRIFs (243)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Spontaneous (2) 1 citation
Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237570

NoName (e-PCR)
- UniSTS:237571

Park2 (e-PCR), detects polymorphism
- UniSTS:239146

D17Ertd648e (e-PCR), detects polymorphism
- UniSTS:167221

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Park2 (e-PCR), detects polymorphism
- UniSTS:527475

44.MMHAP58FRG11.seq (e-PCR)
- UniSTS:124541

NoName (e-PCR)
- UniSTS:225174

D17Jcs117 (e-PCR), detects polymorphism
- UniSTS:259233

D17Jcs70 (e-PCR), detects polymorphism
- UniSTS:259236

D17Jcs72 (e-PCR), detects polymorphism
- UniSTS:259237

D17Jcs75 (e-PCR), detects polymorphism
- UniSTS:259238

D17Mit113 (e-PCR), detects polymorphism
- UniSTS:127949

MHAa35a10.seq (e-PCR)
- UniSTS:125153

AB019558 (e-PCR)
- UniSTS:186085

Park2 (e-PCR), detects polymorphism
- UniSTS:507114

D17Mit156 (e-PCR), detects polymorphism
- UniSTS:127981

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables F-box domain binding	IEA Inferred from Electronic Annotation more info
enables F-box domain binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cullin family protein binding	IEA Inferred from Electronic Annotation more info
enables cullin family protein binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables phospholipase binding	IEA Inferred from Electronic Annotation more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-specific protease binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-specific protease binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aggresome assembly	IEA Inferred from Electronic Annotation more info
involved_in aggresome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagy of mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in autophagy of mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to L-glutamate	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen sulfide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to toxic substance	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to toxic substance	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dopamine uptake involved in synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in free ubiquitin chain polymerization	IEA Inferred from Electronic Annotation more info
involved_in free ubiquitin chain polymerization	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial fragmentation involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion localization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion to lysosome vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion to lysosome vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation by host of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in negative regulation by host of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of actin filament bundle assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of exosomal secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of exosomal secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glucokinase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of glucokinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intralumenal vesicle formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intralumenal vesicle formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of primary amine oxidase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of primary amine oxidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of spontaneous neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of spontaneous neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within norepinephrine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ATP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial fusion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitophagy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurotransmitter uptake	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neurotransmitter uptake	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein linear polyubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein linear polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type 2 mitophagy	ISO Inferred from Sequence Orthology more info
involved_in proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K11-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K11-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K48-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K6-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K6-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of dopamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of dopamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane potential	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle endocytosis	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation protein catabolic process at presynapse	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation protein catabolic process at presynapse	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation protein catabolic process at presynapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within startle response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptic transmission, dopaminergic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type 2 mitophagy	IEA Inferred from Electronic Annotation more info
involved_in type 2 mitophagy	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in aggresome	IEA Inferred from Electronic Annotation more info
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dopaminergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in dopaminergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in dopaminergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular vesicle	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion-derived vesicle	IEA Inferred from Electronic Annotation more info
colocalizes_with mitochondrion-derived vesicle	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase parkin

Names: Parkinson disease (autosomal recessive, juvenile) 2, parkin; parkin protein

NP_001304655.1

EC 2.3.2.31

NP_001390399.1

EC 2.3.2.31

NP_057903.1

EC 2.3.2.31

XP_006523400.1

EC 2.3.2.31

XP_006523402.1

EC 2.3.2.31

XP_017173061.1

EC 2.3.2.31

XP_017173062.1

EC 2.3.2.31

XP_017173065.1

EC 2.3.2.31

XP_030105754.1

EC 2.3.2.31

XP_036016575.1

EC 2.3.2.31

XP_036016576.1

EC 2.3.2.31

XP_036016577.1

EC 2.3.2.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001317726.2 → NP_001304655.1 E3 ubiquitin-protein ligase parkin isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) is shorter, and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC091254, AC091484, AC091777, AC093450, AC105305

UniProtKB/TrEMBL

A0A1W2P7W2

Related

ENSMUST00000186167.2

Conserved Domains (2) summary

cd01798
Location:3 → 72

parkin_N; amino-terminal ubiquitin-like of parkin protein

smart00213
Location:1 → 72

UBQ; Ubiquitin homologues
NM_001403470.1 → NP_001390399.1 E3 ubiquitin-protein ligase parkin isoform 3

Status: VALIDATED

Source sequence(s)

AC091254, AC091484, AC091777, AC093450, AC105305, AC122259, AC163687, CT009575
NM_016694.5 → NP_057903.1 E3 ubiquitin-protein ligase parkin isoform 1

See identical proteins and their annotated locations for NP_057903.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC091254, AC091484, AC091777, AC093450, AC105305, AC122259, AC163687, CT009575

Consensus CDS

CCDS79506.1

UniProtKB/Swiss-Prot

Q2KHJ9, Q9ES22, Q9ES23, Q9WVS6

Related

ENSMUSP00000140587.2, ENSMUST00000191124.7

Conserved Domains (4) summary

cd01798
Location:3 → 72

parkin_N; amino-terminal ubiquitin-like of parkin protein

smart00213
Location:1 → 72

UBQ; Ubiquitin homologues

smart00647
Location:313 → 374

IBR; In Between Ring fingers

pfam01485
Location:412 → 452

IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

11059227..12282257

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030249894.2 → XP_030105754.1 E3 ubiquitin-protein ligase parkin isoform X8

UniProtKB/TrEMBL

A0A1W2P7W2

Conserved Domains (3) summary

cd01798
Location:3 → 76

Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins

pfam17976
Location:144 → 216

zf-RING_12; RING/Ubox like zinc-binding domain

pfam17978
Location:227 → 244

zf-RING_14; RING/Ubox like zinc-binding domain
XM_036160683.1 → XP_036016576.1 E3 ubiquitin-protein ligase parkin isoform X7

Conserved Domains (2) summary

cd01798
Location:3 → 76

Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins

cd21382
Location:146 → 206

RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
XM_017317572.3 → XP_017173061.1 E3 ubiquitin-protein ligase parkin isoform X3

Conserved Domains (4) summary

smart00647
Location:314 → 375

IBR; In Between Ring fingers

cd01798
Location:3 → 76

Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins

pfam17976
Location:145 → 217

zf-RING_12; RING/Ubox like zinc-binding domain

pfam17978
Location:228 → 318

zf-RING_14; RING/Ubox like zinc-binding domain
XM_036160684.1 → XP_036016577.1 E3 ubiquitin-protein ligase parkin isoform X10

UniProtKB/TrEMBL

A0A1W2P7W2

Related

ENSMUSP00000156589.2, ENSMUST00000233294.2

Conserved Domains (3) summary

cd01798
Location:3 → 76

Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins

pfam17978
Location:228 → 246

zf-RING_14; RING/Ubox like zinc-binding domain

cd21382
Location:146 → 229

RING0_parkin; RING finger-like zinc-binding domain 0 of parkin
XM_017317576.3 → XP_017173065.1 E3 ubiquitin-protein ligase parkin isoform X9

UniProtKB/TrEMBL

B8YP90

Conserved Domains (2) summary

cd01798
Location:3 → 76

Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins

pfam17976
Location:145 → 206

zf-RING_12; RING/Ubox like zinc-binding domain
XM_006523339.4 → XP_006523402.1 E3 ubiquitin-protein ligase parkin isoform X6

UniProtKB/TrEMBL

A0A3B2W489

Related

ENSMUSP00000156810.2, ENSMUST00000233706.2

Conserved Domains (3) summary

pfam01485
Location:123 → 184

IBR; IBR domain, a half RING-finger domain

pfam17976
Location:1 → 26

zf-RING_12; RING/Ubox like zinc-binding domain

pfam17978
Location:37 → 127

zf-RING_14; RING/Ubox like zinc-binding domain
XM_036160682.1 → XP_036016575.1 E3 ubiquitin-protein ligase parkin isoform X2

Conserved Domains (5) summary

smart00647
Location:291 → 352

IBR; In Between Ring fingers

pfam01485
Location:390 → 430

IBR; IBR domain, a half RING-finger domain

pfam17978
Location:205 → 295

zf-RING_14; RING/Ubox like zinc-binding domain

cd21382
Location:123 → 206

RING0_parkin; RING finger-like zinc-binding domain 0 of parkin

cl28922
Location:34 → 53

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006523337.4 → XP_006523400.1 E3 ubiquitin-protein ligase parkin isoform X4

Conserved Domains (4) summary

smart00647
Location:183 → 244

IBR; In Between Ring fingers

pfam01485
Location:282 → 322

IBR; IBR domain, a half RING-finger domain

pfam17976
Location:14 → 86

zf-RING_12; RING/Ubox like zinc-binding domain

pfam17978
Location:97 → 187

zf-RING_14; RING/Ubox like zinc-binding domain
XM_017317573.2 → XP_017173062.1 E3 ubiquitin-protein ligase parkin isoform X5

Conserved Domains (4) summary

smart00647
Location:182 → 243

IBR; In Between Ring fingers

pfam01485
Location:281 → 321

IBR; IBR domain, a half RING-finger domain

pfam17976
Location:13 → 85

zf-RING_12; RING/Ubox like zinc-binding domain

pfam17978
Location:96 → 186

zf-RING_14; RING/Ubox like zinc-binding domain