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    AUD1 NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825458, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AUD1
    Official Full Name
    NAD(P)-binding Rossmann-fold superfamily protein
    Primary source
    TAIR:AT3G62830
    Locus tag
    AT3G62830
    See related
    Araport:AT3G62830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATUXS2; UDP-GLUCURONIC ACID DECARBOXYLASE 2; UXS2
    Summary
    encodes an isoform of UDP-glucuronic acid decarboxylase, which is predicted to be membrane-bound by PSORT. This enzyme produces UDP-xylose, which is a substrate for many cell wall carbohydrates including hemicellulose and pectin. UDP-xylose is also known to feedback regulate several cell wall biosynthetic enzymes.
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    Genomic context

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    See AUD1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (23232272..23235567)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene complex 1 family protein / LVR family protein Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene ncRNA Neighboring gene Small nuclear ribonucleoprotein family protein Neighboring gene zinc finger protein-like protein Neighboring gene alpha/beta-Hydrolases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular genetics of nucleotide sugar interconversion pathways in plants. Reiter WD, et al. Plant Mol Biol, 2001 Sep. PMID 11554483
    2. Biosynthesis of UDP-xylose: characterization of membrane-bound AtUxs2. Pattathil S, et al. Planta, 2005 Jun. PMID 15655675
    3. Biosynthesis of UDP-xylose. Cloning and characterization of a novel Arabidopsis gene family, UXS, encoding soluble and putative membrane-bound UDP-glucuronic acid decarboxylase isoforms. Harper AD, et al. Plant Physiol, 2002 Dec. PMID 12481102, Free PMC Article
    4. Role of UDP-Glucuronic Acid Decarboxylase in Xylan Biosynthesis in Arabidopsis. Kuang B, et al. Mol Plant, 2016 Aug 1. PMID 27179920
    5. Label-free protein quantification for plant Golgi protein localization and abundance. Nikolovski N, et al. Plant Physiol, 2014 Oct. PMID 25122472, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001125421.1
    NM_116148.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucuronate decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dTDP-glucose 4,6-dehydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-xylose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in D-xylose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-D-xylose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within dTDP-rhamnose biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi trans cisterna HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in endosome HDA PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in trans-Golgi network HDA PubMed 

    General protein information

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    Preferred Names
    NAD(P)-binding Rossmann-fold superfamily protein
    NP_001118893.1
    • UDP-GLUCURONIC ACID DECARBOXYLASE 2 (UXS2); FUNCTIONS IN: UDP-glucuronate decarboxylase activity, dTDP-glucose 4,6-dehydratase activity, catalytic activity; INVOLVED IN: dTDP-rhamnose biosynthetic process, nucleotide-sugar metabolic process, D-xylose metabolic process; LOCATED IN: plasma membrane, Golgi membrane, membrane; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: UDP-xylose synthase 4 (TAIR:AT2G47650.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_191842.1
    • AUD1; FUNCTIONS IN: UDP-glucuronate decarboxylase activity, dTDP-glucose 4,6-dehydratase activity, catalytic activity; INVOLVED IN: dTDP-rhamnose biosynthetic process, nucleotide-sugar metabolic process, D-xylose metabolic process; LOCATED IN: plasma membrane, Golgi membrane, membrane; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: UDP-xylose synthase 4 (TAIR:AT2G47650.1); Has 44607 Blast hits to 44567 proteins in 3006 species: Archae - 852; Bacteria - 26090; Metazoa - 741; Fungi - 328; Plants - 1343; Viruses - 47; Other Eukaryotes - 15206 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      23232272..23235567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116148.3 → NP_191842.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191842.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39077, Q9LZI2
      UniProtKB/TrEMBL
      A0A178VKB0, A0A5S9XNX2
      Conserved Domains (1) summary
      PLN02206
      Location:1 → 432
      PLN02206; UDP-glucuronate decarboxylase

    2. NM_001125421.1 → NP_001118893.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118893.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39077, Q9LZI2
      UniProtKB/TrEMBL
      A0A178VKB0, A0A5S9XNX2
      Conserved Domains (1) summary
      PLN02206
      Location:1 → 432
      PLN02206; UDP-glucuronate decarboxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LZI2.1

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