wars1 tryptophanyl-tRNA synthetase 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: wars1provided by Xenbase
Official Full Name: tryptophanyl-tRNA synthetase 1provided by Xenbase
Primary source: Xenbase:XB-GENE-954237
See related: Ensembl:ENSXETG00000002524 AllianceGenome:Xenbase:XB-GENE-954237
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: wars; ifi53; ifp53; gamma-2
Summary: Predicted to enable tryptophan-tRNA ligase activity. Predicted to be involved in tryptophanyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	8	NC_030684.2 (96622258..96637232, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	8	NC_030684.1 (75755919..75770928, complement)

Chromosome 8 - NC_030684.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables tryptophan-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tryptophan-tRNA ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
involved_in tryptophanyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tryptophanyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tryptophan--tRNA ligase, cytoplasmic

NP_001039220.1

EC 6.1.1.2

XP_012824021.1

EC 6.1.1.2

XP_012824022.1

EC 6.1.1.2

XP_017951785.1

EC 6.1.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045755.1 → NP_001039220.1 tryptophan--tRNA ligase, cytoplasmic

See identical proteins and their annotated locations for NP_001039220.1

Status: PROVISIONAL

Source sequence(s)

CR942634

UniProtKB/TrEMBL

F6VSS1, Q28BU4

Related

ENSXETP00000005375.4, ENSXETT00000005375.4

Conserved Domains (3) summary

PLN02486
Location:90 → 472

PLN02486; aminoacyl-tRNA ligase

TIGR00233
Location:160 → 475

trpS; tryptophanyl-tRNA synthetase

pfam00458
Location:17 → 69

WHEP-TRS; WHEP-TRS domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

96622258..96637232 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_012968568.2 → XP_012824022.1 tryptophan--tRNA ligase, cytoplasmic isoform X2

See identical proteins and their annotated locations for XP_012824022.1

UniProtKB/TrEMBL

F6VSS1, Q28BU4

Conserved Domains (3) summary

PLN02486
Location:90 → 472

PLN02486; aminoacyl-tRNA ligase

TIGR00233
Location:160 → 475

trpS; tryptophanyl-tRNA synthetase

pfam00458
Location:17 → 69

WHEP-TRS; WHEP-TRS domain
XM_018096296.2 → XP_017951785.1 tryptophan--tRNA ligase, cytoplasmic isoform X2

UniProtKB/TrEMBL

F6VSS1, Q28BU4
XM_012968567.3 → XP_012824021.1 tryptophan--tRNA ligase, cytoplasmic isoform X1

UniProtKB/TrEMBL

A0A6I8PPU5, F6VSS1

Related

ENSXETP00000059303.3, ENSXETT00000064879.3

Conserved Domains (2) summary

PLN02486
Location:132 → 514

PLN02486; aminoacyl-tRNA ligase

cd00936
Location:59 → 108

WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...