Gcm1 glial cells missing homolog 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gcm1provided by MGI
Official Full Name: glial cells missing homolog 1provided by MGI
Primary source: MGI:MGI:108045
See related: Ensembl:ENSMUSG00000023333 AllianceGenome:MGI:108045
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GCMa; glide; Gcm-rs2; Gcm1-rs1
Summary: Enables DNA binding activity and zinc ion binding activity. Acts upstream of or within several processes, including astrocyte fate commitment; embryonic placenta development; and positive regulation of syncytium formation by plasma membrane fusion. Located in nucleus. Is expressed in several structures, including extraembryonic component; limb; metanephros; placenta; and thymus. Orthologous to human GCM1 (glial cells missing transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in placenta adult (RPKM 1.9) and kidney adult (RPKM 1.2) See more
Orthologs: human all
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Genomic context

Location:: 9 E1; 9 43.49 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (77959240..77972906)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (78051958..78065624)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aberrant Gcm1 expression mediates Wnt/beta-catenin pathway activation in folate deficiency involved in neural tube defects.
Title: Aberrant Gcm1 expression mediates Wnt/β-catenin pathway activation in folate deficiency involved in neural tube defects.
Gcm1 is involved in cell proliferation and fibrosis during kidney regeneration after ischemia-reperfusion injury.
Title: Gcm1 is involved in cell proliferation and fibrosis during kidney regeneration after ischemia-reperfusion injury.
GCM1-directed villous trophoblast differentiation is repressed by DREAM
Title: DREAM mediated regulation of GCM1 in the human placental trophoblast.
Data show that the GCM1/syncytin-B pathway is significantly downregulated in the placenta of BCL9L-deficient mice and that the fusion and differentiation of ST-II cells are blocked.
Title: Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway.
as in mice, fetoplacental vascularity increased when GCM1 protein expression decreased (R(2)=-0.45; P<0.05).
Title: Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice.
Gcm1 (glial cells missing 1) are involved in the epigenetic regulation of Hes5 transcription by DNA demethylation independently of DNA replication.
Title: Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells.
studies identify a novel function of p45NF-E2 during placental development: in trophoblast cells, p45NF-E2 represses Gcm1 and syncytiotrophoblast formation via acetylation
Title: p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium formation, placental vascularization and embryonic growth.
Gcm1 is co-expressed with Cebpa and Synb in basal cells in contact with the allantois.
Title: Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth.
Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1
Title: Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1.
mGCMa expression is primarily postnatal, arguing for a role in organ function rather than organ development
Title: Restricted expression of mouse GCMa/Gcm1 in kidney and thymus.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

General gene information

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Markers

Gcm1 (e-PCR), detects polymorphism
- UniSTS:547907

Gcm1 (e-PCR), detects polymorphism
- UniSTS:547725

Gcm1 (e-PCR), detects polymorphism
- UniSTS:547726

D88612 (e-PCR)
- UniSTS:179940

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISA Inferred from Sequence Alignment more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within astrocyte fate commitment	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation involved in embryonic placenta development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation involved in embryonic placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gliogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of syncytium formation by plasma membrane fusion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell differentiation involved in embryonic placenta development	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell differentiation involved in embryonic placenta development	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of syncytium formation by plasma membrane fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chorion-specific transcription factor GCMa

Names: GCM motif protein 1; Gcm 1; Gcm a; glial cell deficient; mGCM1; mGCMa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.