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    ARHGAP22 Rho GTPase activating protein 22 [ Phascolarctos cinereus (koala) ]

    Gene ID: 110215515, updated on 15-Mar-2024

    Summary

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    Gene symbol
    ARHGAP22
    Gene description
    Rho GTPase activating protein 22
    See related
    Ensembl:ENSPCIG00000027048
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Phascolarctos cinereus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Diprotodontia; Phascolarctidae; Phascolarctos
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGAP22 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    100 current phaCin_unsw_v4.1 (GCF_002099425.1) Unplaced Scaffold NW_018344017.1 (5459987..5872385, complement)

    NW_018344017.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene FERM and PDZ domain containing 2 Neighboring gene uncharacterized LOC110215517 Neighboring gene mitogen-activated protein kinase 8 Neighboring gene transfer RNA asparagine (anticodon GUU) Neighboring gene WDFY family member 4 Neighboring gene leucine rich repeat containing 18

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_018344017 Unplaced Scaffold Reference phaCin_unsw_v4.1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho GTPase-activating protein 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Phascolarctos cinereus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference phaCin_unsw_v4.1 Primary Assembly

    Genomic

    1. NW_018344017.1 Reference phaCin_unsw_v4.1 Primary Assembly

      Range
      5459987..5872385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_020997088.1 → XP_020852747.1  rho GTPase-activating protein 22 isoform X1

      UniProtKB/TrEMBL
      A0A6P5L4Q2
      Conserved Domains (4) summary
      cd04390
      Location:173 → 371
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      cd13378
      Location:42 → 157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam09726
      Location:532 → 727
      Macoilin; Transmembrane protein
      cl25732
      Location:647 → 726
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_020997091.1 → XP_020852750.1  rho GTPase-activating protein 22 isoform X3

      UniProtKB/TrEMBL
      A0A6P5L332
      Related
      ENSPCIP00000036666.2, ENSPCIT00000045129.2
      Conserved Domains (4) summary
      cd04390
      Location:157 → 355
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      cd13378
      Location:42 → 157
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam09726
      Location:516 → 711
      Macoilin; Transmembrane protein
      cl25732
      Location:631 → 710
      SMC_N; RecF/RecN/SMC N terminal domain

    3. XM_020997089.1 → XP_020852748.1  rho GTPase-activating protein 22 isoform X2

      UniProtKB/TrEMBL
      A0A6P5L3U1
      Related
      ENSPCIP00000036668.2, ENSPCIT00000045131.2
      Conserved Domains (4) summary
      cd04390
      Location:167 → 365
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      cd13378
      Location:36 → 151
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam09726
      Location:526 → 721
      Macoilin; Transmembrane protein
      cl25732
      Location:641 → 720
      SMC_N; RecF/RecN/SMC N terminal domain

    4. XM_020997093.1 → XP_020852752.1  rho GTPase-activating protein 22 isoform X4

      UniProtKB/TrEMBL
      A0A6P5LAS1
      Related
      ENSPCIP00000036664.2, ENSPCIT00000045127.2
      Conserved Domains (4) summary
      cd04390
      Location:149 → 347
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      cd13378
      Location:18 → 133
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam09726
      Location:508 → 703
      Macoilin; Transmembrane protein
      cl25732
      Location:623 → 702
      SMC_N; RecF/RecN/SMC N terminal domain

    5. XM_020997092.1 → XP_020852751.1  rho GTPase-activating protein 22 isoform X4

      UniProtKB/TrEMBL
      A0A6P5LAS1
      Conserved Domains (4) summary
      cd04390
      Location:149 → 347
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      cd13378
      Location:18 → 133
      PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
      pfam09726
      Location:508 → 703
      Macoilin; Transmembrane protein
      cl25732
      Location:623 → 702
      SMC_N; RecF/RecN/SMC N terminal domain

    6. XM_020997096.1 → XP_020852755.1  rho GTPase-activating protein 22 isoform X7

      UniProtKB/TrEMBL
      A0A6P5L337
      Conserved Domains (4) summary
      cd04390
      Location:77 → 275
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam09726
      Location:436 → 631
      Macoilin; Transmembrane protein
      cl17171
      Location:12 → 61
      PH-like; Pleckstrin homology-like domain
      cl25732
      Location:551 → 630
      SMC_N; RecF/RecN/SMC N terminal domain

    7. XM_020997098.1 → XP_020852757.1  rho GTPase-activating protein 22 isoform X9

      UniProtKB/TrEMBL
      A0A6P5L4R4
      Conserved Domains (4) summary
      cd04390
      Location:52 → 250
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam09726
      Location:411 → 606
      Macoilin; Transmembrane protein
      cl17171
      Location:1 → 36
      PH-like; Pleckstrin homology-like domain
      cl25732
      Location:526 → 605
      SMC_N; RecF/RecN/SMC N terminal domain

    8. XM_020997095.1 → XP_020852754.1  rho GTPase-activating protein 22 isoform X6

      UniProtKB/TrEMBL
      A0A6P5L7N3
      Conserved Domains (4) summary
      cd04390
      Location:77 → 275
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam09726
      Location:436 → 631
      Macoilin; Transmembrane protein
      cl17171
      Location:18 → 61
      PH-like; Pleckstrin homology-like domain
      cl25732
      Location:551 → 630
      SMC_N; RecF/RecN/SMC N terminal domain

    9. XM_020997097.1 → XP_020852756.1  rho GTPase-activating protein 22 isoform X8

      UniProtKB/TrEMBL
      A0A6P5LAS6
      Conserved Domains (4) summary
      cd04390
      Location:66 → 264
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam09726
      Location:425 → 620
      Macoilin; Transmembrane protein
      cl17171
      Location:7 → 50
      PH-like; Pleckstrin homology-like domain
      cl25732
      Location:540 → 619
      SMC_N; RecF/RecN/SMC N terminal domain

    10. XM_020997094.1 → XP_020852753.1  rho GTPase-activating protein 22 isoform X5

      UniProtKB/TrEMBL
      A0A6P5L3U4
      Conserved Domains (3) summary
      cd04390
      Location:82 → 280
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam09726
      Location:441 → 636
      Macoilin; Transmembrane protein
      cl25732
      Location:556 → 635
      SMC_N; RecF/RecN/SMC N terminal domain
    Nucleotide Protein
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