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    Pbk PDZ binding kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290326, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Pbkprovided by RGD
    Official Full Name
    PDZ binding kinaseprovided by RGD
    Primary source
    RGD:1309565
    See related
    EnsemblRapid:ENSRNOG00000015308 AllianceGenome:RGD:1309565
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in stress-activated MAPK cascade. Predicted to act upstream of or within several processes, including cellular response to UV; negative regulation of protein metabolic process; and negative regulation of stress-activated MAPK cascade. Predicted to be located in nucleus. Orthologous to human PBK (PDZ binding kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 96.0), Thymus (RPKM 81.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pbk in Genome Data Viewer
    Location:
    15p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (44198506..44209572)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (40022873..40034014)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (42489253..42500377)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097185 Neighboring gene scavenger receptor class A, member 5 Neighboring gene uncharacterized LOC108352941 Neighboring gene uncharacterized LOC134482136 Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene coiled-coil domain containing 25 Neighboring gene NOP53 ribosome biogenesis factor, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Activation of T-LAK-cell-originated protein kinase-mediated antioxidation protects against focal cerebral ischemia-reperfusion injury. Zhao H, et al. FEBS J, 2014 Oct. PMID 25065601
    2. Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins. Rizkallah R, et al. Oncotarget, 2015 Jan 30. PMID 25575812, Free PMC Article
    3. T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway. Li S, et al. J Biol Chem, 2011 Aug 26. PMID 21715333, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TOPK confers neuroprotection against focal cerebral ischemia-reperfusion injury by antioxidative function.
      Title: Activation of T-LAK-cell-originated protein kinase-mediated antioxidation protects against focal cerebral ischemia-reperfusion injury.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress-activated MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lymphokine-activated killer T-cell-originated protein kinase
    NP_001073406.1
    XP_006252165.1
    XP_006252167.1
    XP_006252168.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079937.1 → NP_001073406.1  lymphokine-activated killer T-cell-originated protein kinase

      See identical proteins and their annotated locations for NP_001073406.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129099
      UniProtKB/TrEMBL
      A1L1J7, D4A9B1
      Conserved Domains (1) summary
      cd14001
      Location:32 → 319
      PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      44198506..44209572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252103.5 → XP_006252165.1  lymphokine-activated killer T-cell-originated protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006252165.1

      UniProtKB/TrEMBL
      A1L1J7, D4A9B1
      Related
      ENSRNOP00000100563.1, ENSRNOT00000132475.1
      Conserved Domains (1) summary
      cd14001
      Location:32 → 319
      PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase

    2. XM_006252106.5 → XP_006252168.1  lymphokine-activated killer T-cell-originated protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006252168.1

      UniProtKB/TrEMBL
      A1L1J7, D4A9B1
      Related
      ENSRNOP00000061382.2, ENSRNOT00000064306.5
      Conserved Domains (1) summary
      cd14001
      Location:32 → 319
      PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase

    3. XM_006252105.3 → XP_006252167.1  lymphokine-activated killer T-cell-originated protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006252167.1

      UniProtKB/TrEMBL
      A1L1J7, D4A9B1
      Conserved Domains (1) summary
      cd14001
      Location:32 → 319
      PKc_TOPK; Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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