Cpne6 copine 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cpne6provided by RGD
Official Full Name: copine 6provided by RGD
Primary source: RGD:1583895
See related: EnsemblRapid:ENSRNOG00000018399 AllianceGenome:RGD:1583895
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium-dependent phospholipid binding activity and phosphatidylserine binding activity. Predicted to be involved in cellular response to calcium ion; positive regulation of dendrite extension; and postsynaptic actin cytoskeleton organization. Predicted to be located in several cellular components, including axon; clathrin-coated endocytic vesicle; and dendrite. Predicted to be active in plasma membrane. Orthologous to human CPNE6 (copine 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 138.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (32968047..32975008)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (28998293..29005044)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (34187229..34194107)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we identify copine-6 as a specific regulator of spontaneous neurotransmission
Title: Copine-6 Binds to SNAREs and Selectively Suppresses Spontaneous Neurotransmission.
This study demonstrated that the copine-6 regulates BDNF-dependent changes in dendritic spine morphology to promote synaptic plasticity.
Title: Regulation of Dendritic Spine Morphology in Hippocampal Neurons by Copine-6.
Results provide the first evidence that impaired learning and memory in non-alcoholic fatty liver disease rats was, at least partly, associated with increased plasma nesfatin-1 concentration and decreased copine 6 expression in the hippocampus and prefrontal cortex.
Title: Impaired learning and memory in rats induced by a high-fat diet: Involvement with the imbalance of nesfatin-1 abundance and copine 6 expression.
expression of CPNE6 increased remarkably in brains of epileptic patients and in experimental epileptic rats. Expression is mainly in neurons.
Title: Increased expression of copine VI in patients with refractory epilepsy and a rat model.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to calcium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: copine-6

Names: copine VI (neuronal)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191113.2 → NP_001178042.2 copine-6

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A6KH05, D4ACG7, H1UBM5

Related

ENSRNOP00000024978.5, ENSRNOT00000024978.8

Conserved Domains (3) summary

cd04047
Location:152 → 266

C2B_Copine; C2 domain second repeat in Copine

cd04048
Location:20 → 137

C2A_Copine; C2 domain first repeat in Copine

pfam07002
Location:325 → 541

Copine