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    PF3D7_1324900 L-lactate dehydrogenase [ Plasmodium falciparum 3D7 ]

    Gene ID: 814112, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1324900
    Gene description
    L-lactate dehydrogenase
    Locus tag
    PF3D7_1324900
    See related
    PlasmoDB:PF3D7_1324900; VEuPathDB:PF3D7_1324900
    Gene type
    protein coding
    RNA name
    L-lactate dehydrogenase
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1324900 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    1
    Sequence:
    Chromosome: 13; NC_004331.3 (1041157..1042107)

    Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene SNARE protein, putative Neighboring gene dihydrofolate synthase/folylpolyglutamate synthase Neighboring gene U6 snRNA-associated Sm-like protein LSm6, putative Neighboring gene phosphoribosylpyrophosphate synthetase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004331.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro. Correa R, et al. Sci Rep, 2019 Mar 25. PMID 30911042, Free PMC Article
    2. Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase by a DNA aptamer. Cheung YW, et al. Proc Natl Acad Sci U S A, 2013 Oct 1. PMID 24043813, Free PMC Article
    3. HRP2 and pLDH-Based Rapid Diagnostic Tests, Expert Microscopy, and PCR for Detection of Malaria Infection during Pregnancy and at Delivery in Areas of Varied Transmission: A Prospective Cohort Study in Burkina Faso and Uganda. Kyabayinze DJ, et al. PLoS One, 2016. PMID 27380525, Free PMC Article
    4. The interactome of 2-Cys peroxiredoxins in Plasmodium falciparum. Brandstaedter C, et al. Sci Rep, 2019 Sep 19. PMID 31537845, Free PMC Article
    5. A secretory multifunctional serine protease, DegP of Plasmodium falciparum, plays an important role in thermo-oxidative stress, parasite growth and development. Sharma S, et al. FEBS J, 2014 Mar. PMID 24494818

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro.
      Title: Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro.
    2. Data suggest that HRP2/pan pLDH rapid diagnostic tests (RDTs), with specificity greater than 96%, are the most appropriate point-of-care test currently available for use during pregnancy especially for symptomatic women.
      Title: HRP2 and pLDH-Based Rapid Diagnostic Tests, Expert Microscopy, and PCR for Detection of Malaria Infection during Pregnancy and at Delivery in Areas of Varied Transmission: A Prospective Cohort Study in Burkina Faso and Uganda.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in extracellular vesicle HDA PubMed 
    located_in extracellular vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in food vacuole HDA PubMed 
    located_in intracellular anatomical structure ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in mitochondrion RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    L-lactate dehydrogenase
    XP_001349989.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004331.3 Reference assembly

      Range
      1041157..1042107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001349953.1 → XP_001349989.1  L-lactate dehydrogenase [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001349989.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q27743
      UniProtKB/TrEMBL
      A0A024V3C8, A0A024VEG1, A0A024W2N3, A0A024WJS8, A0A024X283, A0A0L1I581, A0A0L7K810, A0A0L7LZH7, A0A2S0BC21, A0A2S0BC37, A0A2S0BC44, A0A2S0BF37, A0A2S0D660, A0A4Y5WWV5, Q71T02, Q76NM3, W4IC99, W4IX97, W7EW58, W7FQH8, W7J807, W7KAW6
      Conserved Domains (1) summary
      PTZ00082
      Location:1 → 316
      PTZ00082; L-lactate dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    3ZH2_A.1
    3ZH2_B.1
    3ZH2_C.1
    3ZH2_D.1

    Gene LinkOut

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