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    PF3D7_1458000 cysteine proteinase falcipain 1 [ Plasmodium falciparum 3D7 ]

    Gene ID: 812135, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1458000
    Gene description
    cysteine proteinase falcipain 1
    Locus tag
    PF3D7_1458000
    See related
    PlasmoDB:PF3D7_1458000; VEuPathDB:PF3D7_1458000
    Gene type
    protein coding
    RNA name
    cysteine proteinase falcipain 1
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1458000 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    1
    Sequence:
    Chromosome: 14; NC_037283.1 (2387786..2389495)

    Chromosome 14 - NC_037283.1Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene protein PET117, putative Neighboring gene conserved Plasmodium protein, unknown function

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037283.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for the protease falcipain 1 in host cell invasion by the human malaria parasite. Greenbaum DC, et al. Science, 2002 Dec 6. PMID 12471262
    2. Isolation and characterization of a cysteine proteinase gene of Plasmodium falciparum. Rosenthal PJ, et al. Mol Biochem Parasitol, 1992 Mar. PMID 1565129
    3. Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368868
    4. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables cysteine-type peptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within hemoglobin catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within symbiont entry into host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine proteinase falcipain 1
    XP_001348727.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037283.1 Reference assembly

      Range
      2387786..2389495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001348691.1 → XP_001348727.1  cysteine proteinase falcipain 1 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001348727.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P25805, Q8I6V0
      UniProtKB/TrEMBL
      A0A024UZ62, A0A024VJU9, A0A024VZF4, A0A024WIK2, A0A024X051, W4I971, W4IY11, W7F3X0, W7FQF5, W7J3Y7, W7JZY7
      Conserved Domains (2) summary
      smart00848
      Location:225 → 282
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:333 → 568
      Peptidase_C1; Papain family cysteine protease
    Nucleotide Protein
    Heading Accession and Version

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