Rabif RAB interacting factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rabifprovided by RGD
Full Name: RAB interacting factorprovided by RGD
Primary source: RGD:1359331
See related: EnsemblRapid:ENSRNOG00000004424 AllianceGenome:RGD:1359331
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mss4; RGD1563962
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and zinc ion binding activity. Predicted to be involved in post-Golgi vesicle-mediated transport. Predicted to be active in cytosol and membrane. Orthologous to human RABIF (RAB interacting factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 89.3), Brain (RPKM 87.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (48488370..48500853)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (45936371..45948929)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (51317476..51330536)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Female-biased transcript levels when controlled by BDIV resistance alleles at Mss4.
Title: Genetic dissection of the Mss4 locus mediating sex-biased cancer resistance in the rat peripheral nervous system.
Transcription profiling using trigeminal nerve tissue of BDIX, BDIV, and BDIX.BDIV-Mss4a congenics of both sexes revealed 61 genes located in the Mss4a fragment differentially expressed between BDIV and BDIX rats.
Title: Sex-biased suppression of chemically induced neural carcinogenesis in congenic BDIX.BDIV-Mss4a rats.
MSS4 modulates Rab15 activity in early endocytosis (also called RABIF).
Title: Mammalian suppressor of Sec4 modulates the inhibitory effect of Rab15 during early endocytosis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139414 (e-PCR)
- UniSTS:221500

AU046955 (e-PCR)
- UniSTS:110982

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in post-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanine nucleotide exchange factor MSS4

Names: guanine-nucleotide-releasing protein mss4; mammalian suppressor of Sec4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007678.2 → NP_001007679.1 guanine nucleotide exchange factor MSS4

See identical proteins and their annotated locations for NP_001007679.1

Status: VALIDATED

Source sequence(s)

BM388378, CF977877, CO393618, DY319223

UniProtKB/Swiss-Prot

Q08326

UniProtKB/TrEMBL

B1WBM2

Related

ENSRNOP00000005845.3, ENSRNOT00000005845.8

Conserved Domains (1) summary

cd00246
Location:19 → 123

RabGEF; Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type; RabGEF positely regulates the function of Rab GTPase by promoting exchange of GDP for GTP; members of the Rab subfamily of Ras GTPases are important in vesicular transport;